A Perspective on the Development of c-Jun N-terminal Kinase Inhibitors as Therapeutics for Alzheimer’s Disease: Investigating Structure through Docking Studies
c-Jun N-terminal kinase (JNK) plays an important role in cell death caused by various stimuli. Because the isoform JNK3 is mainly expressed in the brain, it is believed to play a pivotal role in various neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD), whic...
| Κύριοι συγγραφείς: | , |
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| Μορφή: | Άρθρο |
| Γλώσσα: | English |
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MDPI AG
2021-10-01
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| Σειρά: | Biomedicines |
| Θέματα: | |
| Διαθέσιμο Online: | https://www.mdpi.com/2227-9059/9/10/1431 |
| _version_ | 1827680041393192960 |
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| author | Hyunwook Cho Jung-Mi Hah |
| author_facet | Hyunwook Cho Jung-Mi Hah |
| author_sort | Hyunwook Cho |
| collection | DOAJ |
| description | c-Jun N-terminal kinase (JNK) plays an important role in cell death caused by various stimuli. Because the isoform JNK3 is mainly expressed in the brain, it is believed to play a pivotal role in various neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD), which still lack plausible therapeutics. To develop a novel and selective JNK3 inhibitor, we conducted a decadal review (2011 to 2021) of published articles on JNK inhibitors, particularly those focusing on a structural perspective and docking insights. We observed the structures of three isoforms of JNK, namely holo-proteins and co-crystal structures, with JNK3 inhibitors and summarized the significant structural aspects of selective JNK3 inhibitors as AD therapeutics. |
| first_indexed | 2024-03-10T06:42:28Z |
| format | Article |
| id | doaj.art-7066b2a32df9438383742b52a2ccf542 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T06:42:28Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-7066b2a32df9438383742b52a2ccf5422023-11-22T17:31:47ZengMDPI AGBiomedicines2227-90592021-10-01910143110.3390/biomedicines9101431A Perspective on the Development of c-Jun N-terminal Kinase Inhibitors as Therapeutics for Alzheimer’s Disease: Investigating Structure through Docking StudiesHyunwook Cho0Jung-Mi Hah1Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan 15588, KoreaDepartment of Pharmacy, College of Pharmacy, Hanyang University, Ansan 15588, Koreac-Jun N-terminal kinase (JNK) plays an important role in cell death caused by various stimuli. Because the isoform JNK3 is mainly expressed in the brain, it is believed to play a pivotal role in various neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD), which still lack plausible therapeutics. To develop a novel and selective JNK3 inhibitor, we conducted a decadal review (2011 to 2021) of published articles on JNK inhibitors, particularly those focusing on a structural perspective and docking insights. We observed the structures of three isoforms of JNK, namely holo-proteins and co-crystal structures, with JNK3 inhibitors and summarized the significant structural aspects of selective JNK3 inhibitors as AD therapeutics.https://www.mdpi.com/2227-9059/9/10/1431Alzheimer’s diseasec-Jun N-terminal kinasesmall-molecule protein kinase inhibitorJNK3selectivity |
| spellingShingle | Hyunwook Cho Jung-Mi Hah A Perspective on the Development of c-Jun N-terminal Kinase Inhibitors as Therapeutics for Alzheimer’s Disease: Investigating Structure through Docking Studies Biomedicines Alzheimer’s disease c-Jun N-terminal kinase small-molecule protein kinase inhibitor JNK3 selectivity |
| title | A Perspective on the Development of c-Jun N-terminal Kinase Inhibitors as Therapeutics for Alzheimer’s Disease: Investigating Structure through Docking Studies |
| title_full | A Perspective on the Development of c-Jun N-terminal Kinase Inhibitors as Therapeutics for Alzheimer’s Disease: Investigating Structure through Docking Studies |
| title_fullStr | A Perspective on the Development of c-Jun N-terminal Kinase Inhibitors as Therapeutics for Alzheimer’s Disease: Investigating Structure through Docking Studies |
| title_full_unstemmed | A Perspective on the Development of c-Jun N-terminal Kinase Inhibitors as Therapeutics for Alzheimer’s Disease: Investigating Structure through Docking Studies |
| title_short | A Perspective on the Development of c-Jun N-terminal Kinase Inhibitors as Therapeutics for Alzheimer’s Disease: Investigating Structure through Docking Studies |
| title_sort | perspective on the development of c jun n terminal kinase inhibitors as therapeutics for alzheimer s disease investigating structure through docking studies |
| topic | Alzheimer’s disease c-Jun N-terminal kinase small-molecule protein kinase inhibitor JNK3 selectivity |
| url | https://www.mdpi.com/2227-9059/9/10/1431 |
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