A Glimmer of Hope: Recent Updates and Future Challenges in Zika Vaccine Development
The emergence and rapid spread of Zika virus (ZIKV) on a global scale as well as the establishment of a causal link between Zika infection and congenital syndrome and neurological disorders triggered unprecedented efforts towards the development of a safe and effective Zika vaccine. Multiple vaccine...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/12/12/1371 |
| _version_ | 1827701045863645184 |
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| author | Priscila M. S. Castanha Ernesto T. A. Marques |
| author_facet | Priscila M. S. Castanha Ernesto T. A. Marques |
| author_sort | Priscila M. S. Castanha |
| collection | DOAJ |
| description | The emergence and rapid spread of Zika virus (ZIKV) on a global scale as well as the establishment of a causal link between Zika infection and congenital syndrome and neurological disorders triggered unprecedented efforts towards the development of a safe and effective Zika vaccine. Multiple vaccine platforms, including purified inactivated virus, nucleic acid vaccines, live-attenuated vaccines, and viral-vectored vaccines, have advanced to human clinical trials. In this review, we discuss the recent advances in the field of Zika vaccine development and the challenges for future clinical efficacy trials. We provide a brief overview on Zika vaccine platforms in the pipeline before summarizing the vaccine candidates in clinical trials, with a focus on recent, promising results from vaccine candidates that completed phase I trials. Despite low levels of transmission during recent years, ZIKV has become endemic in the Americas and the potential of large Zika outbreaks remains real. It is important for vaccine developers to continue developing their Zika vaccines, so that a potential vaccine is ready for deployment and clinical efficacy trials when the next ZIKV outbreak occurs. |
| first_indexed | 2024-03-10T14:26:14Z |
| format | Article |
| id | doaj.art-708d0caab31a4150b8240e018f99accc |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T14:26:14Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-708d0caab31a4150b8240e018f99accc2023-11-20T22:59:41ZengMDPI AGViruses1999-49152020-11-011212137110.3390/v12121371A Glimmer of Hope: Recent Updates and Future Challenges in Zika Vaccine DevelopmentPriscila M. S. Castanha0Ernesto T. A. Marques1Graduate School of Public Health, Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA 15261, USAGraduate School of Public Health, Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA 15261, USAThe emergence and rapid spread of Zika virus (ZIKV) on a global scale as well as the establishment of a causal link between Zika infection and congenital syndrome and neurological disorders triggered unprecedented efforts towards the development of a safe and effective Zika vaccine. Multiple vaccine platforms, including purified inactivated virus, nucleic acid vaccines, live-attenuated vaccines, and viral-vectored vaccines, have advanced to human clinical trials. In this review, we discuss the recent advances in the field of Zika vaccine development and the challenges for future clinical efficacy trials. We provide a brief overview on Zika vaccine platforms in the pipeline before summarizing the vaccine candidates in clinical trials, with a focus on recent, promising results from vaccine candidates that completed phase I trials. Despite low levels of transmission during recent years, ZIKV has become endemic in the Americas and the potential of large Zika outbreaks remains real. It is important for vaccine developers to continue developing their Zika vaccines, so that a potential vaccine is ready for deployment and clinical efficacy trials when the next ZIKV outbreak occurs.https://www.mdpi.com/1999-4915/12/12/1371Zika virusvaccine candidatesvaccine platformsclinical trials |
| spellingShingle | Priscila M. S. Castanha Ernesto T. A. Marques A Glimmer of Hope: Recent Updates and Future Challenges in Zika Vaccine Development Viruses Zika virus vaccine candidates vaccine platforms clinical trials |
| title | A Glimmer of Hope: Recent Updates and Future Challenges in Zika Vaccine Development |
| title_full | A Glimmer of Hope: Recent Updates and Future Challenges in Zika Vaccine Development |
| title_fullStr | A Glimmer of Hope: Recent Updates and Future Challenges in Zika Vaccine Development |
| title_full_unstemmed | A Glimmer of Hope: Recent Updates and Future Challenges in Zika Vaccine Development |
| title_short | A Glimmer of Hope: Recent Updates and Future Challenges in Zika Vaccine Development |
| title_sort | glimmer of hope recent updates and future challenges in zika vaccine development |
| topic | Zika virus vaccine candidates vaccine platforms clinical trials |
| url | https://www.mdpi.com/1999-4915/12/12/1371 |
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