Association of PTPN22-C1858T Polymorphism With Susceptibility to Mycobacterium tuberculosis and Mycobacterium leprae Infection: A Meta-Analysis
It was previously published that single-nucleotide polymorphism rs2476601 (PTPN22 [protein tyrosine phosphatase non-receptor type 22]-C1858T) might be related to increased sensibility to Mycobacterium tuberculosis and M. leprae infection. However, the results were inconclusive despite a high degree...
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.592841/full |
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| author | Shuping Li Shuping Li Xiaohua Wang Xiaohua Wang Yuming Zhao Juan Yang Juan Yang Tianjiao Cui Tianjiao Cui Zhizhuang Joe Zhao Yun Chen Zhihua Zheng Zhihua Zheng |
| author_facet | Shuping Li Shuping Li Xiaohua Wang Xiaohua Wang Yuming Zhao Juan Yang Juan Yang Tianjiao Cui Tianjiao Cui Zhizhuang Joe Zhao Yun Chen Zhihua Zheng Zhihua Zheng |
| author_sort | Shuping Li |
| collection | DOAJ |
| description | It was previously published that single-nucleotide polymorphism rs2476601 (PTPN22 [protein tyrosine phosphatase non-receptor type 22]-C1858T) might be related to increased sensibility to Mycobacterium tuberculosis and M. leprae infection. However, the results were inconclusive despite a high degree of similarity between both parameters. Herein, we carried out this meta-analysis to systematically summarize and articulate the correlation between PTPN22-C1858T polymorphism and mycobacterial infection. The susceptibility of PTPN22-C1858T carriers with autoimmune conditions receiving immunosuppressive therapy to M. tuberculosis and M. leprae infection was determined. A systematic retrieval of studies on relevance of PTPN22-C1858T polymorphism to susceptibility of M. tuberculosis or M. leprae infection was performed in Chinese National Knowledge Infrastructure, PubMed and Embase databases. We regarded Odds ratios (ORs) and 95% confidence intervals (CIs) as the determined effect size. Finally, four and two case-control studies on tuberculosis and leprosy, respectively, were included. In all genetic models, without indicated association between PTPN22-C1858T polymorphism and tuberculosis’s susceptibility. [C versus T: OR = 0.22 (95% CI: 0.09–0.50, PH = 0.887); CT versus CC: OR = 0.21 (95% CI: 0.09–0.49, PH = 0.889); TT+CT versus CC: OR = 0.21 (95% CI: 0.09–0.49, PH = 0.889)]. A significantly increased risk of leprosy was perceived in patients with the PTPN22-C1858T polymorphism [C versus T: OR = 2.82 (95% CI: 1.02–7.81, PH = 0.108)]. While the PTPN22-C1858T polymorphism is irrelevant to higher susceptibility to the infection of M. tuberculosis in Caucasians and Asians, it is relevant to increased susceptibility to the infection of M. leprae. However, the results of M. leprae are supposed to interpreted with prudence owing to the limited quantity of studies and heterogeneity. Further well-designed studies with sufficient populations are required to verify our conclusions. |
| first_indexed | 2024-12-16T07:13:40Z |
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| id | doaj.art-707348c5a3aa40219730baa9df573bde |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-16T07:13:40Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Immunology |
| spelling | doaj.art-707348c5a3aa40219730baa9df573bde2022-12-21T22:39:49ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-02-011210.3389/fimmu.2021.592841592841Association of PTPN22-C1858T Polymorphism With Susceptibility to Mycobacterium tuberculosis and Mycobacterium leprae Infection: A Meta-AnalysisShuping Li0Shuping Li1Xiaohua Wang2Xiaohua Wang3Yuming Zhao4Juan Yang5Juan Yang6Tianjiao Cui7Tianjiao Cui8Zhizhuang Joe Zhao9Yun Chen10Zhihua Zheng11Zhihua Zheng12Department of Nephrology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, ChinaCenter of Nephrology and Urology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, ChinaDepartment of Nephrology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, ChinaCenter of Nephrology and Urology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, ChinaScientific Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, ChinaDepartment of Nephrology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, ChinaCenter of Nephrology and Urology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, ChinaDepartment