Relationship between CRP gene polymorphisms and ischemic stroke risk: A systematic review and meta-analysis
Ischemic stroke (IS), usually caused due to an abrupt blockage of an artery, is the leading cause of disability and the second leading cause of death worldwide. The association of the C-reactive protein (CRP) gene (s3093059 T/C and rs1205 C/T) polymorphisms and IS susceptibility has been widely stud...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-11-01
|
| Series: | Open Life Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/biol-2022-0505 |
| _version_ | 1798014074953400320 |
|---|---|
| author | Chen Zhizhi Jiang Feifei Yang Ming Yang Jie |
| author_facet | Chen Zhizhi Jiang Feifei Yang Ming Yang Jie |
| author_sort | Chen Zhizhi |
| collection | DOAJ |
| description | Ischemic stroke (IS), usually caused due to an abrupt blockage of an artery, is the leading cause of disability and the second leading cause of death worldwide. The association of the C-reactive protein (CRP) gene (s3093059 T/C and rs1205 C/T) polymorphisms and IS susceptibility has been widely studied, but the results remain inconsistent. Our study aimed to assess the association between CRP gene (s3093059 T/C and rs1205 C/T) polymorphisms and IS risk. PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, and WanFang databases were searched up to April 2022 to identify eligible studies. The Newcastle-Ottawa scale (NOS) score was calculated to assess study quality. The odd ratios (ORs) with a 95% confidence interval (CI) were calculated to assess the association between CRP gene (rs3093059 T/C and rs1205 C/T) polymorphisms and IS risk. Eighteen case–control studies with 6339 cases and 29580 controls were identified. We found that CRP (s3093059 T/C and rs1205 C/T) polymorphism was not significantly associated with the risk of IS in any genetic model (recessive model: OR 1.00, 95% CI 0.79–1.26; OR 1.06, 95% CI 0.90–1.25). When stratified analysis by country, genotype method, source of controls, and NOS score, still no statistically significant association was found. Our study indicated that the CRP (rs3093059 T/C and rs1205 C/T) polymorphisms were not associated with the susceptibility to IS. |
| first_indexed | 2024-04-11T15:12:45Z |
| format | Article |
| id | doaj.art-7065840db1f84d4fab724ad67eebd903 |
| institution | Directory Open Access Journal |
| issn | 2391-5412 |
| language | English |
| last_indexed | 2024-04-11T15:12:45Z |
| publishDate | 2022-11-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj.art-7065840db1f84d4fab724ad67eebd9032022-12-22T04:16:36ZengDe GruyterOpen Life Sciences2391-54122022-11-011711519153010.1515/biol-2022-0505Relationship between CRP gene polymorphisms and ischemic stroke risk: A systematic review and meta-analysisChen Zhizhi0Jiang Feifei1Yang Ming2Yang Jie3Department of Neurology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou 324000, Zhejiang, ChinaDepartment of Neurology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou 324000, Zhejiang, ChinaDepartment of Neurology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou 324000, Zhejiang, ChinaDepartment of Rehabilitation Medicine, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, 100 Minjiang Road, Quzhou 324000, Zhejiang, ChinaIschemic stroke (IS), usually caused due to an abrupt blockage of an artery, is the leading cause of disability and the second leading cause of death worldwide. The association of the C-reactive protein (CRP) gene (s3093059 T/C and rs1205 C/T) polymorphisms and IS susceptibility has been widely studied, but the results remain inconsistent. Our study aimed to assess the association between CRP gene (s3093059 T/C and rs1205 C/T) polymorphisms and IS risk. PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, and WanFang databases were searched up to April 2022 to identify eligible studies. The Newcastle-Ottawa scale (NOS) score was calculated to assess study quality. The odd ratios (ORs) with a 95% confidence interval (CI) were calculated to assess the association between CRP gene (rs3093059 T/C and rs1205 C/T) polymorphisms and IS risk. Eighteen case–control studies with 6339 cases and 29580 controls were identified. We found that CRP (s3093059 T/C and rs1205 C/T) polymorphism was not significantly associated with the risk of IS in any genetic model (recessive model: OR 1.00, 95% CI 0.79–1.26; OR 1.06, 95% CI 0.90–1.25). When stratified analysis by country, genotype method, source of controls, and NOS score, still no statistically significant association was found. Our study indicated that the CRP (rs3093059 T/C and rs1205 C/T) polymorphisms were not associated with the susceptibility to IS.https://doi.org/10.1515/biol-2022-0505ischemic strokec-reactive proteinpolymorphismmeta-analysis |
| spellingShingle | Chen Zhizhi Jiang Feifei Yang Ming Yang Jie Relationship between CRP gene polymorphisms and ischemic stroke risk: A systematic review and meta-analysis Open Life Sciences ischemic stroke c-reactive protein polymorphism meta-analysis |
| title | Relationship between CRP gene polymorphisms and ischemic stroke risk: A systematic review and meta-analysis |
| title_full | Relationship between CRP gene polymorphisms and ischemic stroke risk: A systematic review and meta-analysis |
| title_fullStr | Relationship between CRP gene polymorphisms and ischemic stroke risk: A systematic review and meta-analysis |
| title_full_unstemmed | Relationship between CRP gene polymorphisms and ischemic stroke risk: A systematic review and meta-analysis |
| title_short | Relationship between CRP gene polymorphisms and ischemic stroke risk: A systematic review and meta-analysis |
| title_sort | relationship between crp gene polymorphisms and ischemic stroke risk a systematic review and meta analysis |
| topic | ischemic stroke c-reactive protein polymorphism meta-analysis |
| url | https://doi.org/10.1515/biol-2022-0505 |
| work_keys_str_mv | AT chenzhizhi relationshipbetweencrpgenepolymorphismsandischemicstrokeriskasystematicreviewandmetaanalysis AT jiangfeifei relationshipbetweencrpgenepolymorphismsandischemicstrokeriskasystematicreviewandmetaanalysis AT yangming relationshipbetweencrpgenepolymorphismsandischemicstrokeriskasystematicreviewandmetaanalysis AT yangjie relationshipbetweencrpgenepolymorphismsandischemicstrokeriskasystematicreviewandmetaanalysis |