SOX2 promoter hypermethylation in non-smoking Taiwanese adults residing in air pollution areas
Abstract Background Both SOX2 promoter methylation and air pollution have been associated with lung cancer risk. However, little has been done to assess SOX2 promoter methylation in individuals living in air pollution areas. The aim of this study was to investigate SOX2 promoter methylation in non-s...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-03-01
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| Series: | Clinical Epigenetics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13148-019-0647-8 |
| _version_ | 1829510640775987200 |
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| author | Disline Manli Tantoh Ming-Fang Wu Chien-Chang Ho Chia-Chi Lung Kuan-Jung Lee Oswald Ndi Nfor Yi-Chia Liaw Shu-Yi Hsu Pei-Hsin Chen Chin Lin Hou-Wei Chu Yi-Ching Liaw Yung-Po Liaw |
| author_facet | Disline Manli Tantoh Ming-Fang Wu Chien-Chang Ho Chia-Chi Lung Kuan-Jung Lee Oswald Ndi Nfor Yi-Chia Liaw Shu-Yi Hsu Pei-Hsin Chen Chin Lin Hou-Wei Chu Yi-Ching Liaw Yung-Po Liaw |
| author_sort | Disline Manli Tantoh |
| collection | DOAJ |
| description | Abstract Background Both SOX2 promoter methylation and air pollution have been associated with lung cancer risk. However, little has been done to assess SOX2 promoter methylation in individuals living in air pollution areas. The aim of this study was to investigate SOX2 promoter methylation in non-smoking Taiwanese adults living in areas with different levels of air pollution especially particulate matter with diameter < 2.5 μm (PM2.5). Methods A total of 1142 individuals aged 30–70 years were recruited. Data on SOX2 methylation, residence, age, and exposure to second-hand smoke (SHS) among others were extracted from the Taiwan Biobank dataset (2008–2015). After excluding former and current smokers, alongside those with incomplete information, a total of 461 non-smokers comprising 176 men and 285 women were included in the study. Participants’ residences were grouped under northern and central/southern areas because air pollution (PM2.5) is lower in northern compared to central and southern areas. Results The methylation levels in men (0.16310 ± 0.01230) and women (0.15740 ± 0.01240) were significantly different (P < .0001). In both sexes, the SOX2 promoter region was shown to be significantly hypermethylated in central and southern areas compared with the northern areas. The regression coefficient (β) was 0.00331 (P = 0.0257) in men and 0.00514 (P < .0001) in women. Conclusion SOX2 was significantly hypermethylated in both men and women residing in central and southern areas. The consistency in the results for both sexes shows that SOX2 promoter methylation could serve as a potential biomarker for industrial air pollution exposure. Moreover, it might reflect predisposition to cancer. Hence, healthy non-smokers at precancerous stages who have not been clinically diagnosed could be identified. |
| first_indexed | 2024-12-16T12:07:54Z |
| format | Article |
| id | doaj.art-705935dbfb3642e1b7f6618af9aed892 |
| institution | Directory Open Access Journal |
| issn | 1868-7075 1868-7083 |
| language | English |
| last_indexed | 2024-12-16T12:07:54Z |
| publishDate | 2019-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical Epigenetics |
| spelling | doaj.art-705935dbfb3642e1b7f6618af9aed8922022-12-21T22:32:16ZengBMCClinical Epigenetics1868-70751868-70832019-03-011111710.1186/s13148-019-0647-8SOX2 promoter hypermethylation in non-smoking Taiwanese adults residing in air pollution areasDisline Manli Tantoh0Ming-Fang Wu1Chien-Chang Ho2Chia-Chi Lung3Kuan-Jung Lee4Oswald Ndi Nfor5Yi-Chia Liaw6Shu-Yi Hsu7Pei-Hsin Chen8Chin Lin9Hou-Wei Chu10Yi-Ching Liaw11Yung-Po Liaw12Department of Public Health and Institute of Public Health, Chung Shan Medical UniversityDepartment of Public Health and Institute of Public Health, Chung Shan Medical UniversityDepartment of Physical Education, Fu-Jen Catholic