The efficacy and safety of dexmedetomidine in cardiac surgery patients: A systematic review and meta-analysis.
This study aimed to evaluate the efficacy and safety of dexmedetomidine versus any other treatment without dexmedetomidine in patients who have undergone cardiac surgery. Electronic databases including PubMed, Embase, and Cochrane Library were systematically searched without limitations of language...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6145508?pdf=render |
| _version_ | 1819047073812578304 |
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| author | Guobin Wang Jianhua Niu Zhitao Li Haifeng Lv Hongliu Cai |
| author_facet | Guobin Wang Jianhua Niu Zhitao Li Haifeng Lv Hongliu Cai |
| author_sort | Guobin Wang |
| collection | DOAJ |
| description | This study aimed to evaluate the efficacy and safety of dexmedetomidine versus any other treatment without dexmedetomidine in patients who have undergone cardiac surgery. Electronic databases including PubMed, Embase, and Cochrane Library were systematically searched without limitations of language and publication time. Randomized controlled trials (RCTs) aiming to evaluate the efficacy and safety of dexmedetomidine versus any other treatment without dexmedetomidine in patients that have undergone cardiac surgery were selected. Endpoints such as hemodynamic indexes and adverse events in eligible studies were extracted by two researchers, independently. The data was analyzed using RevMan 5.3 and Stata 11.0 software. A total of 18 RCTs met the inclusion criteria, involving 1730 patients. Compared to control (any treatment without dexmedetomidine), dexmedetomidine showed a pooled mean difference (MD) of -14.46 [95% confidence interval(CI): -24.69, -4.23; p<0.01] for systolic arterial pressure, a standardized mean difference (SMD) of -1.74 for mean arterial blood pressure (95% CI: -2.80, -0.68; P < 0.01), -2.12 (95%CI: -3.23, -1.00; p<0.01) for heart rate, and combined odds ratio (OR) of 0.22 (95%CI: 0.11, 0.44; p<0.01) for tachycardia, 3.44 (95%CI: 1.95, 5.96; p<0.01) for bradycardia, 0.74 (95%CI: 0.49, 1.12; p>0.05) for atrial fibrillation, and 0.99 (95%CI: 0.51, 1.90; p>0.05) for hypotension. In addition, dexmedetomidine could reduce time of surgery and stay in intensive care units, improve delirium with good safety. Our study shows clinical application of dexmedetomidine in cardiac surgery patients can reduce risks of abnormal hemodynamics with good safety. |
| first_indexed | 2024-12-21T10:54:34Z |
| format | Article |
| id | doaj.art-708eccec804f4aedbeb1e80bf64884f7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T10:54:34Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-708eccec804f4aedbeb1e80bf64884f72022-12-21T19:06:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01139e020262010.1371/journal.pone.0202620The efficacy and safety of dexmedetomidine in cardiac surgery patients: A systematic review and meta-analysis.Guobin WangJianhua NiuZhitao LiHaifeng LvHongliu CaiThis study aimed to evaluate the efficacy and safety of dexmedetomidine versus any other treatment without dexmedetomidine in patients who have undergone cardiac surgery. Electronic databases including PubMed, Embase, and Cochrane Library were systematically searched without limitations of language and publication time. Randomized controlled trials (RCTs) aiming to evaluate the efficacy and safety of dexmedetomidine versus any other treatment without dexmedetomidine in patients that have undergone cardiac surgery were selected. Endpoints such as hemodynamic indexes and adverse events in eligible studies were extracted by two researchers, independently. The data was analyzed using RevMan 5.3 and Stata 11.0 software. A total of 18 RCTs met the inclusion criteria, involving 1730 patients. Compared to control (any treatment without dexmedetomidine), dexmedetomidine showed a pooled mean difference (MD) of -14.46 [95% confidence interval(CI): -24.69, -4.23; p<0.01] for systolic arterial pressure, a standardized mean difference (SMD) of -1.74 for mean arterial blood pressure (95% CI: -2.80, -0.68; P < 0.01), -2.12 (95%CI: -3.23, -1.00; p<0.01) for heart rate, and combined odds ratio (OR) of 0.22 (95%CI: 0.11, 0.44; p<0.01) for tachycardia, 3.44 (95%CI: 1.95, 5.96; p<0.01) for bradycardia, 0.74 (95%CI: 0.49, 1.12; p>0.05) for atrial fibrillation, and 0.99 (95%CI: 0.51, 1.90; p>0.05) for hypotension. In addition, dexmedetomidine could reduce time of surgery and stay in intensive care units, improve delirium with good safety. Our study shows clinical application of dexmedetomidine in cardiac surgery patients can reduce risks of abnormal hemodynamics with good safety.http://europepmc.org/articles/PMC6145508?pdf=render |
| spellingShingle | Guobin Wang Jianhua Niu Zhitao Li Haifeng Lv Hongliu Cai The efficacy and safety of dexmedetomidine in cardiac surgery patients: A systematic review and meta-analysis. PLoS ONE |
| title | The efficacy and safety of dexmedetomidine in cardiac surgery patients: A systematic review and meta-analysis. |
| title_full | The efficacy and safety of dexmedetomidine in cardiac surgery patients: A systematic review and meta-analysis. |
| title_fullStr | The efficacy and safety of dexmedetomidine in cardiac surgery patients: A systematic review and meta-analysis. |
| title_full_unstemmed | The efficacy and safety of dexmedetomidine in cardiac surgery patients: A systematic review and meta-analysis. |
| title_short | The efficacy and safety of dexmedetomidine in cardiac surgery patients: A systematic review and meta-analysis. |
| title_sort | efficacy and safety of dexmedetomidine in cardiac surgery patients a systematic review and meta analysis |
| url | http://europepmc.org/articles/PMC6145508?pdf=render |
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