Coding Variants Coupled With Rapid Modeling in Zebrafish Implicate Dynein Genes, dnaaf1 and zmynd10, as Adolescent Idiopathic Scoliosis Candidate Genes

Coding Variants Coupled With Rapid Modeling in Zebrafish Implicate Dynein Genes, dnaaf1 and zmynd10, as Adolescent Idiopathic Scoliosis Candidate Genes

Adolescent idiopathic scoliosis (AIS) is the most common pediatric spine disorder affecting ∼3% of children worldwide. Human genetic studies suggest a complex polygenic disease model for AIS with large genetic and phenotypic heterogeneity. However, the overall genetic etiology of AIS remains poorly...

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Bibliographic Details
Main Authors:	Yunjia Wang, Zhenhao Liu, Guanteng Yang, Qile Gao, Lige Xiao, Jiong Li, Chaofeng Guo, Benjamin R. Troutwine, Ryan S. Gray, Lu Xie, Hongqi Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-11-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	adolescent idiopathic scoliosis whole exome sequencing southern Chinese population genetic variations bioinformatics analysis gene knockout
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2020.582255/full

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