Antigen-Presenting Cells in Psoriasis
Psoriasis is classically considered a chronic inflammatory skin disorder, however the identification of autoantigens in its pathogenesis established it as a T cell mediated autoimmune disease. As such professional antigen-presenting cells (APCs) are key players in the development of lesions. APCs in...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/12/2/234 |
| _version_ | 1827654226460803072 |
|---|---|
| author | Dóra Antal Shahrzad Alimohammadi Péter Bai Attila Gábor Szöllősi Magdolna Szántó |
| author_facet | Dóra Antal Shahrzad Alimohammadi Péter Bai Attila Gábor Szöllősi Magdolna Szántó |
| author_sort | Dóra Antal |
| collection | DOAJ |
| description | Psoriasis is classically considered a chronic inflammatory skin disorder, however the identification of autoantigens in its pathogenesis established it as a T cell mediated autoimmune disease. As such professional antigen-presenting cells (APCs) are key players in the development of lesions. APCs in the skin include dendritic cells, Langerhans cells and monocytes/macrophages. In addition, epidermal keratinocytes and dermal mast cells are also endowed with antigen-presenting capacity. Skin APCs have central role in the maintenance of cutaneous immune homeostasis, as well as in initiating and sustaining inflammation under pathologic conditions. In this review we discuss the functional specialization of human skin APCs that promote T cell activation and adaptive immune response during psoriasis initiation and onset. |
| first_indexed | 2024-03-09T21:35:23Z |
| format | Article |
| id | doaj.art-707d80137c9d41758df87b288ae863f3 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T21:35:23Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-707d80137c9d41758df87b288ae863f32023-11-23T20:46:11ZengMDPI AGLife2075-17292022-02-0112223410.3390/life12020234Antigen-Presenting Cells in PsoriasisDóra Antal0Shahrzad Alimohammadi1Péter Bai2Attila Gábor Szöllősi3Magdolna Szántó4Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Immunology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Immunology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryPsoriasis is classically considered a chronic inflammatory skin disorder, however the identification of autoantigens in its pathogenesis established it as a T cell mediated autoimmune disease. As such professional antigen-presenting cells (APCs) are key players in the development of lesions. APCs in the skin include dendritic cells, Langerhans cells and monocytes/macrophages. In addition, epidermal keratinocytes and dermal mast cells are also endowed with antigen-presenting capacity. Skin APCs have central role in the maintenance of cutaneous immune homeostasis, as well as in initiating and sustaining inflammation under pathologic conditions. In this review we discuss the functional specialization of human skin APCs that promote T cell activation and adaptive immune response during psoriasis initiation and onset.https://www.mdpi.com/2075-1729/12/2/234psoriasisantigen-presenting cellsautoantigenskeratinocytemast cellneuropeptide |
| spellingShingle | Dóra Antal Shahrzad Alimohammadi Péter Bai Attila Gábor Szöllősi Magdolna Szántó Antigen-Presenting Cells in Psoriasis Life psoriasis antigen-presenting cells autoantigens keratinocyte mast cell neuropeptide |
| title | Antigen-Presenting Cells in Psoriasis |
| title_full | Antigen-Presenting Cells in Psoriasis |
| title_fullStr | Antigen-Presenting Cells in Psoriasis |
| title_full_unstemmed | Antigen-Presenting Cells in Psoriasis |
| title_short | Antigen-Presenting Cells in Psoriasis |
| title_sort | antigen presenting cells in psoriasis |
| topic | psoriasis antigen-presenting cells autoantigens keratinocyte mast cell neuropeptide |
| url | https://www.mdpi.com/2075-1729/12/2/234 |
| work_keys_str_mv | AT doraantal antigenpresentingcellsinpsoriasis AT shahrzadalimohammadi antigenpresentingcellsinpsoriasis AT peterbai antigenpresentingcellsinpsoriasis AT attilagaborszollosi antigenpresentingcellsinpsoriasis AT magdolnaszanto antigenpresentingcellsinpsoriasis |