Structural and Biophysical Characterization of Stable Alpha-Synuclein Oligomers

Structural and Biophysical Characterization of Stable Alpha-Synuclein Oligomers

The aggregation of α-synuclein (α-syn) into neurotoxic oligomers and fibrils is an important pathogenic feature of synucleinopatheis, including Parkinson’s disease (PD). A further characteristic of PD is the oxidative stress that results in the formation of aldehydes by lipid peroxidation. It has be...

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Bibliographic Details
Main Authors: Nishant Vaikath, Indulekha Sudhakaran, Ilham Abdi, Vijay Gupta, Nour Majbour, Simona Ghanem, Houari Abdesselem, Kostas Vekrellis, Omar El-Agnaf
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
alpha-synuclein
oligomers
HNE
ONE
DA
Parkinson’s disease
Online Access:https://www.mdpi.com/1422-0067/23/23/14630

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