Studying the Effect of Amino Acid Substitutions in the M2 Ion Channel of the Influenza Virus on the Antiviral Activity of the Aminoadamantane Derivative In Vitro and In Silico

Studying the Effect of Amino Acid Substitutions in the M2 Ion Channel of the Influenza Virus on the Antiviral Activity of the Aminoadamantane Derivative In Vitro and In Silico

Purpose: The aminoadamantane derivative of L-histidyl-1-adamantayl ethylamine hydrochloride (HCl*H-His-Rim) has showed a high inhibition level against influenza A virus strains in vitro. The aim of this work is to search and establish evidence of the direct effect of the drug on influenza A virus pr...

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Main Authors: Timur Mansurovich Garaev, Artyom Irorevich Odnovorov, Alexander Aleksandrovich Lashkov, Tatiana Vladimirovna Grebennikova, Marina Pavlovna Finogenova, Galina Kadymovna Sadykova, Alexei Gennadievich Prilipov, Tatiana Anatol'evna Timofeeva, Sergey Vadimovich Rubinsky, Svetlana Nikolaevna Norkina, Marina Mikhailovna Zhuravleva
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2021-09-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
antiviral
drug resistance
influenza virus
m2 proton channel
molecular docking
reverse genetics
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-11-700.pdf

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