Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice
Chronic use of mTORC1 inhibitors produces undesirable side effects in humans which limit their value for CNS disorders treatment. The authors present a binary drug strategy to protects mTORC1 activity in the periphery and show its potential utility in preclinical models of alcohol use disorder.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24567-x |
| _version_ | 1819126267266465792 |
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| author | Yann Ehinger Ziyang Zhang Khanhky Phamluong Drishti Soneja Kevan M. Shokat Dorit Ron |
| author_facet | Yann Ehinger Ziyang Zhang Khanhky Phamluong Drishti Soneja Kevan M. Shokat Dorit Ron |
| author_sort | Yann Ehinger |
| collection | DOAJ |
| description | Chronic use of mTORC1 inhibitors produces undesirable side effects in humans which limit their value for CNS disorders treatment. The authors present a binary drug strategy to protects mTORC1 activity in the periphery and show its potential utility in preclinical models of alcohol use disorder. |
| first_indexed | 2024-12-22T07:53:19Z |
| format | Article |
| id | doaj.art-7072a98d7a1d453daff66668b3c58af7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T07:53:19Z |
| publishDate | 2021-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7072a98d7a1d453daff66668b3c58af72022-12-21T18:33:25ZengNature PortfolioNature Communications2041-17232021-07-0112111110.1038/s41467-021-24567-xBrain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in miceYann Ehinger0Ziyang Zhang1Khanhky Phamluong2Drishti Soneja3Kevan M. Shokat4Dorit Ron5Department of Neurology, University of California San FranciscoDepartment of Cellular and Molecular Pharmacology and Howard Hughes Medical Institute, University of CaliforniaDepartment of Neurology, University of California San FranciscoDepartment of Neurology, University of California San FranciscoDepartment of Cellular and Molecular Pharmacology and Howard Hughes Medical Institute, University of CaliforniaDepartment of Neurology, University of California San FranciscoChronic use of mTORC1 inhibitors produces undesirable side effects in humans which limit their value for CNS disorders treatment. The authors present a binary drug strategy to protects mTORC1 activity in the periphery and show its potential utility in preclinical models of alcohol use disorder.https://doi.org/10.1038/s41467-021-24567-x |
| spellingShingle | Yann Ehinger Ziyang Zhang Khanhky Phamluong Drishti Soneja Kevan M. Shokat Dorit Ron Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice Nature Communications |
| title | Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice |
| title_full | Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice |
| title_fullStr | Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice |
| title_full_unstemmed | Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice |
| title_short | Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice |
| title_sort | brain specific inhibition of mtorc1 eliminates side effects resulting from mtorc1 blockade in the periphery and reduces alcohol intake in mice |
| url | https://doi.org/10.1038/s41467-021-24567-x |
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