Relevance of Autophagy Induction by Gastrointestinal Hormones: Focus on the Incretin-Based Drug Target and Glucagon
The biology of autophagy in health and disease conditions has been intensively analyzed for decades. Several potential interventions can induce autophagy in preclinical research; however, none of these interventions are ready for translation to clinical practice yet. The topic of the current review...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-05-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2019.00476/full |
| _version_ | 1818965686522740736 |
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| author | Keizo Kanasaki Keizo Kanasaki Emi Kawakita Daisuke Koya Daisuke Koya |
| author_facet | Keizo Kanasaki Keizo Kanasaki Emi Kawakita Daisuke Koya Daisuke Koya |
| author_sort | Keizo Kanasaki |
| collection | DOAJ |
| description | The biology of autophagy in health and disease conditions has been intensively analyzed for decades. Several potential interventions can induce autophagy in preclinical research; however, none of these interventions are ready for translation to clinical practice yet. The topic of the current review is the molecular regulation of autophagy by glucagon, glucagon-like peptide (GLP)-1 and the GLP-1-degrading enzyme dipeptidyl peptidase-4 (DPP-4). Glucagon is a well-known polypeptide that induces autophagy. In contrast, GLP-1 has been shown to inhibit glucagon secretion; GLP-1 also has been related to the induction of autophagy. DPP-4 inhibitors can induce autophagy in a GLP-1–dependent manner, but other diverse effects could be relevant. Here, we analyze the distinct molecular regulation of autophagy by glucagon, GLP-1, and DPP-4 inhibitors. Additionally, the potential contribution to autophagy by glucagon and GLP-1 after bariatric surgery is discussed. |
| first_indexed | 2024-12-20T13:20:57Z |
| format | Article |
| id | doaj.art-706fa4927237441ca70e92002298faef |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-20T13:20:57Z |
| publishDate | 2019-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-706fa4927237441ca70e92002298faef2022-12-21T19:39:24ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122019-05-011010.3389/fphar.2019.00476448632Relevance of Autophagy Induction by Gastrointestinal Hormones: Focus on the Incretin-Based Drug Target and GlucagonKeizo Kanasaki0Keizo Kanasaki1Emi Kawakita2Daisuke Koya3Daisuke Koya4Department of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, JapanDivision of Anticipatory Molecular Food Science and Technology, Medical Research Institute, Kanazawa Medical University, Uchinada, JapanDepartment of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, JapanDepartment of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, JapanDivision of Anticipatory Molecular Food Science and Technology, Medical Research Institute, Kanazawa Medical University, Uchinada, JapanThe biology of autophagy in health and disease conditions has been intensively analyzed for decades. Several potential interventions can induce autophagy in preclinical research; however, none of these interventions are ready for translation to clinical practice yet. The topic of the current review is the molecular regulation of autophagy by glucagon, glucagon-like peptide (GLP)-1 and the GLP-1-degrading enzyme dipeptidyl peptidase-4 (DPP-4). Glucagon is a well-known polypeptide that induces autophagy. In contrast, GLP-1 has been shown to inhibit glucagon secretion; GLP-1 also has been related to the induction of autophagy. DPP-4 inhibitors can induce autophagy in a GLP-1–dependent manner, but other diverse effects could be relevant. Here, we analyze the distinct molecular regulation of autophagy by glucagon, GLP-1, and DPP-4 inhibitors. Additionally, the potential contribution to autophagy by glucagon and GLP-1 after bariatric surgery is discussed.https://www.frontiersin.org/article/10.3389/fphar.2019.00476/fullautophagyincretinGLP-1DPP-4glucagon |
| spellingShingle | Keizo Kanasaki Keizo Kanasaki Emi Kawakita Daisuke Koya Daisuke Koya Relevance of Autophagy Induction by Gastrointestinal Hormones: Focus on the Incretin-Based Drug Target and Glucagon Frontiers in Pharmacology autophagy incretin GLP-1 DPP-4 glucagon |
| title | Relevance of Autophagy Induction by Gastrointestinal Hormones: Focus on the Incretin-Based Drug Target and Glucagon |
| title_full | Relevance of Autophagy Induction by Gastrointestinal Hormones: Focus on the Incretin-Based Drug Target and Glucagon |
| title_fullStr | Relevance of Autophagy Induction by Gastrointestinal Hormones: Focus on the Incretin-Based Drug Target and Glucagon |
| title_full_unstemmed | Relevance of Autophagy Induction by Gastrointestinal Hormones: Focus on the Incretin-Based Drug Target and Glucagon |
| title_short | Relevance of Autophagy Induction by Gastrointestinal Hormones: Focus on the Incretin-Based Drug Target and Glucagon |
| title_sort | relevance of autophagy induction by gastrointestinal hormones focus on the incretin based drug target and glucagon |
| topic | autophagy incretin GLP-1 DPP-4 glucagon |
| url | https://www.frontiersin.org/article/10.3389/fphar.2019.00476/full |
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