Neurotrophin signalling in the human nervous system
This review focuses on neurotrophins and their tyrosine kinase receptors, with an emphasis on their relevance to the function and dysfunction in the human nervous system. It also deals with measurements of BDNF levels and highlights recent findings from our laboratory on TrkB and TrkC signalling in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1225373/full |
| _version_ | 1797787818629529600 |
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| author | Sarah Ateaque Spyros Merkouris Yves-Alain Barde |
| author_facet | Sarah Ateaque Spyros Merkouris Yves-Alain Barde |
| author_sort | Sarah Ateaque |
| collection | DOAJ |
| description | This review focuses on neurotrophins and their tyrosine kinase receptors, with an emphasis on their relevance to the function and dysfunction in the human nervous system. It also deals with measurements of BDNF levels and highlights recent findings from our laboratory on TrkB and TrkC signalling in human neurons. These include ligand selectivity and Trk activation by neurotrophins and non-neurotrophin ligands. The ligand-induced down-regulation and re-activation of Trk receptors is also discussed. |
| first_indexed | 2024-03-13T01:27:10Z |
| format | Article |
| id | doaj.art-705a98a135b640b6a7c5c0890eaf5ab7 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-03-13T01:27:10Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-705a98a135b640b6a7c5c0890eaf5ab72023-07-04T12:29:07ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992023-07-011610.3389/fnmol.2023.12253731225373Neurotrophin signalling in the human nervous systemSarah AteaqueSpyros MerkourisYves-Alain BardeThis review focuses on neurotrophins and their tyrosine kinase receptors, with an emphasis on their relevance to the function and dysfunction in the human nervous system. It also deals with measurements of BDNF levels and highlights recent findings from our laboratory on TrkB and TrkC signalling in human neurons. These include ligand selectivity and Trk activation by neurotrophins and non-neurotrophin ligands. The ligand-induced down-regulation and re-activation of Trk receptors is also discussed.https://www.frontiersin.org/articles/10.3389/fnmol.2023.1225373/fullNeurotrophins (NTs)Trk receptorsmemorydepressionneurodegenerationblood platelets |
| spellingShingle | Sarah Ateaque Spyros Merkouris Yves-Alain Barde Neurotrophin signalling in the human nervous system Frontiers in Molecular Neuroscience Neurotrophins (NTs) Trk receptors memory depression neurodegeneration blood platelets |
| title | Neurotrophin signalling in the human nervous system |
| title_full | Neurotrophin signalling in the human nervous system |
| title_fullStr | Neurotrophin signalling in the human nervous system |
| title_full_unstemmed | Neurotrophin signalling in the human nervous system |
| title_short | Neurotrophin signalling in the human nervous system |
| title_sort | neurotrophin signalling in the human nervous system |
| topic | Neurotrophins (NTs) Trk receptors memory depression neurodegeneration blood platelets |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1225373/full |
| work_keys_str_mv | AT sarahateaque neurotrophinsignallinginthehumannervoussystem AT spyrosmerkouris neurotrophinsignallinginthehumannervoussystem AT yvesalainbarde neurotrophinsignallinginthehumannervoussystem |