The anatomic determinants of conductive hearing loss secondary to tympanic membrane perforation
Objectives: Recent studies have introduced middle ear volume (MEV) as a novel determinant of perforation-induced conductive hearing loss (CHL) in a mechanism driven by trans-tympanic membrane pressure differences. The primary aims of this preliminary report are to: 1) correlate CHL with perforation...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-09-01
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| Series: | Journal of Otology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1672293017300351 |
| _version_ | 1811268052898021376 |
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| author | David J. Carpenter Debara L. Tucci David M. Kaylie Dennis O. Frank-Ito |
| author_facet | David J. Carpenter Debara L. Tucci David M. Kaylie Dennis O. Frank-Ito |
| author_sort | David J. Carpenter |
| collection | DOAJ |
| description | Objectives: Recent studies have introduced middle ear volume (MEV) as a novel determinant of perforation-induced conductive hearing loss (CHL) in a mechanism driven by trans-tympanic membrane pressure differences. The primary aims of this preliminary report are to: 1) correlate CHL with perforation size; 2) describe the relationship between CHL and MEV; and 3) compare CHL across a range of cholesteatoma involvement. Design: A retrospective pilot study was performed in 31 subjects with audiometry indicative of conductive hearing loss, temporal bone CT scans, and no prior middle ear surgery. Perforation size and MEV were analyzed with respect to CHL in a cohort of 10 perforated ears with no cholesteatoma. CHLs were compared in 3 groups defined by extent of cholesteatoma involvement. Results: Ears with large and small perforations showed mean ABG values of 32.0 ± 15.7 dB and 16.0 ± 16.4 dB, respectively. A direct relationship was observed between MEV and CHL for ears with large perforations across all frequencies, whereas this relationship for small perforations was frequency-dependent. Finally, a statistically significant increase in CHL was found across ears with increasing cholesteatoma involvement at 1000 Hz (χ2(2) = 9.786, p = 0.008), 2000 Hz (χ2(2) = 8.455, p = 0.015), and 4000 Hz (χ2(2) = 8.253, p = 0.016). Conclusions: These pilot data suggest that greater perforation-induced conductive hearing losses may be associated with larger perforation sizes and cholesteatoma. The correlation between MEV and CHL may require additional study. Keywords: Perforation-induced hearing loss, Conductive hearing loss, Middle ear volume, Three-dimensional volume reconstruction |
| first_indexed | 2024-04-12T21:15:08Z |
| format | Article |
| id | doaj.art-70762c225f9d46b68af0295407bc4eda |
| institution | Directory Open Access Journal |
| issn | 1672-2930 |
| language | English |
| last_indexed | 2024-04-12T21:15:08Z |
| publishDate | 2017-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Otology |
| spelling | doaj.art-70762c225f9d46b68af0295407bc4eda2022-12-22T03:16:29ZengElsevierJournal of Otology1672-29302017-09-01123125131The anatomic determinants of conductive hearing loss secondary to tympanic membrane perforationDavid J. Carpenter0Debara L. Tucci1David M. Kaylie2Dennis O. Frank-Ito3Division of Head and Neck Surgery & Communication Sciences, Department of Surgery, Duke University Medical Center, Durham, NC, USA; Corresponding author. Duke Department of Head and Neck Surgery & Communication Sciences, Duke University Medical Center, Room 3561 – Blue Zone, Durham, NC, 27710, USA. Fax: +1 919 681 7949.Division of Head and Neck Surgery & Communication Sciences, Department of Surgery, Duke University Medical Center, Durham, NC, USADivision of Head and Neck Surgery & Communication Sciences, Department of Surgery, Duke University Medical Center, Durham, NC, USADivision of Head and Neck Surgery & Communication Sciences, Department of Surgery, Duke University Medical Center, Durham, NC, USA; Computational Biology & Bioinformatics PhD Program, Duke University, Durham, NC, USA; Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USAObjectives: Recent studies have introduced middle ear volume (MEV) as a novel determinant of perforation-induced conductive hearing loss (CHL) in a mechanism driven by trans-tympanic membrane pressure differences. The primary aims of this preliminary report are to: 1) correlate CHL with perforation size; 2) describe the relationship between CHL and MEV; and 3) compare CHL across a range of cholesteatoma involvement. Design: A retrospective pilot study was performed in 31 subjects with audiometry indicative of conductive hearing loss, temporal bone CT scans, and no prior middle ear surgery. Perforation size and MEV were analyzed with respect to CHL in a cohort of 10 perforated ears with no cholesteatoma. CHLs were compared in 3 groups defined by extent of cholesteatoma involvement. Results: Ears with large and small perforations showed mean ABG values of 32.0 ± 15.7 dB and 16.0 ± 16.4 dB, respectively. A direct relationship was observed between MEV and CHL for ears with large perforations across all frequencies, whereas this relationship for small perforations was frequency-dependent. Finally, a statistically significant increase in CHL was found across ears with increasing cholesteatoma involvement at 1000 Hz (χ2(2) = 9.786, p = 0.008), 2000 Hz (χ2(2) = 8.455, p = 0.015), and 4000 Hz (χ2(2) = 8.253, p = 0.016). Conclusions: These pilot data suggest that greater perforation-induced conductive hearing losses may be associated with larger perforation sizes and cholesteatoma. The correlation between MEV and CHL may require additional study. Keywords: Perforation-induced hearing loss, Conductive hearing loss, Middle ear volume, Three-dimensional volume reconstructionhttp://www.sciencedirect.com/science/article/pii/S1672293017300351 |
| spellingShingle | David J. Carpenter Debara L. Tucci David M. Kaylie Dennis O. Frank-Ito The anatomic determinants of conductive hearing loss secondary to tympanic membrane perforation Journal of Otology |
| title | The anatomic determinants of conductive hearing loss secondary to tympanic membrane perforation |
| title_full | The anatomic determinants of conductive hearing loss secondary to tympanic membrane perforation |
| title_fullStr | The anatomic determinants of conductive hearing loss secondary to tympanic membrane perforation |
| title_full_unstemmed | The anatomic determinants of conductive hearing loss secondary to tympanic membrane perforation |
| title_short | The anatomic determinants of conductive hearing loss secondary to tympanic membrane perforation |
| title_sort | anatomic determinants of conductive hearing loss secondary to tympanic membrane perforation |
| url | http://www.sciencedirect.com/science/article/pii/S1672293017300351 |
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