Matrix Metalloproteinases and Glaucoma
Matrix metalloproteinases (MMPs) are enzymes that decompose extracellular matrix (ECM) proteins. MMPs are thought to play important roles in cellular processes, such as cell proliferation, differentiation, angiogenesis, migration, apoptosis, and host defense. MMPs are distributed in almost all intra...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/10/1368 |
| _version_ | 1797474928669229056 |
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| author | Moo Hyun Kim Su-Ho Lim |
| author_facet | Moo Hyun Kim Su-Ho Lim |
| author_sort | Moo Hyun Kim |
| collection | DOAJ |
| description | Matrix metalloproteinases (MMPs) are enzymes that decompose extracellular matrix (ECM) proteins. MMPs are thought to play important roles in cellular processes, such as cell proliferation, differentiation, angiogenesis, migration, apoptosis, and host defense. MMPs are distributed in almost all intraocular tissues and are involved in physiological and pathological mechanisms of the eye. MMPs are also associated with glaucoma, a progressive neurodegenerative disease of the eyes. MMP activity affects intraocular pressure control and apoptosis of retinal ganglion cells, which are the pathological mechanisms of glaucoma. It also affects the risk of glaucoma development based on genetic pleomorphism. In addition, MMPs may affect the treatment outcomes of glaucoma, including the success rate of surgical treatment and side effects on the ocular surface due to glaucoma medications. This review discusses the various relationships between MMP and glaucoma. |
| first_indexed | 2024-03-09T20:36:58Z |
| format | Article |
| id | doaj.art-707e0c957edc4fd79e86251325b44ce9 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T20:36:58Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-707e0c957edc4fd79e86251325b44ce92023-11-23T23:07:31ZengMDPI AGBiomolecules2218-273X2022-09-011210136810.3390/biom12101368Matrix Metalloproteinases and GlaucomaMoo Hyun Kim0Su-Ho Lim1Department of Ophthalmology, Daegu Premier Eye Center, Suseong-ro 197, Suseong-Gu, Daegu 42153, KoreaDepartment of Ophthalmology, Daegu Veterans Health Service Medical Center, 60 Wolgok-Ro, Dalseo-Gu, Daegu 42835, KoreaMatrix metalloproteinases (MMPs) are enzymes that decompose extracellular matrix (ECM) proteins. MMPs are thought to play important roles in cellular processes, such as cell proliferation, differentiation, angiogenesis, migration, apoptosis, and host defense. MMPs are distributed in almost all intraocular tissues and are involved in physiological and pathological mechanisms of the eye. MMPs are also associated with glaucoma, a progressive neurodegenerative disease of the eyes. MMP activity affects intraocular pressure control and apoptosis of retinal ganglion cells, which are the pathological mechanisms of glaucoma. It also affects the risk of glaucoma development based on genetic pleomorphism. In addition, MMPs may affect the treatment outcomes of glaucoma, including the success rate of surgical treatment and side effects on the ocular surface due to glaucoma medications. This review discusses the various relationships between MMP and glaucoma.https://www.mdpi.com/2218-273X/12/10/1368glaucomamatrix metalloproteinasestrabecular meshworkocular surfacewound healinggenetics |
| spellingShingle | Moo Hyun Kim Su-Ho Lim Matrix Metalloproteinases and Glaucoma Biomolecules glaucoma matrix metalloproteinases trabecular meshwork ocular surface wound healing genetics |
| title | Matrix Metalloproteinases and Glaucoma |
| title_full | Matrix Metalloproteinases and Glaucoma |
| title_fullStr | Matrix Metalloproteinases and Glaucoma |
| title_full_unstemmed | Matrix Metalloproteinases and Glaucoma |
| title_short | Matrix Metalloproteinases and Glaucoma |
| title_sort | matrix metalloproteinases and glaucoma |
| topic | glaucoma matrix metalloproteinases trabecular meshwork ocular surface wound healing genetics |
| url | https://www.mdpi.com/2218-273X/12/10/1368 |
| work_keys_str_mv | AT moohyunkim matrixmetalloproteinasesandglaucoma AT suholim matrixmetalloproteinasesandglaucoma |