Computable early Caenorhabditis elegans embryo with a phase field model.
Morphogenesis is a precise and robust dynamic process during metazoan embryogenesis, consisting of both cell proliferation and cell migration. Despite the fact that much is known about specific regulations at molecular level, how cell proliferation and migration together drive the morphogenesis at c...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
|
| Series: | PLoS Computational Biology |
| Online Access: | https://doi.org/10.1371/journal.pcbi.1009755 |
| _version_ | 1819319660625002496 |
|---|---|
| author | Xiangyu Kuang Guoye Guan Ming-Kin Wong Lu-Yan Chan Zhongying Zhao Chao Tang Lei Zhang |
| author_facet | Xiangyu Kuang Guoye Guan Ming-Kin Wong Lu-Yan Chan Zhongying Zhao Chao Tang Lei Zhang |
| author_sort | Xiangyu Kuang |
| collection | DOAJ |
| description | Morphogenesis is a precise and robust dynamic process during metazoan embryogenesis, consisting of both cell proliferation and cell migration. Despite the fact that much is known about specific regulations at molecular level, how cell proliferation and migration together drive the morphogenesis at cellular and organismic levels is not well understood. Using Caenorhabditis elegans as the model animal, we present a phase field model to compute early embryonic morphogenesis within a confined eggshell. With physical information about cell division obtained from three-dimensional time-lapse cellular imaging experiments, the model can precisely reproduce the early morphogenesis process as seen in vivo, including time evolution of location and morphology of each cell. Furthermore, the model can be used to reveal key cell-cell attractions critical to the development of C. elegans embryo. Our work demonstrates how genetic programming and physical forces collaborate to drive morphogenesis and provides a predictive model to decipher the underlying mechanism. |
| first_indexed | 2024-12-24T11:07:13Z |
| format | Article |
| id | doaj.art-707c15cf43b3473da0de45dd97e20700 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-24T11:07:13Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-707c15cf43b3473da0de45dd97e207002022-12-21T16:58:37ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582022-01-01181e100975510.1371/journal.pcbi.1009755Computable early Caenorhabditis elegans embryo with a phase field model.Xiangyu KuangGuoye GuanMing-Kin WongLu-Yan ChanZhongying ZhaoChao TangLei ZhangMorphogenesis is a precise and robust dynamic process during metazoan embryogenesis, consisting of both cell proliferation and cell migration. Despite the fact that much is known about specific regulations at molecular level, how cell proliferation and migration together drive the morphogenesis at cellular and organismic levels is not well understood. Using Caenorhabditis elegans as the model animal, we present a phase field model to compute early embryonic morphogenesis within a confined eggshell. With physical information about cell division obtained from three-dimensional time-lapse cellular imaging experiments, the model can precisely reproduce the early morphogenesis process as seen in vivo, including time evolution of location and morphology of each cell. Furthermore, the model can be used to reveal key cell-cell attractions critical to the development of C. elegans embryo. Our work demonstrates how genetic programming and physical forces collaborate to drive morphogenesis and provides a predictive model to decipher the underlying mechanism.https://doi.org/10.1371/journal.pcbi.1009755 |
| spellingShingle | Xiangyu Kuang Guoye Guan Ming-Kin Wong Lu-Yan Chan Zhongying Zhao Chao Tang Lei Zhang Computable early Caenorhabditis elegans embryo with a phase field model. PLoS Computational Biology |
| title | Computable early Caenorhabditis elegans embryo with a phase field model. |
| title_full | Computable early Caenorhabditis elegans embryo with a phase field model. |
| title_fullStr | Computable early Caenorhabditis elegans embryo with a phase field model. |
| title_full_unstemmed | Computable early Caenorhabditis elegans embryo with a phase field model. |
| title_short | Computable early Caenorhabditis elegans embryo with a phase field model. |
| title_sort | computable early caenorhabditis elegans embryo with a phase field model |
| url | https://doi.org/10.1371/journal.pcbi.1009755 |
| work_keys_str_mv | AT xiangyukuang computableearlycaenorhabditiselegansembryowithaphasefieldmodel AT guoyeguan computableearlycaenorhabditiselegansembryowithaphasefieldmodel AT mingkinwong computableearlycaenorhabditiselegansembryowithaphasefieldmodel AT luyanchan computableearlycaenorhabditiselegansembryowithaphasefieldmodel AT zhongyingzhao computableearlycaenorhabditiselegansembryowithaphasefieldmodel AT chaotang computableearlycaenorhabditiselegansembryowithaphasefieldmodel AT leizhang computableearlycaenorhabditiselegansembryowithaphasefieldmodel |