3D Bioprinting of Smart Oxygen-Releasing Cartilage Scaffolds
Three-dimensional bioprinting is a powerful technique for manufacturing improved engineered tissues. Three-dimensional bioprinted hydrogels have significantly advanced the medical field to repair cartilage tissue, allowing for such constructs to be loaded with different components, such as cells, na...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/13/4/252 |
| _version_ | 1797456998180061184 |
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| author | Caterine Yesenia Carrasco Montesdeoca Thiago Domingues Stocco Fernanda Roberta Marciano Thomas J. Webster Anderson Oliveira Lobo |
| author_facet | Caterine Yesenia Carrasco Montesdeoca Thiago Domingues Stocco Fernanda Roberta Marciano Thomas J. Webster Anderson Oliveira Lobo |
| author_sort | Caterine Yesenia Carrasco Montesdeoca |
| collection | DOAJ |
| description | Three-dimensional bioprinting is a powerful technique for manufacturing improved engineered tissues. Three-dimensional bioprinted hydrogels have significantly advanced the medical field to repair cartilage tissue, allowing for such constructs to be loaded with different components, such as cells, nanoparticles, and/or drugs. Cartilage, as an avascular tissue, presents extreme difficulty in self-repair when it has been damaged. In this way, hydrogels with optimal chemical and physical properties have been researched to respond to external stimuli and release various bioactive agents to further promote a desired tissue response. For instance, methacryloyl gelatin (GelMA) is a type of modified hydrogel that allows for the encapsulation of cells, as well as oxygen-releasing nanoparticles that, in the presence of an aqueous medium and through controlled porosity and swelling, allow for internal and external environmental exchanges. This review explores the 3D bioprinting of hydrogels, with a particular focus on GelMA hydrogels, to repair cartilage tissue. Recent advances and future perspectives are described. |
| first_indexed | 2024-03-09T16:15:50Z |
| format | Article |
| id | doaj.art-70831151cb9845869d4e813de699e9f2 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T16:15:50Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-70831151cb9845869d4e813de699e9f22023-11-24T15:50:15ZengMDPI AGJournal of Functional Biomaterials2079-49832022-11-0113425210.3390/jfb130402523D Bioprinting of Smart Oxygen-Releasing Cartilage ScaffoldsCaterine Yesenia Carrasco Montesdeoca0Thiago Domingues Stocco1Fernanda Roberta Marciano2Thomas J. Webster3Anderson Oliveira Lobo4Faculty of Medical Science, State University of Campinas, Campinas 13083-872, SP, BrazilBioengineering Program, Scientific and Technological Institute, Brasil University, São Paulo 13566-590, SP, BrazilDepartment of Physics, UFPI—Federal University of Piaui, Teresina 64049-550, PI, BrazilInterdisciplinary Laboratory for Advanced Materials (LIMAV), Materials Science and Engineering Graduate Program (PPGCM), Federal University of Piaui (UFPI), Teresina 64049-550, PI, BrazilInterdisciplinary Laboratory for Advanced Materials (LIMAV), Materials Science and Engineering Graduate Program (PPGCM), Federal University of Piaui (UFPI), Teresina 64049-550, PI, BrazilThree-dimensional bioprinting is a powerful technique for manufacturing improved engineered tissues. Three-dimensional bioprinted hydrogels have significantly advanced the medical field to repair cartilage tissue, allowing for such constructs to be loaded with different components, such as cells, nanoparticles, and/or drugs. Cartilage, as an avascular tissue, presents extreme difficulty in self-repair when it has been damaged. In this way, hydrogels with optimal chemical and physical properties have been researched to respond to external stimuli and release various bioactive agents to further promote a desired tissue response. For instance, methacryloyl gelatin (GelMA) is a type of modified hydrogel that allows for the encapsulation of cells, as well as oxygen-releasing nanoparticles that, in the presence of an aqueous medium and through controlled porosity and swelling, allow for internal and external environmental exchanges. This review explores the 3D bioprinting of hydrogels, with a particular focus on GelMA hydrogels, to repair cartilage tissue. Recent advances and future perspectives are described.https://www.mdpi.com/2079-4983/13/4/2523D bioprintingsmart biomaterialscartilage tissue regenerationgelatin methacryloyl (GelMA)oxygen-releasing nanoparticles |
| spellingShingle | Caterine Yesenia Carrasco Montesdeoca Thiago Domingues Stocco Fernanda Roberta Marciano Thomas J. Webster Anderson Oliveira Lobo 3D Bioprinting of Smart Oxygen-Releasing Cartilage Scaffolds Journal of Functional Biomaterials 3D bioprinting smart biomaterials cartilage tissue regeneration gelatin methacryloyl (GelMA) oxygen-releasing nanoparticles |
| title | 3D Bioprinting of Smart Oxygen-Releasing Cartilage Scaffolds |
| title_full | 3D Bioprinting of Smart Oxygen-Releasing Cartilage Scaffolds |
| title_fullStr | 3D Bioprinting of Smart Oxygen-Releasing Cartilage Scaffolds |
| title_full_unstemmed | 3D Bioprinting of Smart Oxygen-Releasing Cartilage Scaffolds |
| title_short | 3D Bioprinting of Smart Oxygen-Releasing Cartilage Scaffolds |
| title_sort | 3d bioprinting of smart oxygen releasing cartilage scaffolds |
| topic | 3D bioprinting smart biomaterials cartilage tissue regeneration gelatin methacryloyl (GelMA) oxygen-releasing nanoparticles |
| url | https://www.mdpi.com/2079-4983/13/4/252 |
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