Spontaneous apoptosis of lymphocytes of ovary cancer patients
Results of the study of the spontaneous apoptosis mechanisms of peripheral blood lymphocytes of ovary cancer (OC) patients are presented in the article. Dynamics of mitochondrial potential (MP) change, level of phosphatidylserine (PS) expression and DNA fragmentation were used as apoptosis markers....
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2007-06-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/3243 |
| _version_ | 1827991940002480128 |
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| author | I. I. Antoneyeva S. V. Boichuk |
| author_facet | I. I. Antoneyeva S. V. Boichuk |
| author_sort | I. I. Antoneyeva |
| collection | DOAJ |
| description | Results of the study of the spontaneous apoptosis mechanisms of peripheral blood lymphocytes of ovary cancer (OC) patients are presented in the article. Dynamics of mitochondrial potential (MP) change, level of phosphatidylserine (PS) expression and DNA fragmentation were used as apoptosis markers. These parameters were estimated by flow cytometry. During the incubation process, DNA fragmentation in OC patient lymphocytes were more intensive and observed during earlier stages than those in donor lymphocytes. Also, reliable decrease of MP and increase of PS expression level were observed. The study results revealed increased reactivity of mitochondrial lymphocytes in OC patients and as a result, decreased resistance to spontaneous apoptosis processes. |
| first_indexed | 2024-04-10T01:13:08Z |
| format | Article |
| id | doaj.art-708b313b1a5d4845a31d8b1b4c38affd |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:13:08Z |
| publishDate | 2007-06-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-708b313b1a5d4845a31d8b1b4c38affd2023-03-13T09:58:07ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842007-06-016281010.20538/1682-0363-2007-2-8-101899Spontaneous apoptosis of lymphocytes of ovary cancer patientsI. I. Antoneyeva0S. V. Boichuk1Ульяновский государственный университет, г. УльяновскКазанский государственный медицинский университет, г. КазаньResults of the study of the spontaneous apoptosis mechanisms of peripheral blood lymphocytes of ovary cancer (OC) patients are presented in the article. Dynamics of mitochondrial potential (MP) change, level of phosphatidylserine (PS) expression and DNA fragmentation were used as apoptosis markers. These parameters were estimated by flow cytometry. During the incubation process, DNA fragmentation in OC patient lymphocytes were more intensive and observed during earlier stages than those in donor lymphocytes. Also, reliable decrease of MP and increase of PS expression level were observed. The study results revealed increased reactivity of mitochondrial lymphocytes in OC patients and as a result, decreased resistance to spontaneous apoptosis processes.https://bulletin.ssmu.ru/jour/article/view/3243рак яичниковлимфоцитыапоптоз |
| spellingShingle | I. I. Antoneyeva S. V. Boichuk Spontaneous apoptosis of lymphocytes of ovary cancer patients Бюллетень сибирской медицины рак яичников лимфоциты апоптоз |
| title | Spontaneous apoptosis of lymphocytes of ovary cancer patients |
| title_full | Spontaneous apoptosis of lymphocytes of ovary cancer patients |
| title_fullStr | Spontaneous apoptosis of lymphocytes of ovary cancer patients |
| title_full_unstemmed | Spontaneous apoptosis of lymphocytes of ovary cancer patients |
| title_short | Spontaneous apoptosis of lymphocytes of ovary cancer patients |
| title_sort | spontaneous apoptosis of lymphocytes of ovary cancer patients |
| topic | рак яичников лимфоциты апоптоз |
| url | https://bulletin.ssmu.ru/jour/article/view/3243 |
| work_keys_str_mv | AT iiantoneyeva spontaneousapoptosisoflymphocytesofovarycancerpatients AT svboichuk spontaneousapoptosisoflymphocytesofovarycancerpatients |