A review of antibiotic resistance among Campylobacter species in human, animal, and water sources in South Africa: a One Health Approach
Campylobacter species are among the aetiological agents responsible for 400–500 million human diarrhoea cases per annum. The risk of dissemination of antibiotic-resistant Campylobacter species between humans, animals, and the environment is anticipated, given its transmissibility through these sourc...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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IWA Publishing
2023-01-01
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| Series: | Journal of Water and Health |
| Subjects: | |
| Online Access: | http://jwh.iwaponline.com/content/21/1/9 |
| _version_ | 1797903447321739264 |
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| author | Mary Chibwe Oghenekaro Nelson Odume Chika Felicitas Nnadozie |
| author_facet | Mary Chibwe Oghenekaro Nelson Odume Chika Felicitas Nnadozie |
| author_sort | Mary Chibwe |
| collection | DOAJ |
| description | Campylobacter species are among the aetiological agents responsible for 400–500 million human diarrhoea cases per annum. The risk of dissemination of antibiotic-resistant Campylobacter species between humans, animals, and the environment is anticipated, given its transmissibility through these sources. The objective of this paper is to present a situation analysis that reports the current patterns and determinants of Campylobacter antibiotic resistance in South Africa. This review applies the One Health (OH) Approach to systematically review and collate the current antibiotic resistance status among Campylobacter spp. in South Africa. The highest level of resistance of Campylobacter in humans is to azithromycin (69.7%), whereas the lowest level of resistance of Campylobacter is to gatifloxacin (8.3%). In animals, high resistance to common antibiotics erythromycin (95.06%), clindamycin (95.68%), doxycycline (87.65%), erythromycin (90%), tetracycline (84.3%), streptomycin (88%), and ampicillin (73%) while 100% resistance of Campylobacter from water samples to tetracycline, imipenem, is recorded. Furthermore, resistance to clarithromycin (95%), azithromycin (92%), clindamycin (84.2%), doxycycline (80%), and ciprofloxacin (77.8%) is reported among Campylobacter spp. from water samples. The genetic similarity results suggest the movement of antibiotic-resistant Campylobacter spp. between humans and the environment. More research on antibiotic resistance among Campylobacter from other sources, outside clinical isolates, is recommended.
HIGHLIGHTS
High antibiotic resistance among Campylobacter isolates from humans, animals, and water in South Africa is observed.;
There is an increased risk of waterborne antibiotic-resistant Campylobacter infections for communities that rely on the rivers for domestic and agricultural (irrigation) purposes.;
More investigations of antibiotic resistance in Campylobacter of aquatic environmental origin are emphasised.; |
| first_indexed | 2024-04-10T09:33:06Z |
| format | Article |
| id | doaj.art-707b865abd1844b0b12924d20b5aa78b |
| institution | Directory Open Access Journal |
| issn | 1477-8920 1996-7829 |
| language | English |
| last_indexed | 2024-04-10T09:33:06Z |
| publishDate | 2023-01-01 |
| publisher | IWA Publishing |
| record_format | Article |
| series | Journal of Water and Health |
| spelling | doaj.art-707b865abd1844b0b12924d20b5aa78b2023-02-18T09:20:20ZengIWA PublishingJournal of Water and Health1477-89201996-78292023-01-0121192610.2166/wh.2022.146146A review of antibiotic resistance among Campylobacter species in human, animal, and water sources in South Africa: a One Health ApproachMary Chibwe0Oghenekaro Nelson Odume1Chika Felicitas Nnadozie2 Institute for Water Research (IWR), Rhodes University, Old Geology Building (off Artillery Road), P.O. Box 94, Grahamstown 6140, South Africa Institute for Water Research (IWR), Rhodes University, Old Geology Building (off Artillery Road), P.O. Box 94, Grahamstown 6140, South Africa Institute for Water Research (IWR), Rhodes University, Old Geology Building (off Artillery Road), P.O. Box 94, Grahamstown 6140, South Africa Campylobacter species are among the aetiological agents responsible for 400–500 million human diarrhoea cases per annum. The risk of dissemination of antibiotic-resistant Campylobacter species between humans, animals, and the environment is anticipated, given its transmissibility through these sources. The objective of this paper is to present a situation analysis that reports the current patterns and determinants of Campylobacter antibiotic resistance in South Africa. This review applies the One Health (OH) Approach to systematically review and collate the current antibiotic resistance status among Campylobacter spp. in South Africa. The highest level of resistance of Campylobacter in humans is to azithromycin (69.7%), whereas the lowest level of resistance of Campylobacter is to gatifloxacin (8.3%). In animals, high resistance to common antibiotics erythromycin (95.06%), clindamycin (95.68%), doxycycline (87.65%), erythromycin (90%), tetracycline (84.3%), streptomycin (88%), and ampicillin (73%) while 100% resistance of Campylobacter from water samples to tetracycline, imipenem, is recorded. Furthermore, resistance to clarithromycin (95%), azithromycin (92%), clindamycin (84.2%), doxycycline (80%), and ciprofloxacin (77.8%) is reported among Campylobacter spp. from water samples. The genetic similarity results suggest the movement of antibiotic-resistant Campylobacter spp. between humans and the environment. More research on antibiotic resistance among Campylobacter from other sources, outside clinical isolates, is recommended. HIGHLIGHTS High antibiotic resistance among Campylobacter isolates from humans, animals, and water in South Africa is observed.; There is an increased risk of waterborne antibiotic-resistant Campylobacter infections for communities that rely on the rivers for domestic and agricultural (irrigation) purposes.; More investigations of antibiotic resistance in Campylobacter of aquatic environmental origin are emphasised.;http://jwh.iwaponline.com/content/21/1/9antibiotic-resistancecampylobacterenvironmental watershumans |
| spellingShingle | Mary Chibwe Oghenekaro Nelson Odume Chika Felicitas Nnadozie A review of antibiotic resistance among Campylobacter species in human, animal, and water sources in South Africa: a One Health Approach Journal of Water and Health antibiotic-resistance campylobacter environmental waters humans |
| title | A review of antibiotic resistance among Campylobacter species in human, animal, and water sources in South Africa: a One Health Approach |
| title_full | A review of antibiotic resistance among Campylobacter species in human, animal, and water sources in South Africa: a One Health Approach |
| title_fullStr | A review of antibiotic resistance among Campylobacter species in human, animal, and water sources in South Africa: a One Health Approach |
| title_full_unstemmed | A review of antibiotic resistance among Campylobacter species in human, animal, and water sources in South Africa: a One Health Approach |
| title_short | A review of antibiotic resistance among Campylobacter species in human, animal, and water sources in South Africa: a One Health Approach |
| title_sort | review of antibiotic resistance among campylobacter species in human animal and water sources in south africa a one health approach |
| topic | antibiotic-resistance campylobacter environmental waters humans |
| url | http://jwh.iwaponline.com/content/21/1/9 |
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