Centrally Administered Tryptophan Suppresses Food Intake in Free Fed Chicks through the Serotonergic System
The effects of intracerebroventricular injection of L-tryptophan on feeding behavior and the levels of brain neurotransmitters (amino acids or monoamines) were investigated in ad libitum chicks. The tryptophan treatment (3 or 6μmol) significantly inhibited food intake in chicks at 30min post...
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| Format: | Article |
| Language: | English |
| Published: |
Japan Poultry Science Association
2008-07-01
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| Series: | The Journal of Poultry Science |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jpsa/45/3/45_3_215/_pdf/-char/en |
| _version_ | 1827938129797971968 |
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| author | Takashi Bungo Kazuki Yahata Tomofumi Izumi Koh-Ichi Dodo Kouichi Yanagita Jun-ichi Shiraishi Yoshiyuki Ohta Masanori Fujita |
| author_facet | Takashi Bungo Kazuki Yahata Tomofumi Izumi Koh-Ichi Dodo Kouichi Yanagita Jun-ichi Shiraishi Yoshiyuki Ohta Masanori Fujita |
| author_sort | Takashi Bungo |
| collection | DOAJ |
| description | The effects of intracerebroventricular injection of L-tryptophan on feeding behavior and the levels of brain neurotransmitters (amino acids or monoamines) were investigated in ad libitum chicks. The tryptophan treatment (3 or 6μmol) significantly inhibited food intake in chicks at 30min postinjection. The levels of serotonin (5-HT) and its metabolite, 5-dihydroxyindolacetic acid, in chicks treated with tryptophan were significantly higher than those with saline at 15min postinjection. However, there were no differences in the levels of catecholamines (adrenaline, noradrenaline and dopamine) and amino acid neurotransmitters (e.g., γ-aminobutyric acid, glycine and glutamic acid). The tryptophan-induced anorexia tended to be attenuated by the 5-HT2A receptor antagonist ketanserin (10μg). These results suggest that the administration of tryptophan into the chick brain produces the anorexic effect, and that the change in brain 5-HT content may be involved in this anorexia. |
| first_indexed | 2024-03-13T08:34:59Z |
| format | Article |
| id | doaj.art-708c9404e7514395ab6cc50e55938da5 |
| institution | Directory Open Access Journal |
| issn | 1346-7395 1349-0486 |
| language | English |
| last_indexed | 2024-03-13T08:34:59Z |
| publishDate | 2008-07-01 |
| publisher | Japan Poultry Science Association |
| record_format | Article |
| series | The Journal of Poultry Science |
| spelling | doaj.art-708c9404e7514395ab6cc50e55938da52023-05-31T00:35:08ZengJapan Poultry Science AssociationThe Journal of Poultry Science1346-73951349-04862008-07-0145321521910.2141/jpsa.45.215jpsaCentrally Administered Tryptophan Suppresses Food Intake in Free Fed Chicks through the Serotonergic SystemTakashi Bungo0Kazuki Yahata1Tomofumi Izumi2Koh-Ichi Dodo3Kouichi Yanagita4Jun-ichi Shiraishi5Yoshiyuki Ohta6Masanori Fujita7Department of Bioresource Science, Graduate School of Biosphere Science, Hiroshima University, JapanDepartment of Agrobiological Science, Faculty of Agriculture, Ehime University, JapanDepartment of Agrobiological Science, Faculty of Agriculture, Ehime University, JapanDepartment of Agrobiological Science, Faculty of Agriculture, Ehime University, JapanDepartment of Bioresource Science, Graduate School of Biosphere Science, Hiroshima University, JapanDepartment of Bioresource Science, Graduate School of Biosphere Science, Hiroshima University, JapanDepartment of Animal Science, Nippon Veterinary and Life Science University, JapanDepartment of Bioresource Science, Graduate School of Biosphere Science, Hiroshima University, JapanThe effects of intracerebroventricular injection of L-tryptophan on feeding behavior and the levels of brain neurotransmitters (amino acids or monoamines) were investigated in ad libitum chicks. The tryptophan treatment (3 or 6μmol) significantly inhibited food intake in chicks at 30min postinjection. The levels of serotonin (5-HT) and its metabolite, 5-dihydroxyindolacetic acid, in chicks treated with tryptophan were significantly higher than those with saline at 15min postinjection. However, there were no differences in the levels of catecholamines (adrenaline, noradrenaline and dopamine) and amino acid neurotransmitters (e.g., γ-aminobutyric acid, glycine and glutamic acid). The tryptophan-induced anorexia tended to be attenuated by the 5-HT2A receptor antagonist ketanserin (10μg). These results suggest that the administration of tryptophan into the chick brain produces the anorexic effect, and that the change in brain 5-HT content may be involved in this anorexia.https://www.jstage.jst.go.jp/article/jpsa/45/3/45_3_215/_pdf/-char/encentral nervous systemchickfood intaketryptophanserotonin |
| spellingShingle | Takashi Bungo Kazuki Yahata Tomofumi Izumi Koh-Ichi Dodo Kouichi Yanagita Jun-ichi Shiraishi Yoshiyuki Ohta Masanori Fujita Centrally Administered Tryptophan Suppresses Food Intake in Free Fed Chicks through the Serotonergic System The Journal of Poultry Science central nervous system chick food intake tryptophan serotonin |
| title | Centrally Administered Tryptophan Suppresses Food Intake in Free Fed Chicks through the Serotonergic System |
| title_full | Centrally Administered Tryptophan Suppresses Food Intake in Free Fed Chicks through the Serotonergic System |
| title_fullStr | Centrally Administered Tryptophan Suppresses Food Intake in Free Fed Chicks through the Serotonergic System |
| title_full_unstemmed | Centrally Administered Tryptophan Suppresses Food Intake in Free Fed Chicks through the Serotonergic System |
| title_short | Centrally Administered Tryptophan Suppresses Food Intake in Free Fed Chicks through the Serotonergic System |
| title_sort | centrally administered tryptophan suppresses food intake in free fed chicks through the serotonergic system |
| topic | central nervous system chick food intake tryptophan serotonin |
| url | https://www.jstage.jst.go.jp/article/jpsa/45/3/45_3_215/_pdf/-char/en |
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