Relationship of hypoglycemia and glucose variability with autonomic dysfunction in children and adolescents with type 1 diabetes
Aim. Glucose variability (GV) and hypoglycaemia frequency and duration, depending on cardiovascular autonomic dysfunction, in children and adolescents with type 1 diabetes mellitus (T1DM) were evaluated. Materials and methods. One hundred and thirty T1DM patients, aged 6?18 years, were included in...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2014-12-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/6699 |
| _version_ | 1797255212035997696 |
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| author | Dmitriy Nikitich Laptev |
| author_facet | Dmitriy Nikitich Laptev |
| author_sort | Dmitriy Nikitich Laptev |
| collection | DOAJ |
| description | Aim. Glucose variability (GV) and hypoglycaemia frequency and duration, depending on cardiovascular autonomic dysfunction, in children and adolescents with type 1 diabetes mellitus (T1DM) were evaluated. Materials and methods. One hundred and thirty T1DM patients, aged 6?18 years, were included in this study. The study included 3 tests:. continuous glucose monitoring (CGM) with GV evaluation, frequency and duration of hypoglycaemia;24-h ECG monitoring with automatic calculation of QTc interval and heart rate variability (HRV) parameters;cardiovascular autonomic tests.Results. The estimated prevalence of cardiovascular autonomic neuropathy (CAN) was 19.2%. CAN positive (CAN+) patients had lower values from cardiovascular autonomic tests and HRV and longer QTc intervals compared with CAN negative (CAN-) patients (p |
| first_indexed | 2024-03-08T15:21:20Z |
| format | Article |
| id | doaj.art-708712bc7f594ddb8dca8532d9dd506f |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:02:15Z |
| publishDate | 2014-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-708712bc7f594ddb8dca8532d9dd506f2024-03-20T11:47:59ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782014-12-01174879210.14341/DM2014487-926501Relationship of hypoglycemia and glucose variability with autonomic dysfunction in children and adolescents with type 1 diabetesDmitriy Nikitich Laptev0Endocrinology Research Centre, MoscowAim. Glucose variability (GV) and hypoglycaemia frequency and duration, depending on cardiovascular autonomic dysfunction, in children and adolescents with type 1 diabetes mellitus (T1DM) were evaluated. Materials and methods. One hundred and thirty T1DM patients, aged 6?18 years, were included in this study. The study included 3 tests:. continuous glucose monitoring (CGM) with GV evaluation, frequency and duration of hypoglycaemia;24-h ECG monitoring with automatic calculation of QTc interval and heart rate variability (HRV) parameters;cardiovascular autonomic tests.Results. The estimated prevalence of cardiovascular autonomic neuropathy (CAN) was 19.2%. CAN positive (CAN+) patients had lower values from cardiovascular autonomic tests and HRV and longer QTc intervals compared with CAN negative (CAN-) patients (phttps://www.dia-endojournals.ru/jour/article/view/6699type 1 diabetes mellitus, autonomic neuropathy, heart rate variability, hypoglycaemia, glucose variability, qt interval |
| spellingShingle | Dmitriy Nikitich Laptev Relationship of hypoglycemia and glucose variability with autonomic dysfunction in children and adolescents with type 1 diabetes Сахарный диабет type 1 diabetes mellitus, autonomic neuropathy, heart rate variability, hypoglycaemia, glucose variability, qt interval |
| title | Relationship of hypoglycemia and glucose variability with autonomic dysfunction in children and adolescents with type 1 diabetes |
| title_full | Relationship of hypoglycemia and glucose variability with autonomic dysfunction in children and adolescents with type 1 diabetes |
| title_fullStr | Relationship of hypoglycemia and glucose variability with autonomic dysfunction in children and adolescents with type 1 diabetes |
| title_full_unstemmed | Relationship of hypoglycemia and glucose variability with autonomic dysfunction in children and adolescents with type 1 diabetes |
| title_short | Relationship of hypoglycemia and glucose variability with autonomic dysfunction in children and adolescents with type 1 diabetes |
| title_sort | relationship of hypoglycemia and glucose variability with autonomic dysfunction in children and adolescents with type 1 diabetes |
| topic | type 1 diabetes mellitus, autonomic neuropathy, heart rate variability, hypoglycaemia, glucose variability, qt interval |
| url | https://www.dia-endojournals.ru/jour/article/view/6699 |
| work_keys_str_mv | AT dmitriynikitichlaptev relationshipofhypoglycemiaandglucosevariabilitywithautonomicdysfunctioninchildrenandadolescentswithtype1diabetes |