Comprehensive analysis of ADGRE5 gene in human tumors: Clinical relevance, prognostic implications, and potential for personalized immunotherapy
Purpose: The Adhesion G protein receptor E5 (ADGRE5) gene is involved in a wide range of biological functions in human tumors; however, its specific molecular mechanism and significance in the analysis of human tumors have not yet been determined. Here, we provide a comprehensive genomic architectur...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402403490X |
| _version_ | 1797224269994786816 |
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| author | Xiangjian Zhang Xinxin Zhang Qiuhui Yang Ruokuo Han Walaa Fadhul Alisha Sachdeva Xianbo Zhang |
| author_facet | Xiangjian Zhang Xinxin Zhang Qiuhui Yang Ruokuo Han Walaa Fadhul Alisha Sachdeva Xianbo Zhang |
| author_sort | Xiangjian Zhang |
| collection | DOAJ |
| description | Purpose: The Adhesion G protein receptor E5 (ADGRE5) gene is involved in a wide range of biological functions in human tumors; however, its specific molecular mechanism and significance in the analysis of human tumors have not yet been determined. Here, we provide a comprehensive genomic architecture of ADGRE5 in the tumor immune microenvironment and its clinical relevance across a broad range of solid tumors. Methods: In this study, we used publicly available bioinformatics databases, with a primary focus on The Cancer Genome Atlas (TCGA) database and GTEx data, to conduct a comprehensive analysis of the impact on patient prognosis associated with ADGRE5. Results: Statistics of more than 30 solid tumors from TCGA and Cancer Cell Line Encyclopedia (CCLE) were examined. ADGRE5 was differentially expressed in several cancers and was significantly associated with survival outcomes. Higher ADGRE5 levels were associated with worse prognosis in adrenocortical carcinoma, low grade glioma of the brain (LGG), lung squamous cell carcinoma, liver hepatocellular carcinoma, and uveal melanoma (UVM). Additionally, ADGRE5 was found to be an independent risk factor for LGG and UVM. The clinical relevance of ADGRE5 in tumor immunogenicity was further investigated. The expression level of ADGRE5 was not only strongly associated with tumor infiltration, such as tumor-infiltrating immune cells and immune subtypes, but also with tumor mutation burden, pyroptosis, and epithelial-mesenchymal transition in various types of cancer (P < 0.05). Furthermore, we noted that ADGRE5 exhibited a positive association with targeted drug sensitivity and conversely, a negative association with traditional chemotherapeutic drug sensitivity. Thus, ADGRE5 is expected to be a guiding marker gene for clinical prognosis and personalized tumor immunotherapy. |
| first_indexed | 2024-04-24T13:50:27Z |
| format | Article |
| id | doaj.art-7080d6dcc6d946c7b49f10e57c71c6c9 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T13:50:27Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-7080d6dcc6d946c7b49f10e57c71c6c92024-04-04T05:04:53ZengElsevierHeliyon2405-84402024-03-01106e27459Comprehensive analysis of ADGRE5 gene in human tumors: Clinical relevance, prognostic implications, and potential for personalized immunotherapyXiangjian Zhang0Xinxin Zhang1Qiuhui Yang2Ruokuo Han3Walaa Fadhul4Alisha Sachdeva5Xianbo Zhang6Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, ChinaWenzhou Medical University, Wenzhou, Zhejiang, 325035, ChinaDepartment of Surgical Oncology, Wenzhou Central Hospital, Wenzhou, Zhejiang, 325000, ChinaWenzhou Medical University, Wenzhou, Zhejiang, 325035, ChinaWenzhou Medical University, Wenzhou, Zhejiang, 325035, ChinaDepartment of Surgical Oncology, Wenzhou Central Hospital, Wenzhou, Zhejiang, 325000, China; Corresponding author.Purpose: The Adhesion G protein receptor E5 (ADGRE5) gene is involved in a wide range of biological functions in human tumors; however, its specific molecular mechanism and significance in the analysis of human tumors have not yet been determined. Here, we provide a comprehensive genomic architecture of ADGRE5 in the tumor immune microenvironment and its clinical relevance across a broad range of solid tumors. Methods: In this study, we used publicly available bioinformatics databases, with a primary focus on The Cancer Genome Atlas (TCGA) database and GTEx data, to conduct a comprehensive analysis of the impact on patient prognosis associated with ADGRE5. Results: Statistics of more than 30 solid tumors from TCGA and Cancer Cell Line Encyclopedia (CCLE) were examined. ADGRE5 was differentially expressed in several cancers and was significantly associated with survival outcomes. Higher ADGRE5 levels were associated with worse prognosis in adrenocortical carcinoma, low grade glioma of the brain (LGG), lung squamous cell carcinoma, liver hepatocellular carcinoma, and uveal melanoma (UVM). Additionally, ADGRE5 was found to be an independent risk factor for LGG and UVM. The clinical relevance of ADGRE5 in tumor immunogenicity was further investigated. The expression level of ADGRE5 was not only strongly associated with tumor infiltration, such as tumor-infiltrating immune cells and immune subtypes, but also with tumor mutation burden, pyroptosis, and epithelial-mesenchymal transition in various types of cancer (P < 0.05). Furthermore, we noted that ADGRE5 exhibited a positive association with targeted drug sensitivity and conversely, a negative association with traditional chemotherapeutic drug sensitivity. Thus, ADGRE5 is expected to be a guiding marker gene for clinical prognosis and personalized tumor immunotherapy.http://www.sciencedirect.com/science/article/pii/S240584402403490XPan-cancerPrognostic bio-makerADGRE5Immune infiltrationTumor mutation burdenPyroptosis |
| spellingShingle | Xiangjian Zhang Xinxin Zhang Qiuhui Yang Ruokuo Han Walaa Fadhul Alisha Sachdeva Xianbo Zhang Comprehensive analysis of ADGRE5 gene in human tumors: Clinical relevance, prognostic implications, and potential for personalized immunotherapy Heliyon Pan-cancer Prognostic bio-maker ADGRE5 Immune infiltration Tumor mutation burden Pyroptosis |
| title | Comprehensive analysis of ADGRE5 gene in human tumors: Clinical relevance, prognostic implications, and potential for personalized immunotherapy |
| title_full | Comprehensive analysis of ADGRE5 gene in human tumors: Clinical relevance, prognostic implications, and potential for personalized immunotherapy |
| title_fullStr | Comprehensive analysis of ADGRE5 gene in human tumors: Clinical relevance, prognostic implications, and potential for personalized immunotherapy |
| title_full_unstemmed | Comprehensive analysis of ADGRE5 gene in human tumors: Clinical relevance, prognostic implications, and potential for personalized immunotherapy |
| title_short | Comprehensive analysis of ADGRE5 gene in human tumors: Clinical relevance, prognostic implications, and potential for personalized immunotherapy |
| title_sort | comprehensive analysis of adgre5 gene in human tumors clinical relevance prognostic implications and potential for personalized immunotherapy |
| topic | Pan-cancer Prognostic bio-maker ADGRE5 Immune infiltration Tumor mutation burden Pyroptosis |
| url | http://www.sciencedirect.com/science/article/pii/S240584402403490X |
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