Treatment Strategy and Research Progress of Immune Microenvironment for Liver Metastasis of Non-small Cell Lung Cancer
Liver is the common site for metastasis and spread of non-small cell lung cancer (NSCLC). Lung cancer patients with liver metastasis have poor prognosis, which may be related to liver-specific microenvironment composition. The metastasis of lung cancer to the liver is regulated by various pathophysi...
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2024-03-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://www.zlfzyj.com/en/article/doi/10.3971/j.issn.1000-8578.2024.23.0878 |
| _version_ | 1797206047009538048 |
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| author | SUN Jiaqi WANG Yudong |
| author_facet | SUN Jiaqi WANG Yudong |
| author_sort | SUN Jiaqi |
| collection | DOAJ |
| description | Liver is the common site for metastasis and spread of non-small cell lung cancer (NSCLC). Lung cancer patients with liver metastasis have poor prognosis, which may be related to liver-specific microenvironment composition. The metastasis of lung cancer to the liver is regulated by various pathophysiological factors, including the liver immune microenvironment, related cells, proteins, signaling molecules, and gene changes. These factors will affect the consistent disease process and subsequent treatment strategies. Immune checkpoint inhibitors (ICIs) have made breakthroughs in treatment of patients with advanced NSCLC. However, NSCLC patients with liver metastasis, a unique population of advanced lung cancer, are characterized by poor immunotherapeutic effect. This paper reviews the related mechanisms of the immune microenvironment in affecting the occurrence and development of liver metastases and summarizes the achievements and prospects of anti-tumor immunotherapy in liver metastases of NSCLC. |
| first_indexed | 2024-04-24T09:00:48Z |
| format | Article |
| id | doaj.art-705c4e0ff753482b9c0616ea6cfc4c80 |
| institution | Directory Open Access Journal |
| issn | 1000-8578 |
| language | zho |
| last_indexed | 2024-04-24T09:00:48Z |
| publishDate | 2024-03-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-705c4e0ff753482b9c0616ea6cfc4c802024-04-16T02:19:41ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782024-03-0151320320910.3971/j.issn.1000-8578.2024.23.0878zlfzyj-51-3-203Treatment Strategy and Research Progress of Immune Microenvironment for Liver Metastasis of Non-small Cell Lung CancerSUN Jiaqi0WANG Yudong1Department of Medical Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, ChinaDepartment of Medical Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, ChinaLiver is the common site for metastasis and spread of non-small cell lung cancer (NSCLC). Lung cancer patients with liver metastasis have poor prognosis, which may be related to liver-specific microenvironment composition. The metastasis of lung cancer to the liver is regulated by various pathophysiological factors, including the liver immune microenvironment, related cells, proteins, signaling molecules, and gene changes. These factors will affect the consistent disease process and subsequent treatment strategies. Immune checkpoint inhibitors (ICIs) have made breakthroughs in treatment of patients with advanced NSCLC. However, NSCLC patients with liver metastasis, a unique population of advanced lung cancer, are characterized by poor immunotherapeutic effect. This paper reviews the related mechanisms of the immune microenvironment in affecting the occurrence and development of liver metastases and summarizes the achievements and prospects of anti-tumor immunotherapy in liver metastases of NSCLC.http://www.zlfzyj.com/en/article/doi/10.3971/j.issn.1000-8578.2024.23.0878non-small cell lung cancerliver metastasisimmunotherapyimmune microenvironment |
| spellingShingle | SUN Jiaqi WANG Yudong Treatment Strategy and Research Progress of Immune Microenvironment for Liver Metastasis of Non-small Cell Lung Cancer Zhongliu Fangzhi Yanjiu non-small cell lung cancer liver metastasis immunotherapy immune microenvironment |
| title | Treatment Strategy and Research Progress of Immune Microenvironment for Liver Metastasis of Non-small Cell Lung Cancer |
| title_full | Treatment Strategy and Research Progress of Immune Microenvironment for Liver Metastasis of Non-small Cell Lung Cancer |
| title_fullStr | Treatment Strategy and Research Progress of Immune Microenvironment for Liver Metastasis of Non-small Cell Lung Cancer |
| title_full_unstemmed | Treatment Strategy and Research Progress of Immune Microenvironment for Liver Metastasis of Non-small Cell Lung Cancer |
| title_short | Treatment Strategy and Research Progress of Immune Microenvironment for Liver Metastasis of Non-small Cell Lung Cancer |
| title_sort | treatment strategy and research progress of immune microenvironment for liver metastasis of non small cell lung cancer |
| topic | non-small cell lung cancer liver metastasis immunotherapy immune microenvironment |
| url | http://www.zlfzyj.com/en/article/doi/10.3971/j.issn.1000-8578.2024.23.0878 |
| work_keys_str_mv | AT sunjiaqi treatmentstrategyandresearchprogressofimmunemicroenvironmentforlivermetastasisofnonsmallcelllungcancer AT wangyudong treatmentstrategyandresearchprogressofimmunemicroenvironmentforlivermetastasisofnonsmallcelllungcancer |