Controlling cisplatin release by synergistic action of silver-cisplatin on monodispersed spherical silica for targeted anticancer and antibacterial activities
Recently, metal-based nanoformulations have been explored for targeted cancer therapeutics. In this study, synergistic therapeutic action of silver (Ag)-cisplatin nanoparticles loaded on monodispersed spherical silica (MSS) was investigated to evaluate anti-cancer (HCT-116 and HeLa cells) and antiba...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535224000637 |
| _version_ | 1797248348426600448 |
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| author | Suriya Rehman Vijaya Ravinayagam Suhailah S. Al-Jameel Syed Mehmood Ali Sukainah Z. Alzayer Zahrah M. Alfaraj Atheer Alboeid Nawal Alamri Sakinah H Al Isam H. Dafallae Sugapriya Dhanasekaran Gazali Tanimu Firdos Alam Khan B. Rabindran Jermy |
| author_facet | Suriya Rehman Vijaya Ravinayagam Suhailah S. Al-Jameel Syed Mehmood Ali Sukainah Z. Alzayer Zahrah M. Alfaraj Atheer Alboeid Nawal Alamri Sakinah H Al Isam H. Dafallae Sugapriya Dhanasekaran Gazali Tanimu Firdos Alam Khan B. Rabindran Jermy |
| author_sort | Suriya Rehman |
| collection | DOAJ |
| description | Recently, metal-based nanoformulations have been explored for targeted cancer therapeutics. In this study, synergistic therapeutic action of silver (Ag)-cisplatin nanoparticles loaded on monodispersed spherical silica (MSS) was investigated to evaluate anti-cancer (HCT-116 and HeLa cells) and antibacterial activity (P.aeruginosa, and S.aureus). Four different wt% of Ag (1, 2, 4 and 6 wt%) was loaded on MSS using a wet impregnation method. Characterization using XRD revealed the cubic phase of Ag nanoparticles with (111), (200) and (220) plane on MSS. The chemical state, dispersion of Ag and synergistic cohabitation with cisplatin (Cpt) was identified using diffuse reflectance UV–visible spectroscopy (DR-UV Vis), X-ray photoelectron spectroscopy (XPS), Scanning electron microscopy/energy-dispersive X-ray spectrometry (SEM-EDS) and High-resolution transmission electron microscopy (HR-TEM). Zeta potential analysis indicated an increase in hydrodynamic diameter with high colloidal stability (–23.3 to −28.5 mV). The percentage cumulative Cpt release was studied using automated Franz cell and dialysis membrane technique. The effect of Cpt release on 4 wt%Ag impregnated on different shaped supports was investigated using cubic SBA-16 (Santa Barbara Amorphous), MFI type Ti-ZSM-5 (Zeolite Socony Mobil #5), hexagonal mesosilicalite, nanotube halloysite, and Ag-silicalite, respectively. Drug release study indicates that Ag loading controls the Cpt release. The kinetics of drug release for the different formulations was examined using Korsmeyers-Peppas model. Release constant (k) and release exponent (n) were utilized for the rate of drug release and diffusion mechanisms, respectively. The in vitro study revealed an efficient interaction of nanoformulations promoting both antibacterial and anticancer activities. |
| first_indexed | 2024-03-08T00:50:01Z |
| format | Article |
| id | doaj.art-7072cfc6dba64c31809f0c2e8337f2dd |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-04-24T20:13:10Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-7072cfc6dba64c31809f0c2e8337f2dd2024-03-23T06:23:35ZengElsevierArabian Journal of Chemistry1878-53522024-04-01174105661Controlling cisplatin release by synergistic action of silver-cisplatin on monodispersed spherical silica for targeted anticancer and antibacterial activitiesSuriya Rehman0Vijaya Ravinayagam1Suhailah S. Al-Jameel2Syed Mehmood Ali3Sukainah Z. Alzayer4Zahrah M. Alfaraj5Atheer Alboeid6Nawal Alamri7Sakinah H Al Isam8H. Dafallae9Sugapriya Dhanasekaran10Gazali Tanimu11Firdos Alam Khan12B. Rabindran Jermy13Department of Epidemic Diseases Research, Institute for Research & Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi ArabiaDeanship of Scientific Research & Department of NanoMedicine Research, Institute for Research & Medical Consultations, Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi Arabia; Corresponding authors.Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi ArabiaDepartment of Biomedical Engineering, College of Engineering, Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi ArabiaIRMC-InP-2021 Program, Department of Epidemic Diseases Research & Department of Nano-Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi Arabia; College of Dentistry, Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi ArabiaIRMC-InP-2021 Program, Department of Epidemic Diseases Research & Department of Nano-Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi Arabia; College of Dentistry, Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi ArabiaIRMC-InP-2021 Program, Department of Epidemic Diseases Research & Department of Nano-Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi Arabia; College of