Sirtuin 3 relieves inflammatory responses elicited by lipopolysaccharide via the PGC1α-NFκB pathway in bovine mammary epithelial cells

Sirtuin 3 relieves inflammatory responses elicited by lipopolysaccharide via the PGC1α-NFκB pathway in bovine mammary epithelial cells

ABSTRACT: Excessive inflammation in bovine mammary endothelial cells (BMEC) due to mastitis leads to disease progression and eventual culling of cattle. Sirtuin 3 (SIRT3), a mitochondrial deacetylase, downregulates pro-inflammatory cytokines in BMEC exposed to high concentrations of nonesterified fa...

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Bibliographic Details
Main Authors: Lei Liu, Baogen Wang, Wei Yang, Qianming Jiang, Juan J. Loor, Lu Ouyang, Huilun Tang, Renxu Chang, Tao Peng, Chuang Xu
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Journal of Dairy Science
Subjects:
dairy cattle
Sirtuin 3
PGC1α
nuclear factor-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S002203022200707X

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