of Nephrology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, ChinaCenter of Nephrology and Urology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, ChinaScientific Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, ChinaScientific Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, ChinaDepartment of Nephrology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, ChinaCenter of Nephrology and Urology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, ChinaIt was previously published that single-nucleotide polymorphism rs2476601 (PTPN22 [protein tyrosine phosphatase non-receptor type 22]-C1858T) might be related to increased sensibility to Mycobacterium tuberculosis and M. leprae infection. However, the results were inconclusive despite a high degree of similarity between both parameters. Herein, we carried out this meta-analysis to systematically summarize and articulate the correlation between PTPN22-C1858T polymorphism and mycobacterial infection. The susceptibility of PTPN22-C1858T carriers with autoimmune conditions receiving immunosuppressive therapy to M. tuberculosis and M. leprae infection was determined. A systematic retrieval of studies on relevance of PTPN22-C1858T polymorphism to susceptibility of M. tuberculosis or M. leprae infection was performed in Chinese National Knowledge Infrastructure, PubMed and Embase databases. We regarded Odds ratios (ORs) and 95% confidence intervals (CIs) as the determined effect size. Finally, four and two case-control studies on tuberculosis and leprosy, respectively, were included. In all genetic models, without indicated association between PTPN22-C1858T polymorphism and tuberculosis’s susceptibility. [C versus T: OR = 0.22 (95% CI: 0.09–0.50, PH = 0.887); CT versus CC: OR = 0.21 (95% CI: 0.09–0.49, PH = 0.889); TT+CT versus CC: OR = 0.21 (95% CI: 0.09–0.49, PH = 0.889)]. A significantly increased risk of leprosy was perceived in patients with the PTPN22-C1858T polymorphism [C versus T: OR = 2.82 (95% CI: 1.02–7.81, PH = 0.108)]. While the PTPN22-C1858T polymorphism is irrelevant to higher susceptibility to the infection of M. tuberculosis in Caucasians and Asians, it is relevant to increased susceptibility to the infection of M. leprae. However, the results of M. leprae are supposed to interpreted with prudence owing to the limited quantity of studies and heterogeneity. Further well-designed studies with sufficient populations are required to verify our conclusions.https://www.frontiersin.org/articles/10.3389/fimmu.2021.592841/fullPTPN22-C1858Tsingle-nucleotide polymorphismtuberculosisleprosyMycobacterium tuberculosisMycobacterium leprae |
| spellingShingle | Shuping Li Shuping Li Xiaohua Wang Xiaohua Wang Yuming Zhao Juan Yang Juan Yang Tianjiao Cui Tianjiao Cui Zhizhuang Joe Zhao Yun Chen Zhihua Zheng Zhihua Zheng Association of PTPN22-C1858T Polymorphism With Susceptibility to Mycobacterium tuberculosis and Mycobacterium leprae Infection: A Meta-Analysis Frontiers in Immunology PTPN22-C1858T single-nucleotide polymorphism tuberculosis leprosy Mycobacterium tuberculosis Mycobacterium leprae |
| title | Association of PTPN22-C1858T Polymorphism With Susceptibility to Mycobacterium tuberculosis and Mycobacterium leprae Infection: A Meta-Analysis |
| title_full | Association of PTPN22-C1858T Polymorphism With Susceptibility to Mycobacterium tuberculosis and Mycobacterium leprae Infection: A Meta-Analysis |
| title_fullStr | Association of PTPN22-C1858T Polymorphism With Susceptibility to Mycobacterium tuberculosis and Mycobacterium leprae Infection: A Meta-Analysis |
| title_full_unstemmed | Association of PTPN22-C1858T Polymorphism With Susceptibility to Mycobacterium tuberculosis and Mycobacterium leprae Infection: A Meta-Analysis |
| title_short | Association of PTPN22-C1858T Polymorphism With Susceptibility to Mycobacterium tuberculosis and Mycobacterium leprae Infection: A Meta-Analysis |
| title_sort | association of ptpn22 c1858t polymorphism with susceptibility to mycobacterium tuberculosis and mycobacterium leprae infection a meta analysis |
| topic | PTPN22-C1858T single-nucleotide polymorphism tuberculosis leprosy Mycobacterium tuberculosis Mycobacterium leprae |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.592841/full |
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