Do cerebral microbleeds increase the risk of dementia? A systematic review and meta-analysis
Background: Dementia is a neurological disorder that commonly affects the elderly. Cerebral microbleeds (CMBs) are small, tiny lesions of the cerebral blood vessels and have been suggested as a possible risk factor for dementia. However, data about the association between CMBs and dementia risk are...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | IBRO Neuroscience Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242122001051 |
| _version_ | 1827926400197197824 |
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| author | Ahmed Salah Hussein Muhammad Shawqi Eshak I. Bahbah Basma Ragab Mohammad Sunoqrot Ahmed Gadallah Hazem S. Ghaith Ahmed Negida |
| author_facet | Ahmed Salah Hussein Muhammad Shawqi Eshak I. Bahbah Basma Ragab Mohammad Sunoqrot Ahmed Gadallah Hazem S. Ghaith Ahmed Negida |
| author_sort | Ahmed Salah Hussein |
| collection | DOAJ |
| description | Background: Dementia is a neurological disorder that commonly affects the elderly. Cerebral microbleeds (CMBs) are small, tiny lesions of the cerebral blood vessels and have been suggested as a possible risk factor for dementia. However, data about the association between CMBs and dementia risk are inconsistent and inconclusive. Therefore, we conducted this systematic review and meta-analysis to investigate the association between CMBs and dementia and highlight the possible explanations. Methods: We followed the standard PRISMA statement and the Cochrane Handbook guidelines to conduct this study. First, we searched medical electronic databases for relevant articles. Then, we screened the retrieved articles for eligibility, extracted the relevant data, and appraised the methodological quality using the Newcastle-Ottawa Scale. Finally, the extracted data were pooled as risk ratios (RR) and hazard ratios (HR) in the random-effects meta-analysis model using the Review Manager software. Results: We included nine studies with 14,221 participants and follow-up periods > 18 months. Overall, CMBs significantly increased the risk of developing dementia (RR 1.84, 95% CI [1.27–2.65]). This association was significant in the subgroups of studies on high-risk populations (RR 2.00, 95% CI [1.41–2.83], n = 1657 participants) and those in the general population (RR 2.30, 95% CI [1.25–4.26], n = 12,087 participants) but not in the memory clinic patients. Further, CMBs increased the risk of progressing to incident dementia over time (HR 2, 95% CI [1.54–2.61]). Conclusion: Individuals with CMBs have twice the risk of developing dementia or progressing to MCI than those without CMBs. The detection of CMBs will help identify the population at higher risk of developing dementia. Physicians should educate individuals with CMBs and their families on the possibility of progressing to dementia or MCI. Regular cognitive assessments, cognitive training, lifestyle modifications, and controlling other dementia risk factors are recommended for individuals with CMBs to decrease the risk of cognitive decline and dementia development. |
| first_indexed | 2024-03-13T05:38:37Z |
| format | Article |
| id | doaj.art-706ff01d2bac4483ae09a483e3779e23 |
| institution | Directory Open Access Journal |
| issn | 2667-2421 |
| language | English |
| last_indexed | 2024-03-13T05:38:37Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj.art-706ff01d2bac4483ae09a483e3779e232023-06-14T04:34:37ZengElsevierIBRO Neuroscience Reports2667-24212023-06-01148694Do cerebral microbleeds increase the risk of dementia? A systematic review and meta-analysisAhmed Salah Hussein0Muhammad Shawqi1Eshak I. Bahbah2Basma Ragab3Mohammad Sunoqrot4Ahmed Gadallah5Hazem S. Ghaith6Ahmed Negida7Medical Research Group of Egypt (MRGE), Cairo, Egypt; Faculty of Medicine, Al-Azhar University, Cairo, EgyptMedical Research Group of Egypt (MRGE), Cairo, Egypt; Faculty of Medicine, Assiut University, Assiut, EgyptMedical Research Group of Egypt (MRGE), Cairo, Egypt; Faculty of Medicine, Al-Azhar University, Damietta, EgyptMedical Research Group of Egypt (MRGE), Cairo, Egypt; Faculty of Physical Therapy, Cairo