Impact of Blood-Count-Derived Inflammatory Markers in Psoriatic Disease Progression
Psoriasis is a chronic immune-mediated disease, linked to local and systemic inflammation and predisposing patients to a higher risk of associated comorbidities. Cytokine levels are not widely available for disease progression monitoring due to high costs. Validated low-cost and reliable markers are...
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MDPI AG
2024-01-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/14/1/114 |
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| author | Oana Mirela Tiucă Silviu Horia Morariu Claudia Raluca Mariean Robert Aurelian Tiucă Alin Codrut Nicolescu Ovidiu Simion Cotoi |
| author_facet | Oana Mirela Tiucă Silviu Horia Morariu Claudia Raluca Mariean Robert Aurelian Tiucă Alin Codrut Nicolescu Ovidiu Simion Cotoi |
| author_sort | Oana Mirela Tiucă |
| collection | DOAJ |
| description | Psoriasis is a chronic immune-mediated disease, linked to local and systemic inflammation and predisposing patients to a higher risk of associated comorbidities. Cytokine levels are not widely available for disease progression monitoring due to high costs. Validated low-cost and reliable markers are needed for assessing disease progression and outcome. This study aims to assess the reliability of blood-count-derived inflammatory markers as disease predictors and to identify prognostic factors for disease severity. Patients fulfilling the inclusion criteria were enrolled in this study. Patients were divided into three study groups according to disease severity measured by the Body Surface Area (BSA) score: mild, moderate, and severe psoriasis. White blood cell count (WBC), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), derived neutrophil-to-lymphocyte ratio (d-NLR), systemic immune index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI) positively were correlated with disease severity (<i>p</i> < 0.005). d-NLR, NLR, and SII are independent prognostic factors for mild and moderate psoriasis (<i>p</i> < 0.05). d-NLR is the only independent prognostic factor for all three study groups. Moderate psoriasis is defined by d-NLR values between 1.49 and 2.19. NLR, PLR, d-NLR, MLR, SII, SIRI, and AISI are useful indicators of systemic inflammation and disease severity in psoriasis. |
| first_indexed | 2024-03-08T10:44:24Z |
| format | Article |
| id | doaj.art-7081619299534dcca665659138cde906 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-08T10:44:24Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-7081619299534dcca665659138cde9062024-01-26T17:21:04ZengMDPI AGLife2075-17292024-01-0114111410.3390/life14010114Impact of Blood-Count-Derived Inflammatory Markers in Psoriatic Disease ProgressionOana Mirela Tiucă0Silviu Horia Morariu1Claudia Raluca Mariean2Robert Aurelian Tiucă3Alin Codrut Nicolescu4Ovidiu Simion Cotoi5Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, RomaniaDermatology Department, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, RomaniaDoctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, RomaniaDoctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, RomaniaAgrippa Ionescu Emergency Clinical Hospital, 011773 Bucharest, RomaniaPathophysiology Department, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, RomaniaPsoriasis is a chronic immune-mediated disease, linked to local and systemic inflammation and predisposing patients to a higher risk of associated comorbidities. Cytokine levels are not widely available for disease progression monitoring due to high costs. Validated low-cost and reliable markers are needed for assessing disease progression and outcome. This study aims to assess the reliability of blood-count-derived inflammatory markers as disease predictors and to identify prognostic factors for disease severity. Patients fulfilling the inclusion criteria were enrolled in this study. Patients were divided into three study groups according to disease severity measured by the Body Surface Area (BSA) score: mild, moderate, and severe psoriasis. White blood cell count (WBC), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), derived neutrophil-to-lymphocyte ratio (d-NLR), systemic immune index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI) positively were correlated with disease severity (<i>p</i> < 0.005). d-NLR, NLR, and SII are independent prognostic factors for mild and moderate psoriasis (<i>p</i> < 0.05). d-NLR is the only independent prognostic factor for all three study groups. Moderate psoriasis is defined by d-NLR values between 1.49 and 2.19. NLR, PLR, d-NLR, MLR, SII, SIRI, and AISI are useful indicators of systemic inflammation and disease severity in psoriasis.https://www.mdpi.com/2075-1729/14/1/114psoriasisinflammationdisease severityblood markersinflammatory skin diseases |
| spellingShingle | Oana Mirela Tiucă Silviu Horia Morariu Claudia Raluca Mariean Robert Aurelian Tiucă Alin Codrut Nicolescu Ovidiu Simion Cotoi Impact of Blood-Count-Derived Inflammatory Markers in Psoriatic Disease Progression Life psoriasis inflammation disease severity blood markers inflammatory skin diseases |
| title | Impact of Blood-Count-Derived Inflammatory Markers in Psoriatic Disease Progression |
| title_full | Impact of Blood-Count-Derived Inflammatory Markers in Psoriatic Disease Progression |
| title_fullStr | Impact of Blood-Count-Derived Inflammatory Markers in Psoriatic Disease Progression |
| title_full_unstemmed | Impact of Blood-Count-Derived Inflammatory Markers in Psoriatic Disease Progression |
| title_short | Impact of Blood-Count-Derived Inflammatory Markers in Psoriatic Disease Progression |
| title_sort | impact of blood count derived inflammatory markers in psoriatic disease progression |
| topic | psoriasis inflammation disease severity blood markers inflammatory skin diseases |
| url | https://www.mdpi.com/2075-1729/14/1/114 |
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