Verification of P-Glycoprotein Function at the Dermal Barrier in Diffusion Cells and Dynamic “Skin-On-A-Chip” Microfluidic Device

Verification of P-Glycoprotein Function at the Dermal Barrier in Diffusion Cells and Dynamic “Skin-On-A-Chip” Microfluidic Device

The efficacy of transdermal absorption of drugs and the irritation or corrosion potential of topically applied formulations are important areas of investigation in pharmaceutical, military and cosmetic research. The aim of the present experiments is to test the role of P-glycoprotein in dermal drug...

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Bibliographic Details
Main Authors: Ágnes Bajza, Dorottya Kocsis, Orsolya Berezvai, András József Laki, Bence Lukács, Tímea Imre, Kristóf Iván, Pál Szabó, Franciska Erdő
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Pharmaceutics
Subjects:
P-glycoprotein
skin-on-a-chip
microfluidic device
Franz diffusion cell
skin permeability
transdermal microdialysis
Online Access:https://www.mdpi.com/1999-4923/12/9/804

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