Dentistry, Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi ArabiaIRMC-InP-2021 Program, Department of Epidemic Diseases Research & Department of Nano-Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi Arabia; College of Dentistry, Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi ArabiaIRMC-InP-2021 Program, Department of Epidemic Diseases Research & Department of Nano-Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi Arabia; College of Dentistry, Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi ArabiaCollege of Engineering Research (CER), King Fahd University of Petroleum and Minerals, 31261 Dhahran, Saudi ArabiaDepartment of Medical Lab Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Wadi Ad Dawasir Campus, Saudi ArabiaCenter for Refining and Advanced Chemicals, Research Institute, King Fahd University of Petroleum and Minerals, P.O. Box 5040, Dhahran 31261, Saudi ArabiaDepartment of Stem Cell Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi ArabiaDepartment of NanoMedicine Research, Institute for Research & Medical Consultations, Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi Arabia; Corresponding authors.Recently, metal-based nanoformulations have been explored for targeted cancer therapeutics. In this study, synergistic therapeutic action of silver (Ag)-cisplatin nanoparticles loaded on monodispersed spherical silica (MSS) was investigated to evaluate anti-cancer (HCT-116 and HeLa cells) and antibacterial activity (P.aeruginosa, and S.aureus). Four different wt% of Ag (1, 2, 4 and 6 wt%) was loaded on MSS using a wet impregnation method. Characterization using XRD revealed the cubic phase of Ag nanoparticles with (111), (200) and (220) plane on MSS. The chemical state, dispersion of Ag and synergistic cohabitation with cisplatin (Cpt) was identified using diffuse reflectance UV–visible spectroscopy (DR-UV Vis), X-ray photoelectron spectroscopy (XPS), Scanning electron microscopy/energy-dispersive X-ray spectrometry (SEM-EDS) and High-resolution transmission electron microscopy (HR-TEM). Zeta potential analysis indicated an increase in hydrodynamic diameter with high colloidal stability (–23.3 to −28.5 mV). The percentage cumulative Cpt release was studied using automated Franz cell and dialysis membrane technique. The effect of Cpt release on 4 wt%Ag impregnated on different shaped supports was investigated using cubic SBA-16 (Santa Barbara Amorphous), MFI type Ti-ZSM-5 (Zeolite Socony Mobil #5), hexagonal mesosilicalite, nanotube halloysite, and Ag-silicalite, respectively. Drug release study indicates that Ag loading controls the Cpt release. The kinetics of drug release for the different formulations was examined using Korsmeyers-Peppas model. Release constant (k) and release exponent (n) were utilized for the rate of drug release and diffusion mechanisms, respectively. The in vitro study revealed an efficient interaction of nanoformulations promoting both antibacterial and anticancer activities.http://www.sciencedirect.com/science/article/pii/S1878535224000637AntibacterialAnticancerDrug DeliveryMonodispersed silicaSilver nanoparticles |
| spellingShingle | Suriya Rehman Vijaya Ravinayagam Suhailah S. Al-Jameel Syed Mehmood Ali Sukainah Z. Alzayer Zahrah M. Alfaraj Atheer Alboeid Nawal Alamri Sakinah H Al Isam H. Dafallae Sugapriya Dhanasekaran Gazali Tanimu Firdos Alam Khan B. Rabindran Jermy Controlling cisplatin release by synergistic action of silver-cisplatin on monodispersed spherical silica for targeted anticancer and antibacterial activities Arabian Journal of Chemistry Antibacterial Anticancer Drug Delivery Monodispersed silica Silver nanoparticles |
| title | Controlling cisplatin release by synergistic action of silver-cisplatin on monodispersed spherical silica for targeted anticancer and antibacterial activities |
| title_full | Controlling cisplatin release by synergistic action of silver-cisplatin on monodispersed spherical silica for targeted anticancer and antibacterial activities |
| title_fullStr | Controlling cisplatin release by synergistic action of silver-cisplatin on monodispersed spherical silica for targeted anticancer and antibacterial activities |
| title_full_unstemmed | Controlling cisplatin release by synergistic action of silver-cisplatin on monodispersed spherical silica for targeted anticancer and antibacterial activities |
| title_short | Controlling cisplatin release by synergistic action of silver-cisplatin on monodispersed spherical silica for targeted anticancer and antibacterial activities |
| title_sort | controlling cisplatin release by synergistic action of silver cisplatin on monodispersed spherical silica for targeted anticancer and antibacterial activities |
| topic | Antibacterial Anticancer Drug Delivery Monodispersed silica Silver nanoparticles |
| url | http://www.sciencedirect.com/science/article/pii/S1878535224000637 |
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