Resistance Levels and Epidemiology of Non-Fermenting Gram-Negative Bacteria in Urinary Tract Infections of Inpatients and Outpatients (RENFUTI): A 10-Year Epidemiological Snapshot
<i>Background:</i> Urinary tract infections (UTIs) are one of the most common infections in the human medicine, both among outpatients and inpatients. There is an increasing appreciation for the pathogenic role of non-fermenting Gram-negative bacteria (NFGNBs) in UTIs, particularly in th...
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| Language: | English |
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MDPI AG
2019-09-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/8/3/143 |
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| author | Márió Gajdács Katalin Burián Gabriella Terhes |
| author_facet | Márió Gajdács Katalin Burián Gabriella Terhes |
| author_sort | Márió Gajdács |
| collection | DOAJ |
| description | <i>Background:</i> Urinary tract infections (UTIs) are one of the most common infections in the human medicine, both among outpatients and inpatients. There is an increasing appreciation for the pathogenic role of non-fermenting Gram-negative bacteria (NFGNBs) in UTIs, particularly in the presence of underlying illnesses. <i>Methods:</i> The study was carried out using data regarding a 10-year period (2008–2017). The antimicrobial susceptibility testing was performed using the disk diffusion method, E-tests, and broth microdilution. <i>Results:</i> NFGNB represented 3.46% ± 0.93% for the outpatients, while 6.43% ± 0.81% of all positive urine samples for the inpatients (<i>p</i> < 0.001). In both groups, <i>Pseudomonas</i> spp. (78.7% compared to 85.1%) and <i>Acinetobacter</i> spp. (19.6% compared to 10.9%), were the most prevalent. The <i>Acinetobacter</i> resistance levels were significantly higher in inpatients isolates (<i>p</i> values ranging between 0.046 and <0.001), while the differences in the resistance levels of <i>Pseudomonas</i> was not as pronounced. The <i>β</i>-lactam-resistance levels were between 15–25% and 12–28% for the <i>Acinetobacter</i> and <i>Pseudomonas</i> spp., respectively. 4.71% of <i>Acinetobacter</i> and 1.67% of <i>Pseudomonas</i> were extensively drug resistant (XDR); no colistin-resistant isolates were recovered. <i>Conclusions:</i> Increasing resistance levels of the <i>Acinetobacter</i> spp. from 2013 onward, but not in the case of the <i>Pseudomonas</i> spp. Although rare, the drug resistant NFGNB in UTIs present a concerning therapeutic challenge to clinicians with few therapeutic options left. |
| first_indexed | 2024-04-12T01:28:37Z |
| format | Article |
| id | doaj.art-7079572e03a74367b89e355aeb068e27 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-04-12T01:28:37Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-7079572e03a74367b89e355aeb068e272022-12-22T03:53:34ZengMDPI AGAntibiotics2079-63822019-09-018314310.3390/antibiotics8030143antibiotics8030143Resistance Levels and Epidemiology of Non-Fermenting Gram-Negative Bacteria in Urinary Tract Infections of Inpatients and Outpatients (RENFUTI): A 10-Year Epidemiological SnapshotMárió Gajdács0Katalin Burián1Gabriella Terhes2Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Eötvös utca 6, 6720 Szeged, HungaryDepartment of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, 6720 Szeged, HungaryInstitute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Semmelweis utca 6, 6725 Szeged, Hungary<i>Background:</i> Urinary tract infections (UTIs) are one of the most common infections in the human medicine, both among outpatients and inpatients. There is an increasing appreciation for the pathogenic role of non-fermenting Gram-negative bacteria (NFGNBs) in UTIs, particularly in the presence of underlying illnesses. <i>Methods:</i> The study was carried out using data regarding a 10-year period (2008–2017). The antimicrobial susceptibility testing was performed using the disk diffusion method, E-tests, and broth microdilution. <i>Results:</i> NFGNB represented 3.46% ± 0.93% for the outpatients, while 6.43% ± 0.81% of all positive urine samples for the inpatients (<i>p</i> < 0.001). In both groups, <i>Pseudomonas</i> spp. (78.7% compared to 85.1%) and <i>Acinetobacter</i> spp. (19.6% compared to 10.9%), were the most prevalent. The <i>Acinetobacter</i> resistance levels were significantly higher in inpatients isolates (<i>p</i> values ranging between 0.046 and <0.001), while the differences in the resistance levels of <i>Pseudomonas</i> was not as pronounced. The <i>β</i>-lactam-resistance levels were between 15–25% and 12–28% for the <i>Acinetobacter</i> and <i>Pseudomonas</i> spp., respectively. 4.71% of <i>Acinetobacter</i> and 1.67% of <i>Pseudomonas</i> were extensively drug resistant (XDR); no colistin-resistant isolates were recovered. <i>Conclusions:</i> Increasing resistance levels of the <i>Acinetobacter</i> spp. from 2013 onward, but not in the case of the <i>Pseudomonas</i> spp. Although rare, the drug resistant NFGNB in UTIs present a concerning therapeutic challenge to clinicians with few therapeutic options left.https://www.mdpi.com/2079-6382/8/3/143urinary tract infectionUTIantibioticresistanceepidemiologynon-fermenting<i>Acinetobacter</i><i>Pseudomonas</i><i>Stenotrophomonas</i> |
| spellingShingle | Márió Gajdács Katalin Burián Gabriella Terhes Resistance Levels and Epidemiology of Non-Fermenting Gram-Negative Bacteria in Urinary Tract Infections of Inpatients and Outpatients (RENFUTI): A 10-Year Epidemiological Snapshot Antibiotics urinary tract infection UTI antibiotic resistance epidemiology non-fermenting <i>Acinetobacter</i> <i>Pseudomonas</i> <i>Stenotrophomonas</i> |
| title | Resistance Levels and Epidemiology of Non-Fermenting Gram-Negative Bacteria in Urinary Tract Infections of Inpatients and Outpatients (RENFUTI): A 10-Year Epidemiological Snapshot |
| title_full | Resistance Levels and Epidemiology of Non-Fermenting Gram-Negative Bacteria in Urinary Tract Infections of Inpatients and Outpatients (RENFUTI): A 10-Year Epidemiological Snapshot |
| title_fullStr | Resistance Levels and Epidemiology of Non-Fermenting Gram-Negative Bacteria in Urinary Tract Infections of Inpatients and Outpatients (RENFUTI): A 10-Year Epidemiological Snapshot |
| title_full_unstemmed | Resistance Levels and Epidemiology of Non-Fermenting Gram-Negative Bacteria in Urinary Tract Infections of Inpatients and Outpatients (RENFUTI): A 10-Year Epidemiological Snapshot |
| title_short | Resistance Levels and Epidemiology of Non-Fermenting Gram-Negative Bacteria in Urinary Tract Infections of Inpatients and Outpatients (RENFUTI): A 10-Year Epidemiological Snapshot |
| title_sort | resistance levels and epidemiology of non fermenting gram negative bacteria in urinary tract infections of inpatients and outpatients renfuti a 10 year epidemiological snapshot |
| topic | urinary tract infection UTI antibiotic resistance epidemiology non-fermenting <i>Acinetobacter</i> <i>Pseudomonas</i> <i>Stenotrophomonas</i> |
| url | https://www.mdpi.com/2079-6382/8/3/143 |
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