Evaluation of the immune response of dogs after a mass vaccination campaign against rabies in Tunisia
Abstract Background Rabies (RABV) is an enzootic disease in Tunisia, with dogs being the primary reservoir. Vaccinating dogs is the key to eradicate rabies. Regional Veterinary Services conduct nationwide immunisation campaigns on an annual basis. Evaluation of the immune response is still important...
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | BMC Veterinary Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12917-023-03582-8 |
| _version_ | 1811171698412617728 |
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| author | Mariem Handous Imed Turki Abdejelil Ghram Samia BenMaiz Jihen Bensalem Nourhene Basdouri Mohamed Soltani Farah Bassalah Habib Kharmachi |
| author_facet | Mariem Handous Imed Turki Abdejelil Ghram Samia BenMaiz Jihen Bensalem Nourhene Basdouri Mohamed Soltani Farah Bassalah Habib Kharmachi |
| author_sort | Mariem Handous |
| collection | DOAJ |
| description | Abstract Background Rabies (RABV) is an enzootic disease in Tunisia, with dogs being the primary reservoir. Vaccinating dogs is the key to eradicate rabies. Regional Veterinary Services conduct nationwide immunisation campaigns on an annual basis. Evaluation of the immune response is still important to make sure that the vaccination is effective in the conditions of the Tunisian field. In this paper, the FAVN technique was used to test rabies antibody dynamics in dogs from three distinct Tunisian areas observed for one year following a mass vaccination campaign. Results On day 30 after vaccination, 75% of all dogs vaccinated during the campaign were sero-positive (titres greater than or equal to 0.5 transformed IU/ml). On day 180, 48% of all dogs were sero-positive. Only 25.6% of primary-vaccinated dogs remained sero-positive on day 180 and 7% on day 365, whereas 91% of previously sero-positive dogs remained sero-positive on day 365. Conclusions Although a single rabies vaccine is successful at stimulating an immunological response, it is recommended that primary-vaccinated dogs have a second booster between one and three months after the initial vaccination to maintain seropositivity. To achieve the rabies eradication objective, all dogs should receive an annual booster to maintain effective immunological protection. |
| first_indexed | 2024-04-10T17:18:21Z |
| format | Article |
| id | doaj.art-7076c007f8c945009bc5832494a36436 |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-04-10T17:18:21Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-7076c007f8c945009bc5832494a364362023-02-05T12:15:46ZengBMCBMC Veterinary Research1746-61482023-01-0119111010.1186/s12917-023-03582-8Evaluation of the immune response of dogs after a mass vaccination campaign against rabies in TunisiaMariem Handous0Imed Turki1Abdejelil Ghram2Samia BenMaiz3Jihen Bensalem4Nourhene Basdouri5Mohamed Soltani6Farah Bassalah7Habib Kharmachi8University of Tunis El Manar, Rabies Laboratory, Institut Pasteur of TunisUniversity of Tunis El Manar, Rabies Laboratory, Institut Pasteur of TunisUniversity of Tunis El Manar, Rabies Laboratory, Institut Pasteur of TunisUniversity of Tunis El Manar, Rabies Laboratory, Institut Pasteur of TunisUniversity of Tunis El Manar, Rabies Laboratory, Institut Pasteur of TunisUniversity of Tunis El Manar, Rabies Laboratory, Institut Pasteur of TunisUniversity of Tunis El Manar, Rabies Laboratory, Institut Pasteur of TunisUniversity of Tunis El Manar, Rabies Laboratory, Institut Pasteur of TunisUniversity of Tunis El Manar, Rabies Laboratory, Institut Pasteur of TunisAbstract Background Rabies (RABV) is an enzootic disease in Tunisia, with dogs being the primary reservoir. Vaccinating dogs is the key to eradicate rabies. Regional Veterinary Services conduct nationwide immunisation campaigns on an annual basis. Evaluation of the immune response is still important to make sure that the vaccination is effective in the conditions of the Tunisian field. In this paper, the FAVN technique was used to test rabies antibody dynamics in dogs from three distinct Tunisian areas observed for one year following a mass vaccination campaign. Results On day 30 after vaccination, 75% of all dogs vaccinated during the campaign were sero-positive (titres greater than or equal to 0.5 transformed IU/ml). On day 180, 48% of all dogs were sero-positive. Only 25.6% of primary-vaccinated dogs remained sero-positive on day 180 and 7% on day 365, whereas 91% of previously sero-positive dogs remained sero-positive on day 365. Conclusions Although a single rabies vaccine is successful at stimulating an immunological response, it is recommended that primary-vaccinated dogs have a second booster between one and three months after the initial vaccination to maintain seropositivity. To achieve the rabies eradication objective, all dogs should receive an annual booster to maintain effective immunological protection.https://doi.org/10.1186/s12917-023-03582-8Rabies virusDogsImmune responseFAVN |
| spellingShingle | Mariem Handous Imed Turki Abdejelil Ghram Samia BenMaiz Jihen Bensalem Nourhene Basdouri Mohamed Soltani Farah Bassalah Habib Kharmachi Evaluation of the immune response of dogs after a mass vaccination campaign against rabies in Tunisia BMC Veterinary Research Rabies virus Dogs Immune response FAVN |
| title | Evaluation of the immune response of dogs after a mass vaccination campaign against rabies in Tunisia |
| title_full | Evaluation of the immune response of dogs after a mass vaccination campaign against rabies in Tunisia |
| title_fullStr | Evaluation of the immune response of dogs after a mass vaccination campaign against rabies in Tunisia |
| title_full_unstemmed | Evaluation of the immune response of dogs after a mass vaccination campaign against rabies in Tunisia |
| title_short | Evaluation of the immune response of dogs after a mass vaccination campaign against rabies in Tunisia |
| title_sort | evaluation of the immune response of dogs after a mass vaccination campaign against rabies in tunisia |
| topic | Rabies virus Dogs Immune response FAVN |
| url | https://doi.org/10.1186/s12917-023-03582-8 |
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