A Single Chain Fragment Variant Binding Misfolded Alpha-Synuclein Exhibits Neuroprotective and Antigen-Specific Anti-Inflammatory Properties

A Single Chain Fragment Variant Binding Misfolded Alpha-Synuclein Exhibits Neuroprotective and Antigen-Specific Anti-Inflammatory Properties

Introduction. Alpha synuclein (αSyn) misfolding plays a requisite role in the pathogenesis of synucleinopathies. Direct toxicity to neurons, triggering neuroinflammation as well as the spreading and seeding of αSyn pathology are essential pathogenetic underlying mechanisms. Immunotherapy in experime...

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Bibliographic Details
Main Authors: Michael Fassler, Clara Benaim, Jacob George
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
synucleinopathies
immunotherapy
alpha synuclein
neurodegeneration
nose to brain delivery
Online Access:https://www.mdpi.com/2073-4409/11/23/3822

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