Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum
Chemical investigations on the Dongsha Atoll soft coral Lobophytum crassum led to the purification of a new seco-cembranoid, secocrassumol. The structural elucidation was established by extensive NMR, HRESIMS and CD data. The absolute configuration at C-12 was determined as S using a modified Mosher...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2014-12-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/12/12/6028 |
| _version_ | 1811302305895546880 |
|---|---|
| author | Shi-Yie Cheng Shang-Kwei Wang Chang-Yih Duh |
| author_facet | Shi-Yie Cheng Shang-Kwei Wang Chang-Yih Duh |
| author_sort | Shi-Yie Cheng |
| collection | DOAJ |
| description | Chemical investigations on the Dongsha Atoll soft coral Lobophytum crassum led to the purification of a new seco-cembranoid, secocrassumol. The structural elucidation was established by extensive NMR, HRESIMS and CD data. The absolute configuration at C-12 was determined as S using a modified Mosher’s acylation. Secocrassumol differs from previously known marine seco-cembranoid in that it possesses an unprecedented skeleton functionalized at C11-C12 bond cleavage. Secocrassumol showed antiviral activity against human cytomegalovirus (HCMV) with an IC50 value of 5.0 μg/mL. |
| first_indexed | 2024-04-13T07:27:01Z |
| format | Article |
| id | doaj.art-706da7e4adb24cdd92bbacde8bf2944b |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-13T07:27:01Z |
| publishDate | 2014-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-706da7e4adb24cdd92bbacde8bf2944b2022-12-22T02:56:28ZengMDPI AGMarine Drugs1660-33972014-12-0112126028603710.3390/md12126028md12126028Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassumShi-Yie Cheng0Shang-Kwei Wang1Chang-Yih Duh2Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, TaiwanDepartment of Microbiology, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, TaiwanChemical investigations on the Dongsha Atoll soft coral Lobophytum crassum led to the purification of a new seco-cembranoid, secocrassumol. The structural elucidation was established by extensive NMR, HRESIMS and CD data. The absolute configuration at C-12 was determined as S using a modified Mosher’s acylation. Secocrassumol differs from previously known marine seco-cembranoid in that it possesses an unprecedented skeleton functionalized at C11-C12 bond cleavage. Secocrassumol showed antiviral activity against human cytomegalovirus (HCMV) with an IC50 value of 5.0 μg/mL.http://www.mdpi.com/1660-3397/12/12/6028Lobophytum crassumseco-cembranoidMosher’s acylationantiviral activity |
| spellingShingle | Shi-Yie Cheng Shang-Kwei Wang Chang-Yih Duh Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum Marine Drugs Lobophytum crassum seco-cembranoid Mosher’s acylation antiviral activity |
| title | Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum |
| title_full | Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum |
| title_fullStr | Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum |
| title_full_unstemmed | Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum |
| title_short | Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum |
| title_sort | secocrassumol a seco cembranoid from the dongsha atoll soft coral lobophytum crassum |
| topic | Lobophytum crassum seco-cembranoid Mosher’s acylation antiviral activity |
| url | http://www.mdpi.com/1660-3397/12/12/6028 |
| work_keys_str_mv | AT shiyiecheng secocrassumolasecocembranoidfromthedongshaatollsoftcorallobophytumcrassum AT shangkweiwang secocrassumolasecocembranoidfromthedongshaatollsoftcorallobophytumcrassum AT changyihduh secocrassumolasecocembranoidfromthedongshaatollsoftcorallobophytumcrassum |