QuantiFERON-TB Gold Plus Assay in Patients With Latent vs. Active Tuberculosis in a Low Incidence Setting: Level of IFN-γ, CD4/CD8 Responses, and Release of IL-2, IP-10, and MIG

QuantiFERON-TB Gold Plus Assay in Patients With Latent vs. Active Tuberculosis in a Low Incidence Setting: Level of IFN-γ, CD4/CD8 Responses, and Release of IL-2, IP-10, and MIG

ObjectivesWe analyzed the results of the QuantiFERON Glod Plus assay (QFT) and cytokine patterns associated with active tuberculosis (ATB) among patients with positive QFT.MethodsA total of 195 patients are QFT-positive, among which 24 had an ATB and 171 had a latent tuberculosis infection (LTBI). I...

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Bibliographic Details
Main Authors: Séverine Carrère-Kremer, Pratt Kolia-Diafouka, Amandine Pisoni, Karine Bolloré, Marianne Peries, Sylvain Godreuil, Arnaud Bourdin, Philippe Van de Perre, Edouard Tuaillon
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Microbiology
Subjects:
tuberculosis
QuantiFERON TB Gold plus®
IL-2
IP-10 (CXCL-10)
latent tuberculosis
active tuberculosis
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.825021/full

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