| Summary: | Abstract The analysis of brain function in resting-state network (RSN) models, ascertained through the functional connectivity pattern of resting-state functional magnetic resonance imaging (rs-fMRI), is sufficiently powerful for studying large-scale functional integration of the brain. However, in RSN-based research, the network architecture has been regarded as the same through different frequency bands. Thus, here, we aimed to examined whether the network architecture changes with frequency. The blood oxygen level-dependent (BOLD) signal was decomposed into four frequency bands—ranging from 0.007 to 0.438 Hz—and the clustering algorithm was applied to each of them. The best clustering number was selected for each frequency band based on the overlap ratio with task activation maps. The results demonstrated that resting-state BOLD signals exhibited frequency-specific network architecture; that is, the networks finely subdivided in the lower frequency bands were integrated into fewer networks in higher frequency bands rather than reconfigured, and the default mode network and networks related to perception had sufficiently strong architecture to survive in an environment with a lower signal-to-noise ratio. These findings provide a novel framework to enable improved understanding of brain function through the multiband frequency analysis of ultra-slow rs-fMRI data.
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