Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination
ABSTRACTEbola disease outbreaks are major public health events because of human-to-human transmission and high mortality. These outbreaks are most often caused by Ebola virus, but at least three related viruses can also cause the disease. In 2022, Sudan virus re-emerged causing more than 160 confirm...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2265660 |
| _version_ | 1797257056985546752 |
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| author | Markus H. Kainulainen Jessica R. Harmon Amy N. Whitesell Éric Bergeron Elif Karaaslan Caitlin M. Cossaboom Jason H. Malenfant Aaron Kofman Joel M. Montgomery Mary J. Choi César G. Albariño Christina F. Spiropoulou |
| author_facet | Markus H. Kainulainen Jessica R. Harmon Amy N. Whitesell Éric Bergeron Elif Karaaslan Caitlin M. Cossaboom Jason H. Malenfant Aaron Kofman Joel M. Montgomery Mary J. Choi César G. Albariño Christina F. Spiropoulou |
| author_sort | Markus H. Kainulainen |
| collection | DOAJ |
| description | ABSTRACTEbola disease outbreaks are major public health events because of human-to-human transmission and high mortality. These outbreaks are most often caused by Ebola virus, but at least three related viruses can also cause the disease. In 2022, Sudan virus re-emerged causing more than 160 confirmed and probable cases. This report describes generation of a recombinant Sudan virus and demonstrates its utility by quantifying antibody cross-reactivity between Ebola and Sudan virus glycoproteins after human infection or vaccination with a licensed Ebola virus vaccine. |
| first_indexed | 2024-03-08T11:51:27Z |
| format | Article |
| id | doaj.art-7074e15bc8074ab7990517a437b78132 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-04-24T22:31:35Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-7074e15bc8074ab7990517a437b781322024-03-19T19:34:17ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512023-12-0112210.1080/22221751.2023.2265660Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccinationMarkus H. Kainulainen0Jessica R. Harmon1Amy N. Whitesell2Éric Bergeron3Elif Karaaslan4Caitlin M. Cossaboom5Jason H. Malenfant6Aaron Kofman7Joel M. Montgomery8Mary J. Choi9César G. Albariño10Christina F. Spiropoulou11Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USAViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USAViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USAViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USAViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USAViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USAViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USAViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USAViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USAViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USAViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USAViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USAABSTRACTEbola disease outbreaks are major public health events because of human-to-human transmission and high mortality. These outbreaks are most often caused by Ebola virus, but at least three related viruses can also cause the disease. In 2022, Sudan virus re-emerged causing more than 160 confirmed and probable cases. This report describes generation of a recombinant Sudan virus and demonstrates its utility by quantifying antibody cross-reactivity between Ebola and Sudan virus glycoproteins after human infection or vaccination with a licensed Ebola virus vaccine.https://www.tandfonline.com/doi/10.1080/22221751.2023.2265660Sudan virusrecombinant virusEbola vaccinecross-protectionneutralizing antibodies |
| spellingShingle | Markus H. Kainulainen Jessica R. Harmon Amy N. Whitesell Éric Bergeron Elif Karaaslan Caitlin M. Cossaboom Jason H. Malenfant Aaron Kofman Joel M. Montgomery Mary J. Choi César G. Albariño Christina F. Spiropoulou Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination Emerging Microbes and Infections Sudan virus recombinant virus Ebola vaccine cross-protection neutralizing antibodies |
| title | Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination |
| title_full | Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination |
| title_fullStr | Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination |
| title_full_unstemmed | Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination |
| title_short | Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination |
| title_sort | recombinant sudan virus and evaluation of humoral cross reactivity between ebola and sudan virus glycoproteins after infection or rvsv δg zebov gp vaccination |
| topic | Sudan virus recombinant virus Ebola vaccine cross-protection neutralizing antibodies |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2265660 |
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