<i>Mentha piperita</i>: Essential Oil and Extracts, Their Biological Activities, and Perspectives on the Development of New Medicinal and Cosmetic Products
This review aims to analyze <i>Mentha piperita</i> L. as a potential raw material for the development of new health-promoting products (nutraceuticals, cosmetics, and pharmaceutical products). A lot of scientific publications were retrieved from the Scopus, PubMed, and Google Scholar dat...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/21/7444 |
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| author | Nataliia Hudz Lesya Kobylinska Katarzyna Pokajewicz Vladimira Horčinová Sedláčková Roman Fedin Mariia Voloshyn Iryna Myskiv Ján Brindza Piotr Paweł Wieczorek Jacek Lipok |
| author_facet | Nataliia Hudz Lesya Kobylinska Katarzyna Pokajewicz Vladimira Horčinová Sedláčková Roman Fedin Mariia Voloshyn Iryna Myskiv Ján Brindza Piotr Paweł Wieczorek Jacek Lipok |
| author_sort | Nataliia Hudz |
| collection | DOAJ |
| description | This review aims to analyze <i>Mentha piperita</i> L. as a potential raw material for the development of new health-promoting products (nutraceuticals, cosmetics, and pharmaceutical products). A lot of scientific publications were retrieved from the Scopus, PubMed, and Google Scholar databases which enable the study and generalization of the extraction procedures, key biologically active compounds of essential oil and extracts, biological properties, and therapeutic potential of <i>M. piperita</i>, along with perspectives on the development of its dosage forms, including combinations of synthetic active substances and herbal preparations of <i>M. piperita</i>. The results of this review indicate that <i>M. piperita</i> is a source rich in phytoconstituents of different chemical nature and can be regarded as a source of active substances to enhance health and to develop medicinal products for complementary therapy of various conditions, especially those related with oxidant stress, inflammation, and moderate infections. Essential oil has a broad spectrum of activities. Depending on the test and concentration, this essential oil has both anti- and prooxidant properties. Gram-positive bacteria are more sensitive to the essential oil of <i>M. piperita</i> than Gram-negative ones. This review also considered some facets of the standardization of essential oil and extracts of <i>M. piperita</i>. Among the identified phenolics of extracts were caffeic acid, rosmarinic acid, eriocitrin, luteolin derivates (luteolin-7-<i>O</i>-rutinoside, luteolin-7-<i>O</i>-glucoronide), and hesperidin. The concentration of these phenolics depends on the solvent used. This review also considered the relationships between the chemical component and biological activity. The results showed that the essential oil and extracts reduced inflammation in vitro by inhibiting the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), and in vivo by reducing the paw edema induced using carrageenan injection in rats. Therefore, herbal preparations of <i>M. piperita</i> are promising medicinal and cosmetic preparations for their usage in skincare and oral cavity care products with antimicrobial, anti-inflammatory, and wound-healing properties. This plant can also be regarded as a platform for the development of antibacterial preparations and combined anti-inflammatory and cardioprotective medicinal products (synthetic active substances plus herbal preparations). This review could be considered for the justification of the composition of some medicinal products during their pharmaceutical development for writing a registration dossier in the format of Common Technical Document. |
| first_indexed | 2024-03-11T11:24:21Z |
| format | Article |
| id | doaj.art-708e93423bb449c0a07bf8fb8fee9a07 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T11:24:21Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-708e93423bb449c0a07bf8fb8fee9a072023-11-10T15:09:01ZengMDPI AGMolecules1420-30492023-11-012821744410.3390/molecules28217444<i>Mentha piperita</i>: Essential Oil and Extracts, Their Biological Activities, and Perspectives on the Development of New Medicinal and Cosmetic ProductsNataliia Hudz0Lesya Kobylinska1Katarzyna Pokajewicz2Vladimira Horčinová Sedláčková3Roman Fedin4Mariia Voloshyn5Iryna Myskiv6Ján Brindza7Piotr Paweł Wieczorek8Jacek Lipok9Department of Pharmacy and Ecological Chemistry, University of Opole, 45-052 Opole, PolandDepartment of Biochemistry, Danylo Halytsky Lviv National Medical University, 79010 Lviv, UkraineDepartment of Analytical Chemistry, University of Opole, 45-052 Opole, PolandFaculty of Agrobiology and Food Resources, Slovak University of Agriculture in Nitra, 94976 Nitra, SlovakiaDepartment of Pharmacy and Biology, Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies of Lviv, 79010 Lviv, UkraineDepartment of Foreign Languages, Lviv Polytechnic National University, 79000 