Assessment of pharmacological strategies for management of major depressive disorder and their costs after an inadequate response to first-line antidepressant treatment in primary care
<p>Abstract</p> <p>Background</p> <p>The aim of the study was to determine the most common treatment strategies and their costs for patients with an inadequate response to first-line antidepressant treatment (AD) in primary care.</p> <p>Method</p> <...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-08-01
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| Series: | Annals of General Psychiatry |
| Subjects: | |
| Online Access: | http://www.annals-general-psychiatry.com/content/11/1/22 |
| _version_ | 1818806462396235776 |
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| author | Sicras-Mainar Antoni Maurino Jorge Cordero Luis Blanca-Tamayo Milagrosa Navarro-Artieda Ruth |
| author_facet | Sicras-Mainar Antoni Maurino Jorge Cordero Luis Blanca-Tamayo Milagrosa Navarro-Artieda Ruth |
| author_sort | Sicras-Mainar Antoni |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The aim of the study was to determine the most common treatment strategies and their costs for patients with an inadequate response to first-line antidepressant treatment (AD) in primary care.</p> <p>Method</p> <p>A retrospective cohort study of medical records from six primary care centers was conducted. Adults with a major depressive disorder diagnosis, at least 8 weeks of AD treatment after the first prescription, and patient monitoring for 12 months were analyzed. Healthcare (direct cost) and non-healthcare costs (indirect costs; work productivity losses) were described.</p> <p>Results</p> <p>A total of 2,260 patients were studied. Forty-three percent of patients (N = 965) presented an inadequate response to treatment. Summarizing the different treatment approaches: 43.2% were switched to another AD, 15.5% were given an additional AD, AD dose was increased in 14.6%, and 26.7% remained with the same antidepressant agent. Healthcare/annual costs were 451.2 Euros for patients in remission vs. 826.1 Euros in those with inadequate response, and productivity losses were 991.4 versus 1,842.0 Euros, respectively (p < 0.001).</p> <p>Conclusion</p> <p>Antidepressant switch was the most common therapeutic approach performed by general practitioners in naturalistic practice. A delay in treatment change when no remission occurs and a significant heterogeneity in management of these patients were also found.</p> |
| first_indexed | 2024-12-18T19:10:09Z |
| format | Article |
| id | doaj.art-707180f2879345f1b632a00cceae1b85 |
| institution | Directory Open Access Journal |
| issn | 1744-859X |
| language | English |
| last_indexed | 2024-12-18T19:10:09Z |
| publishDate | 2012-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Annals of General Psychiatry |
| spelling | doaj.art-707180f2879345f1b632a00cceae1b852022-12-21T20:56:17ZengBMCAnnals of General Psychiatry1744-859X2012-08-011112210.1186/1744-859X-11-22Assessment of pharmacological strategies for management of major depressive disorder and their costs after an inadequate response to first-line antidepressant treatment in primary careSicras-Mainar AntoniMaurino JorgeCordero LuisBlanca-Tamayo MilagrosaNavarro-Artieda Ruth<p>Abstract</p> <p>Background</p> <p>The aim of the study was to determine the most common treatment strategies and their costs for patients with an inadequate response to first-line antidepressant treatment (AD) in primary care.</p> <p>Method</p> <p>A retrospective cohort study of medical records from six primary care centers was conducted. Adults with a major depressive disorder diagnosis, at least 8 weeks of AD treatment after the first prescription, and patient monitoring for 12 months were analyzed. Healthcare (direct cost) and non-healthcare costs (indirect costs; work productivity losses) were described.</p> <p>Results</p> <p>A total of 2,260 patients were studied. Forty-three percent of patients (N = 965) presented an inadequate response to treatment. Summarizing the different treatment approaches: 43.2% were switched to another AD, 15.5% were given an additional AD, AD dose was increased in 14.6%, and 26.7% remained with the same antidepressant agent. Healthcare/annual costs were 451.2 Euros for patients in remission vs. 826.1 Euros in those with inadequate response, and productivity losses were 991.4 versus 1,842.0 Euros, respectively (p < 0.001).</p> <p>Conclusion</p> <p>Antidepressant switch was the most common therapeutic approach performed by general practitioners in naturalistic practice. A delay in treatment change when no remission occurs and a significant heterogeneity in management of these patients were also found.</p>http://www.annals-general-psychiatry.com/content/11/1/22Major depressive disorderRemissionPrimary careFirst-line antidepressant treatmentCosts |
| spellingShingle | Sicras-Mainar Antoni Maurino Jorge Cordero Luis Blanca-Tamayo Milagrosa Navarro-Artieda Ruth Assessment of pharmacological strategies for management of major depressive disorder and their costs after an inadequate response to first-line antidepressant treatment in primary care Annals of General Psychiatry Major depressive disorder Remission Primary care First-line antidepressant treatment Costs |
| title | Assessment of pharmacological strategies for management of major depressive disorder and their costs after an inadequate response to first-line antidepressant treatment in primary care |
| title_full | Assessment of pharmacological strategies for management of major depressive disorder and their costs after an inadequate response to first-line antidepressant treatment in primary care |
| title_fullStr | Assessment of pharmacological strategies for management of major depressive disorder and their costs after an inadequate response to first-line antidepressant treatment in primary care |
| title_full_unstemmed | Assessment of pharmacological strategies for management of major depressive disorder and their costs after an inadequate response to first-line antidepressant treatment in primary care |
| title_short | Assessment of pharmacological strategies for management of major depressive disorder and their costs after an inadequate response to first-line antidepressant treatment in primary care |
| title_sort | assessment of pharmacological strategies for management of major depressive disorder and their costs after an inadequate response to first line antidepressant treatment in primary care |
| topic | Major depressive disorder Remission Primary care First-line antidepressant treatment Costs |
| url | http://www.annals-general-psychiatry.com/content/11/1/22 |
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