Primary Epstein–Barr Virus-Positive Mucocutaneous Ulcer of Esophagus: A Rare Case Report
Primary EBV-positive mucocutaneous ulcer (EBVMCU) is a rare and indolent disorder occurring in the oropharynx, skin, and gastrointestinal tract, with remission after removal of the immunosuppressive causes. We present a 69-year-old woman with heartburn, regurgitation of gastric acid, enlarged lymph...
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MDPI AG
2022-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/16/4915 |
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| author | Chunping Sun Qingya Wang Yujun Dong Lin Nong Yunlong Cai Lihong Wang Yuhua Sun Wensheng Wang Xinmin Liu |
| author_facet | Chunping Sun Qingya Wang Yujun Dong Lin Nong Yunlong Cai Lihong Wang Yuhua Sun Wensheng Wang Xinmin Liu |
| author_sort | Chunping Sun |
| collection | DOAJ |
| description | Primary EBV-positive mucocutaneous ulcer (EBVMCU) is a rare and indolent disorder occurring in the oropharynx, skin, and gastrointestinal tract, with remission after removal of the immunosuppressive causes. We present a 69-year-old woman with heartburn, regurgitation of gastric acid, enlarged lymph nodes, and parotid glands. The endoscopic examination showed a circumscribed ulcer in the lower esophagus. A biopsy pathology indicated an esophageal EBV-associated lymphoproliferative disorder and a parotid gland/lymph node indolent B-cell lymphoma. Interestingly, the patient did not undergo any treatment, but the endoscopic ulcer improved significantly after more than 2 months. The last pathology showed EBV negativity, and EBVMCU was considered in combination with clinical and endoscopic manifestations. We followed up with the patient at 6 months, and the symptoms of acid reflux and heartburn had disappeared. Our case demonstrates that EBVMCU may occur in the esophagus with spontaneous regression. |
| first_indexed | 2024-03-09T09:55:24Z |
| format | Article |
| id | doaj.art-705bffb3a4a44c71aee7d35a12dfd534 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T09:55:24Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-705bffb3a4a44c71aee7d35a12dfd5342023-12-01T23:51:01ZengMDPI AGJournal of Clinical Medicine2077-03832022-08-011116491510.3390/jcm11164915Primary Epstein–Barr Virus-Positive Mucocutaneous Ulcer of Esophagus: A Rare Case ReportChunping Sun0Qingya Wang1Yujun Dong2Lin Nong3Yunlong Cai4Lihong Wang5Yuhua Sun6Wensheng Wang7Xinmin Liu8Department of Geriatric, Peking University First Hospital, Peking University, Beijing 100034, ChinaDepartment of Hematology, Peking University First Hospital, Peking University, Beijing 100034, ChinaDepartment of Hematology, Peking University First Hospital, Peking University, Beijing 100034, ChinaDepartment of Pathology, Peking University First Hospital, Peking University, Beijing 100034, ChinaDepartment of Gastroenterology, Peking University First Hospital, Peking University, Beijing 100034, ChinaDepartment of Hematology, Peking University First Hospital, Peking University, Beijing 100034, ChinaDepartment of Hematology, Peking University First Hospital, Peking University, Beijing 100034, ChinaDepartment of Hematology, Peking University First Hospital, Peking University, Beijing 100034, ChinaDepartment of Geriatric, Peking University First Hospital, Peking University, Beijing 100034, ChinaPrimary EBV-positive mucocutaneous ulcer (EBVMCU) is a rare and indolent disorder occurring in the oropharynx, skin, and gastrointestinal tract, with remission after removal of the immunosuppressive causes. We present a 69-year-old woman with heartburn, regurgitation of gastric acid, enlarged lymph nodes, and parotid glands. The endoscopic examination showed a circumscribed ulcer in the lower esophagus. A biopsy pathology indicated an esophageal EBV-associated lymphoproliferative disorder and a parotid gland/lymph node indolent B-cell lymphoma. Interestingly, the patient did not undergo any treatment, but the endoscopic ulcer improved significantly after more than 2 months. The last pathology showed EBV negativity, and EBVMCU was considered in combination with clinical and endoscopic manifestations. We followed up with the patient at 6 months, and the symptoms of acid reflux and heartburn had disappeared. Our case demonstrates that EBVMCU may occur in the esophagus with spontaneous regression.https://www.mdpi.com/2077-0383/11/16/4915EBV-positive mucocutaneous ulceresophagusEBERPD-L1remission |
| spellingShingle | Chunping Sun Qingya Wang Yujun Dong Lin Nong Yunlong Cai Lihong Wang Yuhua Sun Wensheng Wang Xinmin Liu Primary Epstein–Barr Virus-Positive Mucocutaneous Ulcer of Esophagus: A Rare Case Report Journal of Clinical Medicine EBV-positive mucocutaneous ulcer esophagus EBER PD-L1 remission |
| title | Primary Epstein–Barr Virus-Positive Mucocutaneous Ulcer of Esophagus: A Rare Case Report |
| title_full | Primary Epstein–Barr Virus-Positive Mucocutaneous Ulcer of Esophagus: A Rare Case Report |
| title_fullStr | Primary Epstein–Barr Virus-Positive Mucocutaneous Ulcer of Esophagus: A Rare Case Report |
| title_full_unstemmed | Primary Epstein–Barr Virus-Positive Mucocutaneous Ulcer of Esophagus: A Rare Case Report |
| title_short | Primary Epstein–Barr Virus-Positive Mucocutaneous Ulcer of Esophagus: A Rare Case Report |
| title_sort | primary epstein barr virus positive mucocutaneous ulcer of esophagus a rare case report |
| topic | EBV-positive mucocutaneous ulcer esophagus EBER PD-L1 remission |
| url | https://www.mdpi.com/2077-0383/11/16/4915 |
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