The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia
New treatments are urgently needed for serious mental illnesses including bipolar disorder and schizophrenia. This review proposes that Garcinia mangostana Linn. (mangosteen) pericarp is a possible adjunctive therapeutic agent for these disorders. Research to date demonstrates that neurobiological p...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00115/full |
| _version_ | 1819086373146066944 |
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| author | Melanie M. Ashton Melanie M. Ashton Melanie M. Ashton Olivia M. Dean Olivia M. Dean Olivia M. Dean Adam J. Walker Chiara C. Bortolasci Chee H. Ng Malcolm Hopwood Brian H. Harvey Marisa Möller John J. McGrath John J. McGrath John J. McGrath Wolfgang Marx Alyna Turner Alyna Turner Seetal Dodd Seetal Dodd Seetal Dodd James G. Scott James G. Scott James G. Scott Jon-Paul Khoo Jon-Paul Khoo Ken Walder Jerome Sarris Jerome Sarris Michael Berk Michael Berk Michael Berk Michael Berk Michael Berk |
| author_facet | Melanie M. Ashton Melanie M. Ashton Melanie M. Ashton Olivia M. Dean Olivia M. Dean Olivia M. Dean Adam J. Walker Chiara C. Bortolasci Chee H. Ng Malcolm Hopwood Brian H. Harvey Marisa Möller John J. McGrath John J. McGrath John J. McGrath Wolfgang Marx Alyna Turner Alyna Turner Seetal Dodd Seetal Dodd Seetal Dodd James G. Scott James G. Scott James G. Scott Jon-Paul Khoo Jon-Paul Khoo Ken Walder Jerome Sarris Jerome Sarris Michael Berk Michael Berk Michael Berk Michael Berk Michael Berk |
| author_sort | Melanie M. Ashton |
| collection | DOAJ |
| description | New treatments are urgently needed for serious mental illnesses including bipolar disorder and schizophrenia. This review proposes that Garcinia mangostana Linn. (mangosteen) pericarp is a possible adjunctive therapeutic agent for these disorders. Research to date demonstrates that neurobiological properties of the mangosteen pericarp are well aligned with the current understanding of the pathophysiology of bipolar disorder and schizophrenia. Mangosteen pericarp has antioxidant, putative neuroprotective, anti-inflammatory, and putative mitochondrial enhancing properties, with animal studies demonstrating favorable pharmacotherapeutic benefits with respect to these disorders. This review summarizes evidence of its properties and supports the case for future studies to assess the utility of mangosteen pericarp as an adjunctive treatment option for mood and psychotic disorders. |
| first_indexed | 2024-12-21T21:19:13Z |
| format | Article |
| id | doaj.art-7062924ffbd6412fa2f07e4e889c0aa9 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-21T21:19:13Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-7062924ffbd6412fa2f07e4e889c0aa92022-12-21T18:49:56ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402019-03-011010.3389/fpsyt.2019.00115422189The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and SchizophreniaMelanie M. Ashton0Melanie M. Ashton1Melanie M. Ashton2Olivia M. Dean3Olivia M. Dean4Olivia M. Dean5Adam J. Walker6Chiara C. Bortolasci7Chee H. Ng8Malcolm Hopwood9Brian H. Harvey10Marisa Möller11John J. McGrath12John J. McGrath13John J. McGrath14Wolfgang Marx15Alyna Turner16Alyna Turner17Seetal Dodd18Seetal Dodd19Seetal Dodd20James G. Scott21James G. Scott22James G. Scott23Jon-Paul Khoo24Jon-Paul Khoo25Ken Walder26Jerome Sarris27Jerome Sarris28Michael Berk29Michael Berk30Michael Berk31Michael Berk32Michael Berk33IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, AustraliaFlorey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, AustraliaProfessorial Unit, The Melbourne Clinic, Department of Psychiatry, University of Melbourne, Richmond, VIC, AustraliaIMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, AustraliaFlorey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, AustraliaDepartment of Psychiatry, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, AustraliaIMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, AustraliaCentre for Molecular and Medical Research, School of Medicine, Deakin University, Geelong, VIC, AustraliaProfessorial Unit, The Melbourne Clinic, Department of Psychiatry, University of Melbourne, Richmond, VIC, AustraliaProfessorial Psychiatry Unit, Albert Road Clinic, University of Melbourne, Melbourne, VIC, AustraliaCentre of Excellence for Pharmaceutical