The Use of Yeast in Biosensing
Yeast has been used as a model for several diseases as it is the simplest unicellular eukaryote, safe and easy to culture and harbors most of the fundamental processes that are present in almost all higher eukaryotes, including humans. From understanding the pathogenesis of disease to drug discovery...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/10/9/1772 |
| _version_ | 1797484545672478720 |
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| author | Sudip Dhakal Ian Macreadie |
| author_facet | Sudip Dhakal Ian Macreadie |
| author_sort | Sudip Dhakal |
| collection | DOAJ |
| description | Yeast has been used as a model for several diseases as it is the simplest unicellular eukaryote, safe and easy to culture and harbors most of the fundamental processes that are present in almost all higher eukaryotes, including humans. From understanding the pathogenesis of disease to drug discovery studies, yeast has served as an important biosensor. It is not only due to the conservation of genetics, amenable modification of its genome and easily accessible analytical methods, but also some characteristic features such as its ability to survive with defective mitochondria, making it a highly flexible microbe for designing whole-cell biosensing systems. The aim of this review is to report on how yeasts have been utilized as biosensors, reporting on responses to various stimuli. |
| first_indexed | 2024-03-09T23:05:54Z |
| format | Article |
| id | doaj.art-70878331e4be4acb8e5ea79f015d9c40 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T23:05:54Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-70878331e4be4acb8e5ea79f015d9c402023-11-23T17:52:59ZengMDPI AGMicroorganisms2076-26072022-09-01109177210.3390/microorganisms10091772The Use of Yeast in BiosensingSudip Dhakal0Ian Macreadie1School of Science, RMIT University, Bundoora, VIC 3083, AustraliaSchool of Science, RMIT University, Bundoora, VIC 3083, AustraliaYeast has been used as a model for several diseases as it is the simplest unicellular eukaryote, safe and easy to culture and harbors most of the fundamental processes that are present in almost all higher eukaryotes, including humans. From understanding the pathogenesis of disease to drug discovery studies, yeast has served as an important biosensor. It is not only due to the conservation of genetics, amenable modification of its genome and easily accessible analytical methods, but also some characteristic features such as its ability to survive with defective mitochondria, making it a highly flexible microbe for designing whole-cell biosensing systems. The aim of this review is to report on how yeasts have been utilized as biosensors, reporting on responses to various stimuli.https://www.mdpi.com/2076-2607/10/9/1772biosensoryeastyeast two-hybridyeast surface displayFRETfluorescent proteins |
| spellingShingle | Sudip Dhakal Ian Macreadie The Use of Yeast in Biosensing Microorganisms biosensor yeast yeast two-hybrid yeast surface display FRET fluorescent proteins |
| title | The Use of Yeast in Biosensing |
| title_full | The Use of Yeast in Biosensing |
| title_fullStr | The Use of Yeast in Biosensing |
| title_full_unstemmed | The Use of Yeast in Biosensing |
| title_short | The Use of Yeast in Biosensing |
| title_sort | use of yeast in biosensing |
| topic | biosensor yeast yeast two-hybrid yeast surface display FRET fluorescent proteins |
| url | https://www.mdpi.com/2076-2607/10/9/1772 |
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