Diabetes mellitus degenerates cisplatin-induced nephrotoxicity in short hydration method: a propensity score-matching analysis
Abstract Cisplatin (CDDP)-induced nephrotoxicity (CIN) is dose-limiting. We revealed that co-administration of non-steroid anti-inflammatory drugs and baseline comorbidity of diabetes mellitus (DM) are associated with CIN development in the short hydration method; however, the results were accessori...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-26454-x |
| _version_ | 1811292485907906560 |
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| author | Yoshitaka Saito Tatsuhiko Sakamoto Yoh Takekuma Masaki Kobayashi Keisuke Okamoto Naofumi Shinagawa Yasushi Shimizu Ichiro Kinoshita Mitsuru Sugawara |
| author_facet | Yoshitaka Saito Tatsuhiko Sakamoto Yoh Takekuma Masaki Kobayashi Keisuke Okamoto Naofumi Shinagawa Yasushi Shimizu Ichiro Kinoshita Mitsuru Sugawara |
| author_sort | Yoshitaka Saito |
| collection | DOAJ |
| description | Abstract Cisplatin (CDDP)-induced nephrotoxicity (CIN) is dose-limiting. We revealed that co-administration of non-steroid anti-inflammatory drugs and baseline comorbidity of diabetes mellitus (DM) are associated with CIN development in the short hydration method; however, the results were accessorily obtained without appropriate power calculation. This study aimed to demonstrate the influence of DM complications on CIN incidence in a real-world setting. Lung cancer patients receiving CDDP (≥ 75 mg/m2)-containing regimens with a short hydration method (n = 227) were retrospectively evaluated. The patients were divided into control and baseline DM complication groups. The primary endpoint was the evaluation of CIN incidence between the groups. Propensity score-matching was performed to confirm the robustness of the primary analysis results. CIN occurred in 6.8% of control and 27.0% of DM patients, respectively, with a significant difference in all-patient populations (P = 0.001). In addition, variation of serum creatinine and creatinine clearance significantly worsened in DM patients. Similar results were obtained in a propensity-matched population. Multivariate logistic regression analysis found that DM complication is a singular risk factor for CIN development (adjusted odds ratio; 4.31, 95% confidence interval; 1.62–11.50, P = 0.003). In conclusion, our study revealed that baseline DM complications significantly worsen CIN. |
| first_indexed | 2024-04-13T04:46:01Z |
| format | Article |
| id | doaj.art-70846336ceab43d289c7ca2a35418364 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T04:46:01Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-70846336ceab43d289c7ca2a354183642022-12-22T03:01:51ZengNature PortfolioScientific Reports2045-23222022-12-011211810.1038/s41598-022-26454-xDiabetes mellitus degenerates cisplatin-induced nephrotoxicity in short hydration method: a propensity score-matching analysisYoshitaka Saito0Tatsuhiko Sakamoto1Yoh Takekuma2Masaki Kobayashi3Keisuke Okamoto4Naofumi Shinagawa5Yasushi Shimizu6Ichiro Kinoshita7Mitsuru Sugawara8Department of Pharmacy, Hokkaido University HospitalDepartment of Pharmacy, Hokkaido University HospitalDepartment of Pharmacy, Hokkaido University HospitalLaboratory of Clinical Pharmaceutics & Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido UniversityDepartment of Pharmacy, Hokkaido University HospitalDepartment of Respiratory Medicine, Faculty of Medicine, Hokkaido UniversityDepartment of Medical Oncology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Medical Oncology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Pharmacy, Hokkaido University HospitalAbstract Cisplatin (CDDP)-induced nephrotoxicity (CIN) is dose-limiting. We revealed that co-administration of non-steroid anti-inflammatory drugs and baseline comorbidity of diabetes mellitus (DM) are associated with CIN development in the short hydration method; however, the results were accessorily obtained without appropriate power calculation. This study aimed to demonstrate the influence of DM complications on CIN incidence in a real-world setting. Lung cancer patients receiving CDDP (≥ 75 mg/m2)-containing regimens with a short hydration method (n = 227) were retrospectively evaluated. The patients were divided into control and baseline DM complication groups. The primary endpoint was the evaluation of CIN incidence between the groups. Propensity score-matching was performed to confirm the robustness of the primary analysis results. CIN occurred in 6.8% of control and 27.0% of DM patients, respectively, with a significant difference in all-patient populations (P = 0.001). In addition, variation of serum creatinine and creatinine clearance significantly worsened in DM patients. Similar results were obtained in a propensity-matched population. Multivariate logistic regression analysis found that DM complication is a singular risk factor for CIN development (adjusted odds ratio; 4.31, 95% confidence interval; 1.62–11.50, P = 0.003). In conclusion, our study revealed that baseline DM complications significantly worsen CIN.https://doi.org/10.1038/s41598-022-26454-x |
| spellingShingle | Yoshitaka Saito Tatsuhiko Sakamoto Yoh Takekuma Masaki Kobayashi Keisuke Okamoto Naofumi Shinagawa Yasushi Shimizu Ichiro Kinoshita Mitsuru Sugawara Diabetes mellitus degenerates cisplatin-induced nephrotoxicity in short hydration method: a propensity score-matching analysis Scientific Reports |
| title | Diabetes mellitus degenerates cisplatin-induced nephrotoxicity in short hydration method: a propensity score-matching analysis |
| title_full | Diabetes mellitus degenerates cisplatin-induced nephrotoxicity in short hydration method: a propensity score-matching analysis |
| title_fullStr | Diabetes mellitus degenerates cisplatin-induced nephrotoxicity in short hydration method: a propensity score-matching analysis |
| title_full_unstemmed | Diabetes mellitus degenerates cisplatin-induced nephrotoxicity in short hydration method: a propensity score-matching analysis |
| title_short | Diabetes mellitus degenerates cisplatin-induced nephrotoxicity in short hydration method: a propensity score-matching analysis |
| title_sort | diabetes mellitus degenerates cisplatin induced nephrotoxicity in short hydration method a propensity score matching analysis |
| url | https://doi.org/10.1038/s41598-022-26454-x |
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