Sciences, School of Pharmacy (Pharmacology), North West University, Potchefstroom, South AfricaCentre of Excellence for Pharmaceutical Sciences, School of Pharmacy (Pharmacology), North West University, Potchefstroom, South AfricaQueensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, AustraliaQueensland Brain Institute, University of Queensland, St. Lucia, QLD, Australia0National Centre for Register-Based Research, Aarhus University, Aarhus, DenmarkIMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, AustraliaIMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, AustraliaDepartment of Psychiatry, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, AustraliaIMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, AustraliaDepartment of Psychiatry, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia1Centre of Youth Mental Health, University of Melbourne, Parkville, VIC, AustraliaQueensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, Australia2Faculty of Medicine, The University of Queensland, Herston, QLD, Australia3Metro North Mental Health, Royal Brisbane and Women's Hospital, Brisbane, QLD, AustraliaIMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia2Faculty of Medicine, The University of Queensland, Herston, QLD, AustraliaCentre for Molecular and Medical Research, School of Medicine, Deakin University, Geelong, VIC, AustraliaProfessorial Unit, The Melbourne Clinic, Department of Psychiatry, University of Melbourne, Richmond, VIC, Australia4NICM Health Research Institute, Western Sydney University, Westmead, NSW, AustraliaIMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, AustraliaFlorey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, AustraliaDepartment of Psychiatry, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia1Centre of Youth Mental Health, University of Melbourne, Parkville, VIC, Australia5Orygen Youth Health Research Centre, Parkville, VIC, AustraliaNew treatments are urgently needed for serious mental illnesses including bipolar disorder and schizophrenia. This review proposes that Garcinia mangostana Linn. (mangosteen) pericarp is a possible adjunctive therapeutic agent for these disorders. Research to date demonstrates that neurobiological properties of the mangosteen pericarp are well aligned with the current understanding of the pathophysiology of bipolar disorder and schizophrenia. Mangosteen pericarp has antioxidant, putative neuroprotective, anti-inflammatory, and putative mitochondrial enhancing properties, with animal studies demonstrating favorable pharmacotherapeutic benefits with respect to these disorders. This review summarizes evidence of its properties and supports the case for future studies to assess the utility of mangosteen pericarp as an adjunctive treatment option for mood and psychotic disorders.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00115/fullmangosteen pericarpbipolar disorderschizophreniapsychiatryoxidative stressinflammation |
| spellingShingle | Melanie M. Ashton Melanie M. Ashton Melanie M. Ashton Olivia M. Dean Olivia M. Dean Olivia M. Dean Adam J. Walker Chiara C. Bortolasci Chee H. Ng Malcolm Hopwood Brian H. Harvey Marisa Möller John J. McGrath John J. McGrath John J. McGrath Wolfgang Marx Alyna Turner Alyna Turner Seetal Dodd Seetal Dodd Seetal Dodd James G. Scott James G. Scott James G. Scott Jon-Paul Khoo Jon-Paul Khoo Ken Walder Jerome Sarris Jerome Sarris Michael Berk Michael Berk Michael Berk Michael Berk Michael Berk The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia Frontiers in Psychiatry mangosteen pericarp bipolar disorder schizophrenia psychiatry oxidative stress inflammation |
| title | The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia |
| title_full | The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia |
| title_fullStr | The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia |
| title_full_unstemmed | The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia |
| title_short | The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia |
| title_sort | therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia |
| topic | mangosteen pericarp bipolar disorder schizophrenia psychiatry oxidative stress inflammation |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00115/full |
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