Lviv, UkraineDepartment of Foreign Languages, Lviv Polytechnic National University, 79000 Lviv, UkraineFaculty of Agrobiology and Food Resources, Slovak University of Agriculture in Nitra, 94976 Nitra, SlovakiaDepartment of Analytical Chemistry, University of Opole, 45-052 Opole, PolandDepartment of Pharmacy and Ecological Chemistry, University of Opole, 45-052 Opole, PolandThis review aims to analyze <i>Mentha piperita</i> L. as a potential raw material for the development of new health-promoting products (nutraceuticals, cosmetics, and pharmaceutical products). A lot of scientific publications were retrieved from the Scopus, PubMed, and Google Scholar databases which enable the study and generalization of the extraction procedures, key biologically active compounds of essential oil and extracts, biological properties, and therapeutic potential of <i>M. piperita</i>, along with perspectives on the development of its dosage forms, including combinations of synthetic active substances and herbal preparations of <i>M. piperita</i>. The results of this review indicate that <i>M. piperita</i> is a source rich in phytoconstituents of different chemical nature and can be regarded as a source of active substances to enhance health and to develop medicinal products for complementary therapy of various conditions, especially those related with oxidant stress, inflammation, and moderate infections. Essential oil has a broad spectrum of activities. Depending on the test and concentration, this essential oil has both anti- and prooxidant properties. Gram-positive bacteria are more sensitive to the essential oil of <i>M. piperita</i> than Gram-negative ones. This review also considered some facets of the standardization of essential oil and extracts of <i>M. piperita</i>. Among the identified phenolics of extracts were caffeic acid, rosmarinic acid, eriocitrin, luteolin derivates (luteolin-7-<i>O</i>-rutinoside, luteolin-7-<i>O</i>-glucoronide), and hesperidin. The concentration of these phenolics depends on the solvent used. This review also considered the relationships between the chemical component and biological activity. The results showed that the essential oil and extracts reduced inflammation in vitro by inhibiting the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), and in vivo by reducing the paw edema induced using carrageenan injection in rats. Therefore, herbal preparations of <i>M. piperita</i> are promising medicinal and cosmetic preparations for their usage in skincare and oral cavity care products with antimicrobial, anti-inflammatory, and wound-healing properties. This plant can also be regarded as a platform for the development of antibacterial preparations and combined anti-inflammatory and cardioprotective medicinal products (synthetic active substances plus herbal preparations). This review could be considered for the justification of the composition of some medicinal products during their pharmaceutical development for writing a registration dossier in the format of Common Technical Document.https://www.mdpi.com/1420-3049/28/21/7444<i>M. piperita</i>essential oilextractsantimicrobial activityantioxidant potentialanti-inflammatory activity |
| spellingShingle | Nataliia Hudz Lesya Kobylinska Katarzyna Pokajewicz Vladimira Horčinová Sedláčková Roman Fedin Mariia Voloshyn Iryna Myskiv Ján Brindza Piotr Paweł Wieczorek Jacek Lipok <i>Mentha piperita</i>: Essential Oil and Extracts, Their Biological Activities, and Perspectives on the Development of New Medicinal and Cosmetic Products Molecules <i>M. piperita</i> essential oil extracts antimicrobial activity antioxidant potential anti-inflammatory activity |
| title | <i>Mentha piperita</i>: Essential Oil and Extracts, Their Biological Activities, and Perspectives on the Development of New Medicinal and Cosmetic Products |
| title_full | <i>Mentha piperita</i>: Essential Oil and Extracts, Their Biological Activities, and Perspectives on the Development of New Medicinal and Cosmetic Products |
| title_fullStr | <i>Mentha piperita</i>: Essential Oil and Extracts, Their Biological Activities, and Perspectives on the Development of New Medicinal and Cosmetic Products |
| title_full_unstemmed | <i>Mentha piperita</i>: Essential Oil and Extracts, Their Biological Activities, and Perspectives on the Development of New Medicinal and Cosmetic Products |
| title_short | <i>Mentha piperita</i>: Essential Oil and Extracts, Their Biological Activities, and Perspectives on the Development of New Medicinal and Cosmetic Products |
| title_sort | i mentha piperita i essential oil and extracts their biological activities and perspectives on the development of new medicinal and cosmetic products |
| topic | <i>M. piperita</i> essential oil extracts antimicrobial activity antioxidant potential anti-inflammatory activity |
| url | https://www.mdpi.com/1420-3049/28/21/7444 |
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