Gata3ZsG and Gata3ZsG-fl: Novel murine Gata3 reporter alleles for identifying and studying Th2 cells and ILC2s in vivo

Gata3ZsG and Gata3ZsG-fl: Novel murine Gata3 reporter alleles for identifying and studying Th2 cells and ILC2s in vivo

T helper-2 (Th2) cells and type 2 innate lymphoid cells (ILC2s) play crucial roles during type 2 immune responses; the transcription factor GATA3 is essential for the differentiation and functions of these cell types. It has been demonstrated that GATA3 is critical for maintaining Th2 and ILC2 pheno...

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Bibliographic Details
Main Authors: Rama K. Gurram, Danping Wei, Qiao Yu, Olena Kamenyeva, Hyunwoo Chung, Mingzhu Zheng, Matthew J. Butcher, Juraj Kabat, Chengyu Liu, Jaspal S. Khillan, Jinfang Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
GATA3
type 2 innate lymphoid cells
T helper cell 2
reporter mouse model
gene regulation
in vivo
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.975958/full

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