Anti-inflammatory effects of hunger are transmitted to the periphery via projection-specific AgRP circuits
Summary: Caloric restriction has anti-inflammatory effects. However, the coordinated physiological actions that lead to reduced inflammation in a state of caloric deficit (hunger) are largely unknown. Using a mouse model of injury-induced peripheral inflammation, we find that food deprivation reduce...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723013505 |
| _version_ | 1797448055505551360 |
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| author | Michelle L. Klima Kayla A. Kruger Nitsan Goldstein Santiago Pulido Aloysius Y.T. Low Charles-Antoine Assenmacher Amber L. Alhadeff J. Nicholas Betley |
| author_facet | Michelle L. Klima Kayla A. Kruger Nitsan Goldstein Santiago Pulido Aloysius Y.T. Low Charles-Antoine Assenmacher Amber L. Alhadeff J. Nicholas Betley |
| author_sort | Michelle L. Klima |
| collection | DOAJ |
| description | Summary: Caloric restriction has anti-inflammatory effects. However, the coordinated physiological actions that lead to reduced inflammation in a state of caloric deficit (hunger) are largely unknown. Using a mouse model of injury-induced peripheral inflammation, we find that food deprivation reduces edema, temperature, and cytokine responses that occur after injury. The magnitude of the anti-inflammatory effect that occurs during hunger is more robust than that of non-steroidal anti-inflammatory drugs. The effects of hunger are recapitulated centrally by activity in nutrient-sensing hypothalamic agouti-related protein (AgRP)-expressing neurons. We find that AgRP neurons projecting to the paraventricular nucleus of the hypothalamus rapidly and robustly reduce inflammation and mediate the majority of hunger’s anti-inflammatory effects. Intact vagal efferent signaling is required for the anti-inflammatory action of hunger, revealing a brain-to-periphery pathway for this reduction in inflammation. Taken together, these data begin to unravel a potent anti-inflammatory pathway engaged by hypothalamic AgRP neurons to reduce inflammation. |
| first_indexed | 2024-03-09T14:05:54Z |
| format | Article |
| id | doaj.art-706905b9a93e48a9811f41ed68326f6b |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-09T14:05:54Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-706905b9a93e48a9811f41ed68326f6b2023-11-30T05:06:51ZengElsevierCell Reports2211-12472023-11-014211113338Anti-inflammatory effects of hunger are transmitted to the periphery via projection-specific AgRP circuitsMichelle L. Klima0Kayla A. Kruger1Nitsan Goldstein2Santiago Pulido3Aloysius Y.T. Low4Charles-Antoine Assenmacher5Amber L. Alhadeff6J. Nicholas Betley7Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104, USAComparative Pathology Core, Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USADepartment of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA; Monell Chemical Senses Center, Philadelphia, PA 19104, USA; Corresponding authorDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA; Corresponding authorSummary: Caloric restriction has anti-inflammatory effects. However, the coordinated physiological actions that lead to reduced inflammation in a state of caloric deficit (hunger) are largely unknown. Using a mouse model of injury-induced peripheral inflammation, we find that food deprivation reduces edema, temperature, and cytokine responses that occur after injury. The magnitude of the anti-inflammatory effect that occurs during hunger is more robust than that of non-steroidal anti-inflammatory drugs. The effects of hunger are recapitulated centrally by activity in nutrient-sensing hypothalamic agouti-related protein (AgRP)-expressing neurons. We find that AgRP neurons projecting to the paraventricular nucleus of the hypothalamus rapidly and robustly reduce inflammation and mediate the majority of hunger’s anti-inflammatory effects. Intact vagal efferent signaling is required for the anti-inflammatory action of hunger, revealing a brain-to-periphery pathway for this reduction in inflammation. Taken together, these data begin to unravel a potent anti-inflammatory pathway engaged by hypothalamic AgRP neurons to reduce inflammation.http://www.sciencedirect.com/science/article/pii/S2211124723013505CP: Neuroscience |
| spellingShingle | Michelle L. Klima Kayla A. Kruger Nitsan Goldstein Santiago Pulido Aloysius Y.T. Low Charles-Antoine Assenmacher Amber L. Alhadeff J. Nicholas Betley Anti-inflammatory effects of hunger are transmitted to the periphery via projection-specific AgRP circuits Cell Reports CP: Neuroscience |
| title | Anti-inflammatory effects of hunger are transmitted to the periphery via projection-specific AgRP circuits |
| title_full | Anti-inflammatory effects of hunger are transmitted to the periphery via projection-specific AgRP circuits |
| title_fullStr | Anti-inflammatory effects of hunger are transmitted to the periphery via projection-specific AgRP circuits |
| title_full_unstemmed | Anti-inflammatory effects of hunger are transmitted to the periphery via projection-specific AgRP circuits |
| title_short | Anti-inflammatory effects of hunger are transmitted to the periphery via projection-specific AgRP circuits |
| title_sort | anti inflammatory effects of hunger are transmitted to the periphery via projection specific agrp circuits |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723013505 |
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