University, Cairo, EgyptMedical Research Group of Egypt (MRGE), Cairo, Egypt; Faculty of Medicine, Cairo University, Cairo, EgyptMedical Research Group of Egypt (MRGE), Cairo, Egypt; Ain Shams University Hospitals, Cairo, EgyptMedical Research Group of Egypt (MRGE), Cairo, Egypt; Faculty of Medicine, Al-Azhar University, Cairo, EgyptMedical Research Group of Egypt (MRGE), Cairo, Egypt; Faculty of Medicine, Zagazig University, Egypt; School of Pharmacy and Biomedical Sciences, University of Portsmouth, United Kingdom; Department of Global Health and Social Medicine, Harvard Medical School, MA, USA; Correspondence to: Harvard Medical School, 641 Huntington Avenue, Boston, MA 02115, USA.Background: Dementia is a neurological disorder that commonly affects the elderly. Cerebral microbleeds (CMBs) are small, tiny lesions of the cerebral blood vessels and have been suggested as a possible risk factor for dementia. However, data about the association between CMBs and dementia risk are inconsistent and inconclusive. Therefore, we conducted this systematic review and meta-analysis to investigate the association between CMBs and dementia and highlight the possible explanations. Methods: We followed the standard PRISMA statement and the Cochrane Handbook guidelines to conduct this study. First, we searched medical electronic databases for relevant articles. Then, we screened the retrieved articles for eligibility, extracted the relevant data, and appraised the methodological quality using the Newcastle-Ottawa Scale. Finally, the extracted data were pooled as risk ratios (RR) and hazard ratios (HR) in the random-effects meta-analysis model using the Review Manager software. Results: We included nine studies with 14,221 participants and follow-up periods > 18 months. Overall, CMBs significantly increased the risk of developing dementia (RR 1.84, 95% CI [1.27–2.65]). This association was significant in the subgroups of studies on high-risk populations (RR 2.00, 95% CI [1.41–2.83], n = 1657 participants) and those in the general population (RR 2.30, 95% CI [1.25–4.26], n = 12,087 participants) but not in the memory clinic patients. Further, CMBs increased the risk of progressing to incident dementia over time (HR 2, 95% CI [1.54–2.61]). Conclusion: Individuals with CMBs have twice the risk of developing dementia or progressing to MCI than those without CMBs. The detection of CMBs will help identify the population at higher risk of developing dementia. Physicians should educate individuals with CMBs and their families on the possibility of progressing to dementia or MCI. Regular cognitive assessments, cognitive training, lifestyle modifications, and controlling other dementia risk factors are recommended for individuals with CMBs to decrease the risk of cognitive decline and dementia development.http://www.sciencedirect.com/science/article/pii/S2667242122001051Brain microbleedsCerebral microbleedsCognitive declineDementia |
| spellingShingle | Ahmed Salah Hussein Muhammad Shawqi Eshak I. Bahbah Basma Ragab Mohammad Sunoqrot Ahmed Gadallah Hazem S. Ghaith Ahmed Negida Do cerebral microbleeds increase the risk of dementia? A systematic review and meta-analysis IBRO Neuroscience Reports Brain microbleeds Cerebral microbleeds Cognitive decline Dementia |
| title | Do cerebral microbleeds increase the risk of dementia? A systematic review and meta-analysis |
| title_full | Do cerebral microbleeds increase the risk of dementia? A systematic review and meta-analysis |
| title_fullStr | Do cerebral microbleeds increase the risk of dementia? A systematic review and meta-analysis |
| title_full_unstemmed | Do cerebral microbleeds increase the risk of dementia? A systematic review and meta-analysis |
| title_short | Do cerebral microbleeds increase the risk of dementia? A systematic review and meta-analysis |
| title_sort | do cerebral microbleeds increase the risk of dementia a systematic review and meta analysis |
| topic | Brain microbleeds Cerebral microbleeds Cognitive decline Dementia |
| url | http://www.sciencedirect.com/science/article/pii/S2667242122001051 |
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