A magnetophoretic microdevice for multi-magnetic particles separation based on size: a numerical simulation study
Due to the outstanding properties, magnetic particles have been widely used as magnetic carriers and adsorbents in a diverse range of fields, such as biomedical diagnostics, food safety, and environmental monitoring, etc. Sorting different magnetic particles from each other based on size simultaneou...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Engineering Applications of Computational Fluid Mechanics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19942060.2022.2109064 |
| _version_ | 1811274280821850112 |
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| author | Jia Ruan Weiwei Zhang Chi Zhang Na Li Jian Jiang Huilan Su |
| author_facet | Jia Ruan Weiwei Zhang Chi Zhang Na Li Jian Jiang Huilan Su |
| author_sort | Jia Ruan |
| collection | DOAJ |
| description | Due to the outstanding properties, magnetic particles have been widely used as magnetic carriers and adsorbents in a diverse range of fields, such as biomedical diagnostics, food safety, and environmental monitoring, etc. Sorting different magnetic particles from each other based on size simultaneously can be very useful in multiple targets separation. To the best of our knowledge, this research firstly proposes the arc comb structure microfluidic (ACSM) chip for multi-magnetic particles separation based on size by magnetophoresis. And the parameters affecting particle trajectory and separation efficiencies, such as flow velocity, velocity ratio of the two inlets, the remanent flux density of the magnets, and dynamic viscosity of the buffer solution, were investigated by numerical simulations in this study. Particle magnetophoresis spectrum width [Formula: see text] and general separation ratio [Formula: see text] are put forward to characterize the particles separation efficiency. Under the recommended simulation condition, six kinds of magnetic beads were separated with a general separation ratio [Formula: see text] of 0.83 using the newly designed chip. And the separation ratio [Formula: see text] of the 0.5, 1.8, 2.5, 3, 3.5 and 4.5 µm magnetic particle is 100.00%, 98.18%, 66.36%, 97.25%, 97.27% and 96.36%, respectively. This numerical simulation study provides a theoretical basis for multiple magnetic particles’ separation before experimental trials and also facilitates the utilization and development of microfluidic chips in the future. |
| first_indexed | 2024-04-12T23:16:11Z |
| format | Article |
| id | doaj.art-70715c004be44aa88b439c0e904413eb |
| institution | Directory Open Access Journal |
| issn | 1994-2060 1997-003X |
| language | English |
| last_indexed | 2024-04-12T23:16:11Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Engineering Applications of Computational Fluid Mechanics |
| spelling | doaj.art-70715c004be44aa88b439c0e904413eb2022-12-22T03:12:40ZengTaylor & Francis GroupEngineering Applications of Computational Fluid Mechanics1994-20601997-003X2022-12-011611781179510.1080/19942060.2022.2109064A magnetophoretic microdevice for multi-magnetic particles separation based on size: a numerical simulation studyJia Ruan0Weiwei Zhang1Chi Zhang2Na Li3Jian Jiang4Huilan Su5Department of Public Health, Chengdu Medical College, Chengdu, People’s Republic of ChinaDepartment of Public Health, Chengdu Medical College, Chengdu, People’s Republic of ChinaDepartment of Public Health, Chengdu Medical College, Chengdu, People’s Republic of ChinaDepartment of Public Health, Chengdu Medical College, Chengdu, People’s Republic of ChinaYibin Municipal Center for Disease Control and Prevention, Yibin, People’s Republic of ChinaDepartment of Public Health, Chengdu Medical College, Chengdu, People’s Republic of ChinaDue to the outstanding properties, magnetic particles have been widely used as magnetic carriers and adsorbents in a diverse range of fields, such as biomedical diagnostics, food safety, and environmental monitoring, etc. Sorting different magnetic particles from each other based on size simultaneously can be very useful in multiple targets separation. To the best of our knowledge, this research firstly proposes the arc comb structure microfluidic (ACSM) chip for multi-magnetic particles separation based on size by magnetophoresis. And the parameters affecting particle trajectory and separation efficiencies, such as flow velocity, velocity ratio of the two inlets, the remanent flux density of the magnets, and dynamic viscosity of the buffer solution, were investigated by numerical simulations in this study. Particle magnetophoresis spectrum width [Formula: see text] and general separation ratio [Formula: see text] are put forward to characterize the particles separation efficiency. Under the recommended simulation condition, six kinds of magnetic beads were separated with a general separation ratio [Formula: see text] of 0.83 using the newly designed chip. And the separation ratio [Formula: see text] of the 0.5, 1.8, 2.5, 3, 3.5 and 4.5 µm magnetic particle is 100.00%, 98.18%, 66.36%, 97.25%, 97.27% and 96.36%, respectively. This numerical simulation study provides a theoretical basis for multiple magnetic particles’ separation before experimental trials and also facilitates the utilization and development of microfluidic chips in the future.https://www.tandfonline.com/doi/10.1080/19942060.2022.2109064arc comb structure microfluidic chipmagnetophoresissize-selective separationnumerical simulation study |
| spellingShingle | Jia Ruan Weiwei Zhang Chi Zhang Na Li Jian Jiang Huilan Su A magnetophoretic microdevice for multi-magnetic particles separation based on size: a numerical simulation study Engineering Applications of Computational Fluid Mechanics arc comb structure microfluidic chip magnetophoresis size-selective separation numerical simulation study |
| title | A magnetophoretic microdevice for multi-magnetic particles separation based on size: a numerical simulation study |
| title_full | A magnetophoretic microdevice for multi-magnetic particles separation based on size: a numerical simulation study |
| title_fullStr | A magnetophoretic microdevice for multi-magnetic particles separation based on size: a numerical simulation study |
| title_full_unstemmed | A magnetophoretic microdevice for multi-magnetic particles separation based on size: a numerical simulation study |
| title_short | A magnetophoretic microdevice for multi-magnetic particles separation based on size: a numerical simulation study |
| title_sort | magnetophoretic microdevice for multi magnetic particles separation based on size a numerical simulation study |
| topic | arc comb structure microfluidic chip magnetophoresis size-selective separation numerical simulation study |
| url | https://www.tandfonline.com/doi/10.1080/19942060.2022.2109064 |
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