Targeted delivery of docetaxel to the metastatic lymph nodes: A comparison study between nanoliposomes and activated carbon nanoparticles
The objective of this study is to compare the targeting ability of activated carbon nanoparticles and nanoliposomes, which are used as carriers for delivering docetaxel (DTX) to the metastatic lymph nodes. In this study, we first prepared the DTX-loaded activated carbon nanoparticles (DTX-AC-NPs) by...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-02-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087614000543 |
| _version_ | 1819150576947036160 |
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| author | Tiantian Ye Wen Xu Tianyu Shi Rui Yang Xinggang Yang Shujun Wang Weisan Pan |
| author_facet | Tiantian Ye Wen Xu Tianyu Shi Rui Yang Xinggang Yang Shujun Wang Weisan Pan |
| author_sort | Tiantian Ye |
| collection | DOAJ |
| description | The objective of this study is to compare the targeting ability of activated carbon nanoparticles and nanoliposomes, which are used as carriers for delivering docetaxel (DTX) to the metastatic lymph nodes. In this study, we first prepared the DTX-loaded activated carbon nanoparticles (DTX-AC-NPs) by modifying the activated carbon with nitric acid oxidation and absorbing DTX in the concentrated nitro-oxide nanocarbon. We then prepared DTX-loaded nanoliposomes (DTX-LPs) by the proliposome method. The physiochemical properties of DTX-AC-NPs and DTX-LPs were carefully evaluated in vitro. The metastatic lymph node uptake and the injection site retention were investigated by analyzing the DTX concentration in metastatic lymph nodes and injection sites. The result showed that DTX-AC-NPs and DTX-LPs with suitable and stable physicochemical properties could be used for in vivo lymph node targeting studies. DTX-AC-NPs significantly increased DTX-AUC(0–24) and prolonged DTX-retention in metastatic lymph nodes compared to DTX-LPs and non-modified activate carbon in vivo. This study demonstrated activated carbon nanoparticles may be potential intralymphatic drug delivery system to preferentially target regional metastatic lymph nodes. |
| first_indexed | 2024-12-22T14:19:42Z |
| format | Article |
| id | doaj.art-707f1b3519834b53865ca8b2b3375673 |
| institution | Directory Open Access Journal |
| issn | 1818-0876 |
| language | English |
| last_indexed | 2024-12-22T14:19:42Z |
| publishDate | 2015-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-707f1b3519834b53865ca8b2b33756732022-12-21T18:23:01ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762015-02-01101647210.1016/j.ajps.2014.08.004Targeted delivery of docetaxel to the metastatic lymph nodes: A comparison study between nanoliposomes and activated carbon nanoparticlesTiantian Ye0Wen Xu1Tianyu Shi2Rui Yang3Xinggang Yang4Shujun Wang5Weisan Pan6Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, ChinaDepartment of R & D, Shenyang Green Pharmaceutical CO., LTD, 176 Shenbei Road, 110164, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, ChinaThe objective of this study is to compare the targeting ability of activated carbon nanoparticles and nanoliposomes, which are used as carriers for delivering docetaxel (DTX) to the metastatic lymph nodes. In this study, we first prepared the DTX-loaded activated carbon nanoparticles (DTX-AC-NPs) by modifying the activated carbon with nitric acid oxidation and absorbing DTX in the concentrated nitro-oxide nanocarbon. We then prepared DTX-loaded nanoliposomes (DTX-LPs) by the proliposome method. The physiochemical properties of DTX-AC-NPs and DTX-LPs were carefully evaluated in vitro. The metastatic lymph node uptake and the injection site retention were investigated by analyzing the DTX concentration in metastatic lymph nodes and injection sites. The result showed that DTX-AC-NPs and DTX-LPs with suitable and stable physicochemical properties could be used for in vivo lymph node targeting studies. DTX-AC-NPs significantly increased DTX-AUC(0–24) and prolonged DTX-retention in metastatic lymph nodes compared to DTX-LPs and non-modified activate carbon in vivo. This study demonstrated activated carbon nanoparticles may be potential intralymphatic drug delivery system to preferentially target regional metastatic lymph nodes.http://www.sciencedirect.com/science/article/pii/S1818087614000543Activated carbon nanoparticleNanoliposomeDocetaxelMetastatic lymph nodeLymph node targeting |
| spellingShingle | Tiantian Ye Wen Xu Tianyu Shi Rui Yang Xinggang Yang Shujun Wang Weisan Pan Targeted delivery of docetaxel to the metastatic lymph nodes: A comparison study between nanoliposomes and activated carbon nanoparticles Asian Journal of Pharmaceutical Sciences Activated carbon nanoparticle Nanoliposome Docetaxel Metastatic lymph node Lymph node targeting |
| title | Targeted delivery of docetaxel to the metastatic lymph nodes: A comparison study between nanoliposomes and activated carbon nanoparticles |
| title_full | Targeted delivery of docetaxel to the metastatic lymph nodes: A comparison study between nanoliposomes and activated carbon nanoparticles |
| title_fullStr | Targeted delivery of docetaxel to the metastatic lymph nodes: A comparison study between nanoliposomes and activated carbon nanoparticles |
| title_full_unstemmed | Targeted delivery of docetaxel to the metastatic lymph nodes: A comparison study between nanoliposomes and activated carbon nanoparticles |
| title_short | Targeted delivery of docetaxel to the metastatic lymph nodes: A comparison study between nanoliposomes and activated carbon nanoparticles |
| title_sort | targeted delivery of docetaxel to the metastatic lymph nodes a comparison study between nanoliposomes and activated carbon nanoparticles |
| topic | Activated carbon nanoparticle Nanoliposome Docetaxel Metastatic lymph node Lymph node targeting |
| url | http://www.sciencedirect.com/science/article/pii/S1818087614000543 |
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