UniversityDepartment of Public Health and Institute of Public Health, Chung Shan Medical UniversityDepartment of Public Health and Institute of Public Health, Chung Shan Medical UniversityDepartment of Public Health and Institute of Public Health, Chung Shan Medical UniversityDepartment of Medical Education, Taipei Veterans General HospitalDepartment of Public Health and Institute of Public Health, Chung Shan Medical UniversityDepartment of Public Health and Institute of Public Health, Chung Shan Medical UniversityGraduate Institute of Life Sciences, National Defense Medical CenterInstitute of Biomedical Sciences, Academia SinicaInstitute of Clinical Medicine, National Yang-Ming UniversityDepartment of Public Health and Institute of Public Health, Chung Shan Medical UniversityAbstract Background Both SOX2 promoter methylation and air pollution have been associated with lung cancer risk. However, little has been done to assess SOX2 promoter methylation in individuals living in air pollution areas. The aim of this study was to investigate SOX2 promoter methylation in non-smoking Taiwanese adults living in areas with different levels of air pollution especially particulate matter with diameter < 2.5 μm (PM2.5). Methods A total of 1142 individuals aged 30–70 years were recruited. Data on SOX2 methylation, residence, age, and exposure to second-hand smoke (SHS) among others were extracted from the Taiwan Biobank dataset (2008–2015). After excluding former and current smokers, alongside those with incomplete information, a total of 461 non-smokers comprising 176 men and 285 women were included in the study. Participants’ residences were grouped under northern and central/southern areas because air pollution (PM2.5) is lower in northern compared to central and southern areas. Results The methylation levels in men (0.16310 ± 0.01230) and women (0.15740 ± 0.01240) were significantly different (P < .0001). In both sexes, the SOX2 promoter region was shown to be significantly hypermethylated in central and southern areas compared with the northern areas. The regression coefficient (β) was 0.00331 (P = 0.0257) in men and 0.00514 (P < .0001) in women. Conclusion SOX2 was significantly hypermethylated in both men and women residing in central and southern areas. The consistency in the results for both sexes shows that SOX2 promoter methylation could serve as a potential biomarker for industrial air pollution exposure. Moreover, it might reflect predisposition to cancer. Hence, healthy non-smokers at precancerous stages who have not been clinically diagnosed could be identified.http://link.springer.com/article/10.1186/s13148-019-0647-8SOX2HypermethylationNon-smokingAir pollutionBiomarkerTaiwan Biobank |
| spellingShingle | Disline Manli Tantoh Ming-Fang Wu Chien-Chang Ho Chia-Chi Lung Kuan-Jung Lee Oswald Ndi Nfor Yi-Chia Liaw Shu-Yi Hsu Pei-Hsin Chen Chin Lin Hou-Wei Chu Yi-Ching Liaw Yung-Po Liaw SOX2 promoter hypermethylation in non-smoking Taiwanese adults residing in air pollution areas Clinical Epigenetics SOX2 Hypermethylation Non-smoking Air pollution Biomarker Taiwan Biobank |
| title | SOX2 promoter hypermethylation in non-smoking Taiwanese adults residing in air pollution areas |
| title_full | SOX2 promoter hypermethylation in non-smoking Taiwanese adults residing in air pollution areas |
| title_fullStr | SOX2 promoter hypermethylation in non-smoking Taiwanese adults residing in air pollution areas |
| title_full_unstemmed | SOX2 promoter hypermethylation in non-smoking Taiwanese adults residing in air pollution areas |
| title_short | SOX2 promoter hypermethylation in non-smoking Taiwanese adults residing in air pollution areas |
| title_sort | sox2 promoter hypermethylation in non smoking taiwanese adults residing in air pollution areas |
| topic | SOX2 Hypermethylation Non-smoking Air pollution Biomarker Taiwan Biobank |
| url | http://link.springer.com/article/10.1186/s13148-019-0647-8 |
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