Atypical miller-fisher syndrome after COVID-19 and sleeve gastrectomy: Contribution of neurochemical markers to early diagnosis
Background: The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), began in late 2019. More recently, there have been sporadic case reports on development of Miller-Fisher Syndrome , a rare variant of Guillain-Barré Syndrome in COVID...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Infectious Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772431X22000053 |
| _version_ | 1827373913260163072 |
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| author | Souheil Zayet Hajer Zahra Nabil Belfeki Timothée Klopfenstein Beate Hagenkötter |
| author_facet | Souheil Zayet Hajer Zahra Nabil Belfeki Timothée Klopfenstein Beate Hagenkötter |
| author_sort | Souheil Zayet |
| collection | DOAJ |
| description | Background: The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), began in late 2019. More recently, there have been sporadic case reports on development of Miller-Fisher Syndrome , a rare variant of Guillain-Barré Syndrome in COVID-19 patients. Case report: We reported herein the case of a French young women presenting with ophtalmoplegia, cerebellar ataxia, and universal areflexia following a bariatric surgery (sleeve gastrectomy). A concomitant COVID-19 diagnosis was retained based on microbiological testing. The patient was successfully treated after high-dose intravenous thiamine, but areflexia persisted. Underlying COVID-19 related Miller-Fisher Syndrome was established on physical examination and confirmed by pathologic neurophysiological findings and elevated level of phosphorylated neurofilament heavy chain protein in cerebrospinal fluid analysis. Conclusions: Guillain-Barré Syndrome and its variants after SARS-CoV-2 infection are extremely rare. The measurement of phosphorylated neurofilament heavy chain protein should be considered as an easy tool to detect an early affection of the peripheral nervous system. |
| first_indexed | 2024-03-08T11:24:44Z |
| format | Article |
| id | doaj.art-7066e5d465d74e368fe4fa7521226b7d |
| institution | Directory Open Access Journal |
| issn | 2772-431X |
| language | English |
| last_indexed | 2024-03-08T11:24:44Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Infectious Medicine |
| spelling | doaj.art-7066e5d465d74e368fe4fa7521226b7d2024-01-26T05:35:53ZengElsevierInfectious Medicine2772-431X2022-06-0112140142Atypical miller-fisher syndrome after COVID-19 and sleeve gastrectomy: Contribution of neurochemical markers to early diagnosisSouheil Zayet0Hajer Zahra1Nabil Belfeki2Timothée Klopfenstein3Beate Hagenkötter4Infectious Diseases Department, Nord Franche-Comté Hospital, France; Corresponding author.Diabetology Department, Nord Franche-Comté Hospital, FranceInternal Medicine Department, Groupe Hospitalier Sud Ile de France, Melun, FranceInfectious Diseases Department, Nord Franche-Comté Hospital, FranceNeurology Department, Nord Franche-Comté Hospital, FranceBackground: The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), began in late 2019. More recently, there have been sporadic case reports on development of Miller-Fisher Syndrome , a rare variant of Guillain-Barré Syndrome in COVID-19 patients. Case report: We reported herein the case of a French young women presenting with ophtalmoplegia, cerebellar ataxia, and universal areflexia following a bariatric surgery (sleeve gastrectomy). A concomitant COVID-19 diagnosis was retained based on microbiological testing. The patient was successfully treated after high-dose intravenous thiamine, but areflexia persisted. Underlying COVID-19 related Miller-Fisher Syndrome was established on physical examination and confirmed by pathologic neurophysiological findings and elevated level of phosphorylated neurofilament heavy chain protein in cerebrospinal fluid analysis. Conclusions: Guillain-Barré Syndrome and its variants after SARS-CoV-2 infection are extremely rare. The measurement of phosphorylated neurofilament heavy chain protein should be considered as an easy tool to detect an early affection of the peripheral nervous system.http://www.sciencedirect.com/science/article/pii/S2772431X22000053COVID-19Miller-fisher syndromeWernicke encephalopathyBariatric surgeryPhosphorylated neurofilament heavy chain Protein |
| spellingShingle | Souheil Zayet Hajer Zahra Nabil Belfeki Timothée Klopfenstein Beate Hagenkötter Atypical miller-fisher syndrome after COVID-19 and sleeve gastrectomy: Contribution of neurochemical markers to early diagnosis Infectious Medicine COVID-19 Miller-fisher syndrome Wernicke encephalopathy Bariatric surgery Phosphorylated neurofilament heavy chain Protein |
| title | Atypical miller-fisher syndrome after COVID-19 and sleeve gastrectomy: Contribution of neurochemical markers to early diagnosis |
| title_full | Atypical miller-fisher syndrome after COVID-19 and sleeve gastrectomy: Contribution of neurochemical markers to early diagnosis |
| title_fullStr | Atypical miller-fisher syndrome after COVID-19 and sleeve gastrectomy: Contribution of neurochemical markers to early diagnosis |
| title_full_unstemmed | Atypical miller-fisher syndrome after COVID-19 and sleeve gastrectomy: Contribution of neurochemical markers to early diagnosis |
| title_short | Atypical miller-fisher syndrome after COVID-19 and sleeve gastrectomy: Contribution of neurochemical markers to early diagnosis |
| title_sort | atypical miller fisher syndrome after covid 19 and sleeve gastrectomy contribution of neurochemical markers to early diagnosis |
| topic | COVID-19 Miller-fisher syndrome Wernicke encephalopathy Bariatric surgery Phosphorylated neurofilament heavy chain Protein |
| url | http://www.sciencedirect.com/science/article/pii/S2772431X22000053 |
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