Blocking Polyphosphate Mobilization Inhibits Pho4 Activation and Virulence in the Pathogen Candida albicans

Blocking Polyphosphate Mobilization Inhibits Pho4 Activation and Virulence in the Pathogen Candida albicans

ABSTRACT The ability of pathogenic fungi to obtain essential nutrients from the host is vital for virulence. In Candida albicans, acquisition of the macronutrient phosphate is regulated by the Pho4 transcription factor and is important for both virulence and resistance to host-encountered stresses....

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Bibliographic Details
Main Authors: Yasmin Ahmed, Mélanie A. C. Ikeh, Donna M. MacCallum, Alison M. Day, Kevin Waldron, Janet Quinn
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:mBio
Subjects:
Candida albicans
morphogenesis
phosphate metabolism
stress response
virulence
Online Access:https://journals.asm.org/doi/10.1128/mbio.00342-22

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