The role of transducin β-like 1 X-linked receptor 1 (TBL1XR1) in thyroid hormone metabolism and action in mice

The role of transducin β-like 1 X-linked receptor 1 (TBL1XR1) in thyroid hormone metabolism and action in mice

Transducin β-like 1 X-linked receptor 1 (TBL1XR1) is a WD40 repeat-containing protein and part of the corepressor complex SMRT/NCoR that binds to the thyroid hormone receptor (TR). We recently described a mutation in TBL1XR1 in patients with Pierpont syndrome. A mouse model bearing this Tbl1xr1 muta...

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Bibliographic Details
Main Authors: Yalan Hu, Kim Falize, A S Paul van Trotsenburg, Raoul Hennekam, Eric Fliers, Eveline Bruinstroop, Anita Boelen
Format: Article
Language:English
Published: Bioscientifica 2023-08-01
Series:European Thyroid Journal
Subjects:
thyroid hormone
tbl1xr1
co-repressor complex
thyroid hormone action
Online Access:https://etj.bioscientifica.com/view/journals/etj/12/5/ETJ-23-0077.xml

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