The Role of Interleukine-33 in Inflammatory Bowel Disease
The inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) are heterogenous chronic inflammatory disorders of the gastrointestinal tract. The most widely accepted etiopathogenic hypothesis for these disorders suggests an immune mediated process. Objective: This study was...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Baghdad/ Al-Kindy College of Medicine
2014-06-01
|
| Series: | مجله كليه طب الكندي |
| Subjects: | |
| Online Access: | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/439 |
| _version_ | 1818480944726671360 |
|---|---|
| author | Raghad R. Hwyidii Ahmed A. Abbas Khalid A. AL-Khazraji |
| author_facet | Raghad R. Hwyidii Ahmed A. Abbas Khalid A. AL-Khazraji |
| author_sort | Raghad R. Hwyidii |
| collection | DOAJ |
| description |
The inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) are heterogenous chronic inflammatory disorders of the gastrointestinal tract. The most widely accepted etiopathogenic hypothesis for these disorders suggests an immune mediated process.
Objective: This study was performed to evaluate the role of interleukine-33 in pathogenesis of inflammatory bowel disease and to correlate their levels with the disease activity and/or severity.
Methods: Fifty five subjects with inflammatory bowel disease (41 ulcerative colitis patients and 14 Crohn’s disease patients) their ages range from 16-65 years and 25 apparently healthy volunteers their ages and sexes were matched with the patients were participated in this study. Blood samples were collected from all patients and controls to assess serum concentrations of interleukine-33 by enzyme-linked immune-sorbent assay.
Results: The present data revealed that there was significant elevation (P<0.05) in serum levels of interleukine-33 in ulcerative colitis and Crohn’s disease patients as compared with control group. Concerning the correlation between serum levels of interleukine-33 with clinical parameters, the current study revealed a positive correlation between serum interleukine -33 with the disease activity in ulcerative colitis (P=0.41). As regards to disease location, interleukine-33 was significantly higher (P<0.001) in ulcerative colitis patients with pan-colitis (E3) as compared to those patients with proctitis disease (E1) and CD of the colon (E2).
Conclusion: This study indicated that interleukine-33 might be a crucial mediator in the pathogenesis of inflammatory bowel disease.
|
| first_indexed | 2024-12-10T11:28:47Z |
| format | Article |
| id | doaj.art-7071e82e70904bcca3121a0bc4cbd966 |
| institution | Directory Open Access Journal |
| issn | 1810-9543 2521-4365 |
| language | English |
| last_indexed | 2024-12-10T11:28:47Z |
| publishDate | 2014-06-01 |
| publisher | University of Baghdad/ Al-Kindy College of Medicine |
| record_format | Article |
| series | مجله كليه طب الكندي |
| spelling | doaj.art-7071e82e70904bcca3121a0bc4cbd9662022-12-22T01:50:40ZengUniversity of Baghdad/ Al-Kindy College of Medicineمجله كليه طب الكندي1810-95432521-43652014-06-01102The Role of Interleukine-33 in Inflammatory Bowel DiseaseRaghad R. Hwyidii0Ahmed A. Abbas1Khalid A. AL-Khazraji2Department of Microbiology, Medical College ,AL-Nahrain University-IraqDepartment of Microbiology,Medical College, Al-Nahrain University- IraqMedical Collage, Baghdad University-Iraq The inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) are heterogenous chronic inflammatory disorders of the gastrointestinal tract. The most widely accepted etiopathogenic hypothesis for these disorders suggests an immune mediated process. Objective: This study was performed to evaluate the role of interleukine-33 in pathogenesis of inflammatory bowel disease and to correlate their levels with the disease activity and/or severity. Methods: Fifty five subjects with inflammatory bowel disease (41 ulcerative colitis patients and 14 Crohn’s disease patients) their ages range from 16-65 years and 25 apparently healthy volunteers their ages and sexes were matched with the patients were participated in this study. Blood samples were collected from all patients and controls to assess serum concentrations of interleukine-33 by enzyme-linked immune-sorbent assay. Results: The present data revealed that there was significant elevation (P<0.05) in serum levels of interleukine-33 in ulcerative colitis and Crohn’s disease patients as compared with control group. Concerning the correlation between serum levels of interleukine-33 with clinical parameters, the current study revealed a positive correlation between serum interleukine -33 with the disease activity in ulcerative colitis (P=0.41). As regards to disease location, interleukine-33 was significantly higher (P<0.001) in ulcerative colitis patients with pan-colitis (E3) as compared to those patients with proctitis disease (E1) and CD of the colon (E2). Conclusion: This study indicated that interleukine-33 might be a crucial mediator in the pathogenesis of inflammatory bowel disease. https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/439Inflammatory bowel disease,IL-33Ulcerative colitis. |
| spellingShingle | Raghad R. Hwyidii Ahmed A. Abbas Khalid A. AL-Khazraji The Role of Interleukine-33 in Inflammatory Bowel Disease مجله كليه طب الكندي Inflammatory bowel disease, IL-33 Ulcerative colitis. |
| title | The Role of Interleukine-33 in Inflammatory Bowel Disease |
| title_full | The Role of Interleukine-33 in Inflammatory Bowel Disease |
| title_fullStr | The Role of Interleukine-33 in Inflammatory Bowel Disease |
| title_full_unstemmed | The Role of Interleukine-33 in Inflammatory Bowel Disease |
| title_short | The Role of Interleukine-33 in Inflammatory Bowel Disease |
| title_sort | role of interleukine 33 in inflammatory bowel disease |
| topic | Inflammatory bowel disease, IL-33 Ulcerative colitis. |
| url | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/439 |
| work_keys_str_mv | AT raghadrhwyidii theroleofinterleukine33ininflammatoryboweldisease AT ahmedaabbas theroleofinterleukine33ininflammatoryboweldisease AT khalidaalkhazraji theroleofinterleukine33ininflammatoryboweldisease AT raghadrhwyidii roleofinterleukine33ininflammatoryboweldisease AT ahmedaabbas roleofinterleukine33ininflammatoryboweldisease AT khalidaalkhazraji roleofinterleukine33ininflammatoryboweldisease |