Astaxanthin Exerts Immunomodulatory Effect by Regulating SDH-HIF-1α Axis and Reprogramming Mitochondrial Metabolism in LPS-Stimulated RAW264.7 Cells

Astaxanthin Exerts Immunomodulatory Effect by Regulating SDH-HIF-1α Axis and Reprogramming Mitochondrial Metabolism in LPS-Stimulated RAW264.7 Cells

Astaxanthin (AX) is a carotenoid that exerts potent antioxidant activity and acts in cell membranes and mitochondria, which consist of the bilayer molecules. Targeting mitochondria to ameliorate inflammatory diseases by regulating mitochondrial metabolism has become possible and topical. Although AX...

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Bibliographic Details
Main Authors: Luchuanyang Sun, Sangeun Kim, Ryoichi Mori, Nobuyuki Miyaji, Takeshi Nikawa, Katsuya Hirasaka
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Marine Drugs
Subjects:
astaxanthin
mitochondrial ROS
mitochondrial energy metabolism
mitochondrial succinate dehydrogenase
hypoxia-inducible factor-1α
interleukin-1β
Online Access:https://www.mdpi.com/1660-3397/20/11/660

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